about
p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcriptionRedox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degronHDAC inhibitors increase NRF2-signaling in tumour cells and blunt the efficacy of co-adminstered cytotoxic agentsKeap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expressionKeap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals.Utility of siRNA against Keap1 as a strategy to stimulate a cancer chemopreventive phenotype.Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome.Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity.Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1-NRF2 pathway, and not the BACH1-NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compNRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer.Olaparib, Monotherapy or with Ionizing Radiation, Exacerbates DNA Damage in Normal Tissues: Insights from a New p21 Reporter Mouse.Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway.SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner.Targeting the Ataxia Telangiectasia Mutated-null phenotype in chronic lymphocytic leukemia with pro-oxidants.Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence.Activation of hepatic Nrf2 in vivo by acetaminophen in CD-1 mice.1-Cyano-2,3-epithiopropane is a novel plant-derived chemopreventive agent which induces cytoprotective genes that afford resistance against the genotoxic alpha,beta-unsaturated aldehyde acrolein.Cross-talk between transcription factors AhR and Nrf2: lessons for cancer chemoprevention from dioxin.Measuring in vivo responses to endogenous and exogenous oxidative stress using a novel haem oxygenase 1 reporter mouse.The double-edged sword of Nrf2: subversion of redox homeostasis during the evolution of cancer.Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: a two-site interaction model for the Nrf2-Keap1 complex.
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Q24310885-E0C8FBCA-92A1-464B-9A5F-74E4AC5F5219Q28261724-2ACDD1C4-52F2-4929-B63D-58BD6E76184FQ28545231-72B2BC08-FC21-4EBD-9905-0CACA124B761Q29615644-C419BF28-628D-4869-BB8E-3C2C911CBB92Q30497261-603304FA-C769-4065-9224-4218B82A9DBCQ33780763-C94CE0BD-B3E4-41D9-A787-C733BF688BB1Q35974394-DE947E76-A7AF-495D-B1F2-8F1135527A75Q36467640-9A437460-D7B7-4BB1-9251-5209370989A2Q36851342-BE732940-EB31-4DF4-8B40-5537C9C33BA7Q37423465-C685E0E8-9171-47AC-8A45-47AAE347D965Q37471094-D54FF5E8-17C6-42FC-B872-E419E4A80980Q37743477-F1D1D7BE-3F36-474E-873A-658837A07EDBQ39606140-21FE9A48-1EAF-431F-B7BD-DD884C22D55CQ40972934-94FE6F5C-D42A-4D52-BA26-BB4DDDD8D47AQ42157111-BC6FFFC9-AC51-44E2-882D-86DB5417C31DQ44880248-D6F4049E-EBFE-4937-83C3-645EEAC325E8Q45919580-5F1909C2-3A63-4C76-8088-3F5DE5B76679Q45921478-1F7BD899-A598-4FEF-8CD4-9EFAFB5D3683Q47111246-4418FFC2-7092-4397-AB6B-780BB6D59A8AQ53348313-F36B3F1D-56B3-463D-B168-4041E177864CQ53616483-94F9E09E-28FE-4625-80D9-4D351AA63D40
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description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Michael McMahon
@ast
Michael McMahon
@en
Michael McMahon
@es
Michael McMahon
@nl
Michael McMahon
@sl
type
label
Michael McMahon
@ast
Michael McMahon
@en
Michael McMahon
@es
Michael McMahon
@nl
Michael McMahon
@sl
prefLabel
Michael McMahon
@ast
Michael McMahon
@en
Michael McMahon
@es
Michael McMahon
@nl
Michael McMahon
@sl
P106
P21
P2798
P31
P496
0000-0001-8615-9351