Transgenic mice expressing human immunodeficiency virus type 1 in immune cells develop a severe AIDS-like disease
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Human immunodeficiency virus type 1 Nef mediates sustained membrane expression of tumor necrosis factor and the related cytokine LIGHT on activated T cells.IKK2 inhibitor alleviates kidney and wasting diseases in a murine model of human AIDSViral Subversion Mechanisms in Chronic Kidney Disease PathogenesisHIV-1 Nef interaction influences the ATP-binding site of the Src-family kinase, HckThe pathogenicity of human immunodeficiency virus (HIV) type 1 Nef in CD4C/HIV transgenic mice is abolished by mutation of its SH3-binding domain, and disease development is delayed in the absence of Hck.Nef does not contribute to replication differences between R5 pre-AIDS and AIDS HIV-1 clones from patient ACH142Small molecule inhibition of HIV-1-induced MHC-I down-regulation identifies a temporally regulated switch in Nef actionHuman immunodeficiency virus-1 Nef expression induces intracellular accumulation of multivesicular bodies and major histocompatibility complex class II complexes: potential role of phosphatidylinositol 3-kinaseThe Nef-mediated AIDS-like disease of CD4C/human immunodeficiency virus transgenic mice is associated with increased Fas/FasL expression on T cells and T-cell death but is not prevented in Fas-, FasL-, tumor necrosis factor receptor 1-, or interleukNeutron reflectometry study of the conformation of HIV Nef bound to lipid membranesHIV-1/mycobacterium tuberculosis coinfection immunology: how does HIV-1 exacerbate tuberculosis?Expression of simian immunodeficiency virus nef in immune cells of transgenic mice leads to a severe AIDS-like disease.CD4-specific transgenic expression of human cyclin T1 markedly increases human immunodeficiency virus type 1 (HIV-1) production by CD4+ T lymphocytes and myeloid cells in mice transgenic for a provirus encoding a monocyte-tropic HIV-1 isolate.Cardiomyocytes undergo apoptosis in human immunodeficiency virus cardiomyopathy through mitochondrion- and death receptor-controlled pathwaysTrans-cellular introduction of HIV-1 protein Nef induces pathogenic response in Caenorhabditis elegans.CD8+ T cells but not polymorphonuclear leukocytes are required to limit chronic oral carriage of Candida albicans in transgenic mice expressing human immunodeficiency virus type 1.Discovery of a diaminoquinoxaline benzenesulfonamide antagonist of HIV-1 Nef function using a yeast-based phenotypic screenPronounced acute immunosuppression in vivo mediated by HIV Tat challengeHIV-1 Myristoylated Nef Treatment of Murine Microglial Cells Activates Inducible Nitric Oxide Synthase, NO2 Production and Neurotoxic Activity.High expression levels of BLyS/BAFF by blood dendritic cells and granulocytes are associated with B-cell dysregulation in SIV-infected rhesus macaques.Cardiac disease in transgenic mice expressing human immunodeficiency virus-1 nef in cells of the immune system.Influence of dendritic cells on B-cell responses during HIV infection.Immunopathogenesis of oropharyngeal candidiasis in human immunodeficiency virus infection.Fluctuations in Blood Marginal Zone B-Cell Frequencies May Reflect Migratory Patterns Associated with HIV-1 Disease Progression Status.Compartmentalization of the gut viral reservoir in HIV-1 infected patients.Genetic knockouts suggest a critical role for HIV co-receptors in models of HIV gp120-induced brain injuryHIV-1 Nef is associated with complex pulmonary vascular lesions in SHIV-nef-infected macaques.Mechanisms of HIV-1 Nef function and intracellular signaling.Macrophage-mediated responses to Candida albicans in mice expressing the human immunodeficiency virus type 1 transgene.B cell lymphoma in HIV transgenic mice.Adult AIDS-like disease in a novel inducible human immunodeficiency virus type 1 Nef transgenic mouse model: CD4+ T-cell activation is Nef dependent and can occur in the absence of lymphophenia.Controversies in the pathogenesis of HIV-associated renal diseases.The AIDS-like disease of CD4C/human immunodeficiency virus transgenic mice is associated with accumulation of immature CD11bHi dendritic cells.Characterization of Nef-CXCR4 interactions important for apoptosis induction.Primary human immunodeficiency virus type 1 nef alleles show major differences in pathogenicity in transgenic mice.Extracellular Nef protein targets CD4+ T cells for apoptosis by interacting with CXCR4 surface receptorsCD4+ T cells from CD4C/HIVNef transgenic mice show enhanced activation in vivo with impaired proliferation in vitro but are dispensable for the development of a severe AIDS-like organ diseaseSelective expression of human immunodeficiency virus Nef in specific immune cell populations of transgenic mice is associated with distinct AIDS-like phenotypes.Lymphocytic interstitial pneumonitis in HIV infected adults.Persistent NF-kappaB activation in renal epithelial cells in a mouse model of HIV-associated nephropathy.
P2860
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P2860
Transgenic mice expressing human immunodeficiency virus type 1 in immune cells develop a severe AIDS-like disease
description
1998 nî lūn-bûn
@nan
1998 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Transgenic mice expressing hum ...... lop a severe AIDS-like disease
@ast
Transgenic mice expressing hum ...... lop a severe AIDS-like disease
@en
type
label
Transgenic mice expressing hum ...... lop a severe AIDS-like disease
@ast
Transgenic mice expressing hum ...... lop a severe AIDS-like disease
@en
prefLabel
Transgenic mice expressing hum ...... lop a severe AIDS-like disease
@ast
Transgenic mice expressing hum ...... lop a severe AIDS-like disease
@en
P2093
P2860
P1433
P1476
Transgenic mice expressing hum ...... lop a severe AIDS-like disease
@en
P2093
P2860
P304
P577
1998-01-01T00:00:00Z