Metabotropic glutamate receptor 5 activity in the nucleus accumbens is required for the maintenance of ethanol self-administration in a rat genetic model of high alcohol intake
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Chronic alcohol neuroadaptation and stress contribute to susceptibility for alcohol craving and relapseGlutamatergic targets for new alcohol medicationsA Genetic Animal Model of Alcoholism for Screening Medications to Treat Addiction.Glutamatergic transmission in drug reward: implications for drug addictionInteractive Effects of Ethanol and HIV-1 Proteins on Novelty-Seeking Behaviors and Addiction-Related Gene ExpressionEthanol-Associated Changes in Glutamate Reward Neurocircuitry: A Minireview of Clinical and Preclinical Genetic Findings.Animal models for medications development targeting alcohol abuse using selectively bred rat lines: neurobiological and pharmacological validityEffects of the mGlu2/3 agonist LY379268 and the mGlu5 antagonist MTEP on ethanol seeking and reinforcement are differentially altered in rats with a history of ethanol dependenceRole of glutamate transporter 1 in the attenuation of alcohol intake.Adrenal steroid hormones and ethanol self-administration in male rhesus macaques.Stress hormone exposure reduces mGluR5 expression in the nucleus accumbens: functional implications for interoceptive sensitivity to alcohol.Effects of ceftriaxone on ethanol intake: a possible role for xCT and GLT-1 isoforms modulation of glutamate levels in P rats.Blockade of mGluR5 in the nucleus accumbens shell but not core attenuates heroin seeking behavior in rats.Ceftriaxone, a beta-lactam antibiotic, reduces ethanol consumption in alcohol-preferring rats.Activation of group II metabotropic glutamate receptors inhibits the discriminative stimulus effects of alcohol via selective activity within the amygdala.Metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP) microinfusions into the nucleus accumbens shell or ventral tegmental area attenuate the reinforcing effects of nicotine in ratsModerate Alcohol Drinking and the Amygdala Proteome: Identification and Validation of Calcium/Calmodulin Dependent Kinase II and AMPA Receptor Activity as Novel Molecular Mechanisms of the Positive Reinforcing Effects of Alcohol.Enhanced sensitivity to attenuation of conditioned reinstatement by the mGluR 2/3 agonist LY379268 and increased functional activity of mGluR 2/3 in rats with a history of ethanol dependenceDifferential Modulation of Thresholds for Intracranial Self-Stimulation by mGlu5 Positive and Negative Allosteric Modulators: Implications for Effects on Drug Self-Administration.The role of varenicline on alcohol-primed self-administration and seeking behavior in ratsFrequency of alcohol consumption in humans; the role of metabotropic glutamate receptors and downstream signaling pathwaysOperant ethanol self-administration increases extracellular-signal regulated protein kinase (ERK) phosphorylation in reward-related brain regions: selective regulation of positive reinforcement in the prefrontal cortex of C57BL/6J mice.mGlu receptors and drug addiction.mGluR7 genetics and alcohol: intersection yields clues for addiction.Rodent models and mechanisms of voluntary binge-like ethanol consumption: Examples, opportunities, and strategies for preclinical research.Role of the serotonergic system in alcohol dependence: from animal models to clinics.Enhanced AMPA receptor activity increases operant alcohol self-administration and cue-induced reinstatementThe endocannabinoid 2-arachidonoylglycerol mediates D1 and D2 receptor cooperative enhancement of rat nucleus accumbens core neuron firing.Effects of cefazolin and cefoperazone on glutamate transporter 1 isoforms and cystine/glutamate exchanger as well as alcohol drinking behavior in male alcohol-preferring rats.Effects of exposure to moderate levels of ethanol during prenatal brain development on dendritic length, branching, and spine density in the nucleus accumbens and dorsal striatum of adult ratsFunctional regulation of PI3K-associated signaling in the accumbens by binge alcohol drinking in male but not female mice.Craving in alcohol-dependent patients after detoxification is related to glutamatergic dysfunction in the nucleus accumbens and the anterior cingulate cortex.Sex and the Lab: An Alcohol-Focused Commentary on the NIH Initiative to Balance Sex in Cell and Animal Studies.Transient increase in alcohol self-administration following a period of chronic exposure to corticosterone.Disruption of alcohol-related memories by mTORC1 inhibition prevents relapse.The Nucleus Accumbens: Mechanisms of Addiction across Drug Classes Reflect the Importance of Glutamate HomeostasisThe Effect of mGluR5 Antagonism During Binge Drinkingon Subsequent Ethanol Intake in C57BL/6J Mice: Sex- and Age-Induced DifferencesAdolescent Mice Are Resilient to Alcohol Withdrawal-Induced Anxiety and Changes in Indices of Glutamate Function within the Nucleus Accumbens.Neurobiology of consummatory behavior: mechanisms underlying overeating and drug use.Overexpression of the steroidogenic enzyme cytochrome P450 side chain cleavage in the ventral tegmental area increases 3α,5α-THP and reduces long-term operant ethanol self-administration.
P2860
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P2860
Metabotropic glutamate receptor 5 activity in the nucleus accumbens is required for the maintenance of ethanol self-administration in a rat genetic model of high alcohol intake
description
2009 nî lūn-bûn
@nan
2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Metabotropic glutamate recepto ...... c model of high alcohol intake
@ast
Metabotropic glutamate recepto ...... c model of high alcohol intake
@en
type
label
Metabotropic glutamate recepto ...... c model of high alcohol intake
@ast
Metabotropic glutamate recepto ...... c model of high alcohol intake
@en
prefLabel
Metabotropic glutamate recepto ...... c model of high alcohol intake
@ast
Metabotropic glutamate recepto ...... c model of high alcohol intake
@en
P2093
P2860
P1476
Metabotropic glutamate recepto ...... c model of high alcohol intake
@en
P2093
Amanda C Sharko
Joyce Besheer
Julie J M Grondin
Reginald Cannady
Sara Faccidomo
P2860
P304
P356
10.1016/J.BIOPSYCH.2009.09.016
P407
P577
2009-11-07T00:00:00Z