The mGluR5 antagonist MPEP selectively inhibits the onset and maintenance of ethanol self-administration in C57BL/6J mice. - Wikidata - wikimedia - TriplyDB

The mGluR5 antagonist MPEP selectively inhibits the onset and maintenance of ethanol self-administration in C57BL/6J mice.

The mGluR5 antagonist MPEP selectively inhibits the onset and maintenance of ethanol self-administration in C57BL/6J mice.

http://www.wikidata.org/entity/Q33788860

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Neuropharmacology of alcohol addiction Glutamatergic substrates of drug addiction and alcoholism mGluR5 antagonism attenuates methamphetamine reinforcement and prevents reinstatement of methamphetamine-seeking behavior in rats Negative Allosteric Modulators of Metabotropic Glutamate Receptors Subtype 5 in Addiction: a Therapeutic Window Glutamatergic targets for new alcohol medications Glutamatergic transmission in drug reward: implications for drug addiction Differential effects of chronic ethanol consumption and withdrawal on homer/glutamate receptor expression in subregions of the accumbens and amygdala of P rats Ethanol-Associated Changes in Glutamate Reward Neurocircuitry: A Minireview of Clinical and Preclinical Genetic Findings.Nucleotide sequence variation within the PI3K p85 alpha gene associates with alcohol risk drinking behaviour in adolescents Operant ethanol self-administration in ethanol dependent mice.Cue-conditioned alcohol seeking in rats following abstinence: involvement of metabotropic glutamate 5 receptors.Interoceptive effects of alcohol require mGlu5 receptor activity in the nucleus accumbens Metabotropic glutamate receptor 5 activity in the nucleus accumbens is required for the maintenance of ethanol self-administration in a rat genetic model of high alcohol intake Effects of the mGlu2/3 agonist LY379268 and the mGlu5 antagonist MTEP on ethanol seeking and reinforcement are differentially altered in rats with a history of ethanol dependence Role of glutamate transporter 1 in the attenuation of alcohol intake.Cognitive effects of Group I metabotropic glutamate receptor ligands in the context of drug addiction.How adaptation of the brain to alcohol leads to dependence: a pharmacological perspective.The metabotropic glutamate receptor subtype 5 mediates sensitivity to the sedative properties of ethanol.Assessment of GABA-B, metabotropic glutamate, and opioid receptor involvement in an animal model of binge drinking Metabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP.Implication of the purinergic system in alcohol use disorders.Ceftriaxone, a beta-lactam antibiotic, reduces ethanol consumption in alcohol-preferring rats.mGlu5 receptors are involved in the discriminative stimulus effects of self-administered ethanol in rats Effects of mGluR1 antagonism in the dorsal hippocampus on drug context-induced reinstatement of cocaine-seeking behavior in rats.Metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP) microinfusions into the nucleus accumbens shell or ventral tegmental area attenuate the reinforcing effects of nicotine in rats Frequency of alcohol consumption in humans; the role of metabotropic glutamate receptors and downstream signaling pathways mGlu receptors and drug addiction.Nucleus accumbens mGluR5-associated signaling regulates binge alcohol drinking under drinking-in-the-dark procedures.Group 1 mGlu-family proteins promote neuroadaptation to ethanol and withdrawal-associated hippocampal damage.Rodent models and mechanisms of voluntary binge-like ethanol consumption: Examples, opportunities, and strategies for preclinical research.Effects of mGlu1-receptor blockade on ethanol self-administration in inbred alcohol-preferring rats.Regulation of motivation to self-administer ethanol by mGluR5 in alcohol-preferring (P) rats.Differential modulation of ethanol-induced sedation and hypnosis by metabotropic glutamate receptor antagonists in C57BL/6J mice.Nonselective suppression of operant ethanol and sucrose self-administration by the mGluR7 positive allosteric modulator AMN082.Metabotropic glutamate receptor 5 (mGluR5) regulation of ethanol sedation, dependence and consumption: relationship to acamprosate actions Cue-induced reinstatement of alcohol-seeking behavior is associated with increased ERK1/2 phosphorylation in specific limbic brain regions: blockade by the mGluR5 antagonist MPEP Neuroscience of alcoholism: molecular and cellular mechanisms Effects of topiramate and other anti-glutamatergic drugs on the acute intoxicating actions of ethanol in mice: modulation by genetic strain and stress.Metabotropic glutamate receptor ligands as potential therapeutics for addiction The Effect of mGluR5 Antagonism During Binge Drinkingon Subsequent Ethanol Intake in C57BL/6J Mice: Sex- and Age-Induced Differences

P2860

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P2860

The mGluR5 antagonist MPEP selectively inhibits the onset and maintenance of ethanol self-administration in C57BL/6J mice.

http://www.wikidata.org/entity/Q33788860

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2005 nî lūn-bûn

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2005 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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The mGluR5 antagonist MPEP sel ...... ministration in C57BL/6J mice.

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P2860

Selective mGluR5 antagonists MPEP and SIB-1893 decrease NMDA or glutamate-mediated neuronal toxicity through actions that reflect NMDA receptor antagonism

Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice

mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination

Distribution of metabotropic glutamate receptor mGluR3 in the mouse CNS: differential location relative to pre- and postsynaptic sites

The metabotropic glutamate receptors: structure and functions

Ionotropic glutamate receptors as sites of action for ethanol in the brain.

Acute effects of ethanol on GABAA and glycine receptor function.

Group I metabotropic glutamate receptors: implications for brain diseases.

A review of the effects of prenatal or early postnatal ethanol exposure on brain ligand-gated ion channels.

Pharmacological and anatomical evidence for an interaction between mGluR5- and GABA(A) alpha1-containing receptors in the discriminative stimulus effects of ethanol.

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