Effector CD4 cells are tolerized upon exposure to parenchymal self-antigen.
about
The activation and inactivation of mature CD4 T cells: a case for peripheral self-nonself discriminationTolerance induction in memory CD4 T cells requires two rounds of antigen-specific activation.In vivo cyclophosphamide and IL-2 treatment impedes self-antigen-induced effector CD4 cell tolerization: implications for adoptive immunotherapy.Effector CD4 cell tolerization is mediated through functional inactivation and involves preferential impairment of TNF-alpha and IFN-gamma expression potentials.Steady state dendritic cells present parenchymal self-antigen and contribute to, but are not essential for, tolerization of naive and Th1 effector CD4 cells.Dendritic cells program non-immunogenic prostate-specific T cell responses beginning at early stages of prostate tumorigenesis.Androgen ablation mitigates tolerance to a prostate/prostate cancer-restricted antigen.T-bet down-modulation in tolerized Th1 effector CD4 cells confers a TCR-distal signaling defect that selectively impairs IFN-gamma expression.Glycoprotein 96 can chaperone both MHC class I- and class II-restricted epitopes for in vivo presentation, but selectively primes CD8+ T cell effector function.Histone acetylation at the Ifng promoter in tolerized CD4 cells is associated with increased IFN-gamma expression during subsequent immunization to the same antigenPeripheral Tolerization of Effector and Memory T Cells: Implications for Autoimmunity and Tumor-Immunity.The E3 ubiquitin ligase Cbl-b regulates expansion but not functional activity of self-reactive CD4 T cellsAdoptive transfer of syngeneic T cells transduced with a chimeric antigen receptor that recognizes murine CD19 can eradicate lymphoma and normal B cells.Reciprocal changes in tumor antigenicity and antigen-specific T cell function during tumor progressionImmunization with mannosylated peptide induces poor T cell effector functions despite enhanced antigen presentation.Steady-state antigen-expressing dendritic cells terminate CD4+ memory T-cell responses.Tolerization of an established alphaB-crystallin-reactive T-cell response by intravenous antigen.
P2860
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P2860
Effector CD4 cells are tolerized upon exposure to parenchymal self-antigen.
description
2002 nî lūn-bûn
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2002 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Effector CD4 cells are tolerized upon exposure to parenchymal self-antigen.
@ast
Effector CD4 cells are tolerized upon exposure to parenchymal self-antigen.
@en
type
label
Effector CD4 cells are tolerized upon exposure to parenchymal self-antigen.
@ast
Effector CD4 cells are tolerized upon exposure to parenchymal self-antigen.
@en
prefLabel
Effector CD4 cells are tolerized upon exposure to parenchymal self-antigen.
@ast
Effector CD4 cells are tolerized upon exposure to parenchymal self-antigen.
@en
P2093
P2860
P1476
Effector CD4 cells are tolerized upon exposure to parenchymal self-antigen.
@en
P2093
Adam J Adler
Amy D Higgins
Marianne A Mihalyo
P2860
P304
P356
10.4049/JIMMUNOL.169.7.3622
P407
P577
2002-10-01T00:00:00Z