Maintenance of genomic integrity by p53: complementary roles for activated and non-activated p53.
about
Structure and expression of the TREX1 and TREX2 3' --> 5' exonuclease genesExcision of 3' termini by the Trex1 and TREX2 3'-->5' exonucleases. Characterization of the recombinant proteinsHIPK2 overexpression leads to stabilization of p53 protein and increased p53 transcriptional activity by decreasing Mdm2 protein levelsSirtuins in hematological aging and malignancyThe metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activityThe interaction of p53 with replication protein A mediates suppression of homologous recombinationActivation and activities of the p53 tumour suppressor proteinRecombinant p53 displays heterogeneity during isoelectric focusing.Applications of the human p53 knock-in (Hupki) mouse model for human carcinogen testing.Mi-2/NuRD complex making inroads into DNA-damage response pathwayp53 Ser15 phosphorylation disrupts the p53-RPA70 complex and induces RPA70-mediated DNA repair in hypoxia.Chemotherapy induced microsatellite instability and loss of heterozygosity in chromosomes 2, 5, 10, and 17 in solid tumor patients.The role of p53 in determining sensitivity to radiotherapy.Adenoviral-E2F-1 radiosensitizes p53wild-type and p53null human prostate cancer cells.Repair of radiation damage to DNA.Physical and functional interactions between human mitochondrial single-stranded DNA-binding protein and tumour suppressor p53Novel HIV-1 therapeutics through targeting altered host cell pathways.The MDM2-p53 pathway: multiple roles in kidney development.Chromosome instability and deregulated proliferation: an unavoidable duo.Tumour suppressors and cellular senescence.p53 C-terminal interaction with DNA ends and gaps has opposing effect on specific DNA binding by the core.tumor suppressor p53 binds with high affinity to CTG.CAG trinucleotide repeats and induces topological alterations in mismatched duplexes.Spatial repression of PCNA by p53 during kidney development.Administration of IκB-kinase inhibitor PS1145 enhances apoptosis in DMBA-induced tumor in male Wistar rats.p53 in the mitochondria, as a trans-acting protein, provides error-correction activities during the incorporation of non-canonical dUTP into DNA.Ribonuclease activity of p53 in cytoplasm in response to various stress signals.Down-regulation of beta-catenin by activated p53.The tumour suppressor protein p53 can repress transcription of cyclin B.DNA substrate dependence of p53-mediated regulation of double-strand break repair.Role of tumor suppressor p53 domains in selective binding to supercoiled DNA.The prolyl cis/trans isomerase cyclophilin 18 interacts with the tumor suppressor p53 and modifies its functions in cell cycle regulation and apoptosis.Dissection of the sequence-specific DNA binding and exonuclease activities reveals a superactive yet apoptotically impaired mutant p53 protein.p53 in mitochondria enhances the accuracy of DNA synthesis.Drug 9AA reactivates p21/Waf1 and Inhibits HIV-1 progeny formationPreterm labor in the absence of acute histologic chorioamnionitis is characterized by cellular senescence of the chorioamniotic membranes.Dose-dependent dual effect of HTLV-1 tax oncoprotein on p53-dependent nucleotide excision repair in human T-cells.P53 in cytoplasm may enhance the accuracy of DNA synthesis by human immunodeficiency virus type 1 reverse transcriptase.Poly(ADP-ribose) polymerase (PARP-1) and p53 independently function in regulating double-strand break repair in primate cells.Homologous recombination in extrachromosomal plasmid substrates is not suppressed by p53.Association of p53 and MSH2 with recombinative repair complexes during S phase.
P2860
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P2860
Maintenance of genomic integrity by p53: complementary roles for activated and non-activated p53.
description
1999 nî lūn-bûn
@nan
1999 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Maintenance of genomic integri ...... tivated and non-activated p53.
@ast
Maintenance of genomic integri ...... tivated and non-activated p53.
@en
type
label
Maintenance of genomic integri ...... tivated and non-activated p53.
@ast
Maintenance of genomic integri ...... tivated and non-activated p53.
@en
prefLabel
Maintenance of genomic integri ...... tivated and non-activated p53.
@ast
Maintenance of genomic integri ...... tivated and non-activated p53.
@en
P2093
P356
P1433
P1476
Maintenance of genomic integri ...... tivated and non-activated p53.
@en
P2093
Albrechtsen N
Dornreiter I
Wiesmüller L
P2888
P304
P356
10.1038/SJ.ONC.1202952
P407
P577
1999-12-01T00:00:00Z
P5875
P6179
1023665084