Inhibition of homologous recombination by variants of the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs) - Wikidata - wikimedia - TriplyDB

Inhibition of homologous recombination by variants of the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs)

Inhibition of homologous recombination by variants of the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs)

http://www.wikidata.org/entity/Q33818265

about

Concordant and opposite roles of DNA-PK and the "facilitator of chromatin transcription" (FACT) in DNA repair, apoptosis and necrosis after cisplatin Terminal DNA structure and ATP influence binding parameters of the DNA-dependent protein kinase at an early step prior to DNA synapsis.Beyond DNA repair: DNA-PK function in cancer The efficiency of homologous recombination and non-homologous end joining systems in repairing double-strand breaks during cell cycle progression The functional modulation of epigenetic regulators by alternative splicing Extensive ssDNA end formation at DNA double-strand breaks in non-homologous end-joining deficient cells during the S phase Ku and DNA-dependent protein kinase dynamic conformations and assembly regulate DNA binding and the initial non-homologous end joining complex.Gαi3 nuclear translocation causes irradiation resistance in human glioma cells.Choosing the right path: does DNA-PK help make the decision?Inhibition of homologous recombination by DNA-dependent protein kinase requires kinase activity, is titratable, and is modulated by autophosphorylation.Identification of novel radiosensitizers in a high-throughput, cell-based screen for DSB repair inhibitors.Genetic variants in DNA double-strand break repair genes and risk of salivary gland carcinoma: a case-control study N-terminal constraint activates the catalytic subunit of the DNA-dependent protein kinase in the absence of DNA or Ku.The role of Ile3434Thr XRCC7 gene polymorphism in differentiated thyroid cancer risk in an Iranian population Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template.Spontaneous tumor development in bone marrow-rescued DNA-PKcs(3A/3A) mice due to dysfunction of telomere leading strand deprotection Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining.PRKDC mutations in a SCID patient with profound neurological abnormalities.Quantitation of DNA double-strand break resection intermediates in human cells.Development of an assay to measure mutagenic non-homologous end-joining repair activity in mammalian cells.trans Autophosphorylation at DNA-dependent protein kinase's two major autophosphorylation site clusters facilitates end processing but not end joining.Unraveling the complexities of DNA-dependent protein kinase autophosphorylation.Autophosphorylation of DNA-dependent protein kinase regulates DNA end processing and may also alter double-strand break repair pathway choice.TDP1 promotes assembly of non-homologous end joining protein complexes on DNA.DNA-dependent protein kinase regulates DNA end resection in concert with Mre11-Rad50-Nbs1 (MRN) and ataxia telangiectasia-mutated (ATM).DNA-PKcs and ATM co-regulate DNA double-strand break repair Progression of chromosomal damage induced by etoposide in G2 phase in a DNA-PKcs-deficient context.

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P2860

Inhibition of homologous recombination by variants of the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs)

http://www.wikidata.org/entity/Q33818265

description

2005 nî lūn-bûn

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2005 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2005 թվականի հունվարին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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Inhibition of homologous recom ...... dent protein kinase (DNA-PKcs)

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Inhibition of homologous recom ...... dent protein kinase (DNA-PKcs)

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Inhibition of homologous recom ...... dent protein kinase (DNA-PKcs)

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PNAS.0406466102

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Proceedings of the National Academy of Sciences of the United States of America

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Inhibition of homologous recom ...... dent protein kinase (DNA-PKcs)

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Erin Convery

http://www.w3.org/2001/XMLSchema#string

Euy Kyun Shin

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Jac A Nickoloff

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Katheryn Meek

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Laurie S Davis

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Pauline Douglas

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Qi Ding

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Susan P Lees-Miller

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Wei Wang

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P2860

DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair.

Severe combined immunodeficient cells expressing mutant hRAD54 exhibit a marked DNA double-strand break repair and error-prone chromosome repair defect

A novel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia

The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination

Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV

Rad54 and DNA Ligase IV cooperate to maintain mammalian chromatid stability

The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen

Interaction of Ku protein and DNA-dependent protein kinase catalytic subunit with nucleic acids

Pathways of DNA double-strand break repair during the mammalian cell cycle

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1345-1350

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10.1073/PNAS.0406466102

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102

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8064080

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