Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template.
about
Parvovirus minute virus of mice induces a DNA damage response that facilitates viral replicationProteomic dissection of cell type-specific H2AX-interacting protein complex associated with hepatocellular carcinomaMRE11-RAD50-NBS1 is a critical regulator of FANCD2 stability and function during DNA double-strand break repairRAD50 and NBS1 form a stable complex functional in DNA binding and tetheringA supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damageRad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaksDNA resection in eukaryotes: deciding how to fix the breakDNA damage induces nucleoid compaction via the Mre11-Rad50 complex in the archaeon Haloferax volcaniiHow the fanconi anemia pathway guards the genomeATM-mediated serine 72 phosphorylation stabilizes ribonucleotide reductase small subunit p53R2 protein against MDM2 to DNA damageUbc13: the Lys63 ubiquitin chain building machineCiliogenesis and the DNA damage response: a stressful relationshipPredictive models for customizing chemotherapy in advanced non-small cell lung cancer (NSCLC)The Mre11/Rad50/Nbs1 complex: recent insights into catalytic activities and ATP-driven conformational changesCrystal Structure of the First Eubacterial Mre11 Nuclease Reveals Novel Features that May Discriminate Substrates During DNA RepairMre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break RepairNbs1 Flexibly Tethers Ctp1 and Mre11-Rad50 to Coordinate DNA Double-Strand Break Processing and RepairγH2A binds Brc1 to maintain genome integrity during S-phaseABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair.The Mre11:Rad50 Structure Shows an ATP-Dependent Molecular Clamp in DNA Double-Strand Break RepairATP driven structural changes of the bacterial Mre11:Rad50 catalytic head complexMechanism of repair of 5′-topoisomerase II–DNA adducts by mammalian tyrosyl-DNA phosphodiesterase 2Crystal structure of the NurA-dAMP-Mn2+ complexStructural mechanism of the phosphorylation-dependent dimerization of the MDC1 forkhead-associated domainDNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease ActivitiesATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signalingEnd-resection at DNA double-strand breaks in the three domains of lifeThe DNA Damage Response: Making It Safe to Play with KnivesPredictors and Modulators of Synthetic Lethality: An Update on PARP Inhibitors and Personalized MedicineRole of MRE11 in cell proliferation, tumor invasion, and DNA repair in breast cancerChk2 deficiency in Myc overexpressing lymphoma cells elicits a synergistic lethal response in combination with PARP inhibitionAncient and recent adaptive evolution of primate non-homologous end joining genesATM limits incorrect end utilization during non-homologous end joining of multiple chromosome breaksRole of mammalian Mre11 in classical and alternative nonhomologous end joiningThe MRN-CtIP pathway is required for metaphase chromosome alignment.Variants in activators and downstream targets of ATM, radiation exposure, and contralateral breast cancer risk in the WECARE study.Temporal regulation of Ig gene diversification revealed by single-cell imaging.Mre11-Rad50-Nbs complex is required to cap telomeres during Drosophila embryogenesis.A tool for enhancement and scoring of DNA repair foci.Variations in the NBN/NBS1 gene and the risk of breast cancer in non-BRCA1/2 French Canadian families with high risk of breast cancer
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P2860
Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Mre11-Rad50-Nbs1 is a keystone ...... g, and the chromatin template.
@en
type
label
Mre11-Rad50-Nbs1 is a keystone ...... g, and the chromatin template.
@en
prefLabel
Mre11-Rad50-Nbs1 is a keystone ...... g, and the chromatin template.
@en
P2860
P356
P1476
Mre11-Rad50-Nbs1 is a keystone ...... ng, and the chromatin template
@en
P2093
Jessica S Williams
R Scott Williams
P2860
P304
P356
10.1139/O07-069
P577
2007-08-01T00:00:00Z