PKCλ haploinsufficiency prevents diabetes by a mechanism involving alterations in hepatic enzymes.
about
Atypical PKC: a target for treating insulin-resistant disorders of obesity, the metabolic syndrome and type 2 diabetes mellitus.Hepatic insulin resistance in ob/ob mice involves increases in ceramide, aPKC activity, and selective impairment of Akt-dependent FoxO1 phosphorylation.Hepatic Atypical Protein Kinase C: An Inherited Survival-Longevity Gene that Now Fuels Insulin-Resistant Syndromes of Obesity, the Metabolic Syndrome and Type 2 Diabetes MellitusBMI-related progression of atypical PKC-dependent aberrations in insulin signaling through IRS-1, Akt, FoxO1 and PGC-1α in livers of obese and type 2 diabetic humansOptogenetic activation reveals distinct roles of PIP3 and Akt in adipocyte insulin action.Deletion of Protein Kinase C λ in POMC Neurons Predisposes to Diet-Induced Obesity.Atypical PKC, PKCλ/ι, activates β-secretase and increases Aβ1-40/42 and phospho-tau in mouse brain and isolated neuronal cells, and may link hyperinsulinemia and other aPKC activators to development of pathological and memory abnormalities in Alzhei
P2860
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P2860
PKCλ haploinsufficiency prevents diabetes by a mechanism involving alterations in hepatic enzymes.
description
2014 nî lūn-bûn
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2014 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2014年の論文
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2014年論文
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2014年論文
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2014年論文
@zh-hk
2014年論文
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2014年論文
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2014年论文
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name
PKCλ haploinsufficiency preven ...... lterations in hepatic enzymes.
@ast
PKCλ haploinsufficiency preven ...... lterations in hepatic enzymes.
@en
type
label
PKCλ haploinsufficiency preven ...... lterations in hepatic enzymes.
@ast
PKCλ haploinsufficiency preven ...... lterations in hepatic enzymes.
@en
prefLabel
PKCλ haploinsufficiency preven ...... lterations in hepatic enzymes.
@ast
PKCλ haploinsufficiency preven ...... lterations in hepatic enzymes.
@en
P2093
P2860
P356
P1476
PKCλ haploinsufficiency preven ...... alterations in hepatic enzymes
@en
P2093
Mackenzie Lee
Michael Leitges
Mini P Sajan
Robert A Ivey
Robert V Farese
Stephen Mastorides
Ursula Braun
Varman T Samuels
P2860
P304
P356
10.1210/ME.2014-1025
P577
2014-05-30T00:00:00Z