Role of atypical protein kinase C in activation of sterol regulatory element binding protein-1c and nuclear factor kappa B (NFkappaB) in liver of rodents used as a model of diabetes, and relationships to hyperlipidaemia and insulin resistance
about
Atypical protein kinase C in cardiometabolic abnormalitiesAtypical PKC: a target for treating insulin-resistant disorders of obesity, the metabolic syndrome and type 2 diabetes mellitus.Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesisPKCλ haploinsufficiency prevents diabetes by a mechanism involving alterations in hepatic enzymes.Insulin-regulated Srebp-1c and Pck1 mRNA expression in primary hepatocytes from zucker fatty but not lean rats is affected by feeding conditionsAkt-dependent phosphorylation of hepatic FoxO1 is compartmentalized on a WD40/ProF scaffold and is selectively inhibited by aPKC in early phases of diet-induced obesity.Requirements for pseudosubstrate arginine residues during autoinhibition and phosphatidylinositol 3,4,5-(PO₄)₃-dependent activation of atypical PKC.Insulin signaling and insulin sensitizing in muscle and liver of obese monkeys: peroxisome proliferator-activated receptor gamma agonist improves defective activation of atypical protein kinase C.Targeted Induction of Ceramide Degradation Leads to Improved Systemic Metabolism and Reduced Hepatic Steatosis.Hepatic insulin resistance in ob/ob mice involves increases in ceramide, aPKC activity, and selective impairment of Akt-dependent FoxO1 phosphorylation.PKCδ regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans.Higher protein kinase C ζ in fatty rat liver and its effect on insulin actions in primary hepatocytesHepatic Atypical Protein Kinase C: An Inherited Survival-Longevity Gene that Now Fuels Insulin-Resistant Syndromes of Obesity, the Metabolic Syndrome and Type 2 Diabetes MellitusExpression of Protein Kinase C Isoforms in Pancreatic Islets and Liver of Male Goto-Kakizaki Rats, a Model of Type 2 Diabetes.BMI-related progression of atypical PKC-dependent aberrations in insulin signaling through IRS-1, Akt, FoxO1 and PGC-1α in livers of obese and type 2 diabetic humansImpact of maternal undernutrition around the time of conception on factors regulating hepatic lipid metabolism and microRNAs in singleton and twin fetusesInsulin signalling in hepatocytes of humans with type 2 diabetes: excessive production and activity of protein kinase C-ι (PKC-ι) and dependent processes and reversal by PKC-ι inhibitors.Phosphatidylinositol-3,4,5-triphosphate and cellular signaling: implications for obesity and diabetes.Role of adipose and hepatic atypical protein kinase C lambda (PKCλ) in the development of obesity and glucose intolerance.Protein kinase Cζ exhibits constitutive phosphorylation and phosphatidylinositol-3,4,5-triphosphate-independent regulationMetabolic functions of atypical protein kinase C: "good" and "bad" as defined by nutritional status.Correction of metabolic abnormalities in a rodent model of obesity, metabolic syndrome, and type 2 diabetes mellitus by inhibitors of hepatic protein kinase C-ιHigh Fat Diet Regulation of β-Cell Proliferation and β-Cell Mass.Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's beenImpairment of insulin-stimulated glucose transport and ERK activation by adipocyte-specific knockout of PKC-λ produces a phenotype characterized by diminished adiposity and enhanced insulin suppression of hepatic gluconeogenesis.Metformin action in human hepatocytes: coactivation of atypical protein kinase C alters 5'-AMP-activated protein kinase effects on lipogenic and gluconeogenic enzyme expression.The tail wagging the dog--regulation of lipid metabolism by protein kinase C.Par-complex aPKC and Par3 cross-talk with innate immunity NF-κB pathway in epithelial cells.Low-dose aspirin ameliorated hyperlipidemia, adhesion molecule, and chemokine production induced by high-fat diet in Sprague-Dawley rats.A mathematical model of the impact of insulin secretion dynamics on selective hepatic insulin resistance.
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P2860
Role of atypical protein kinase C in activation of sterol regulatory element binding protein-1c and nuclear factor kappa B (NFkappaB) in liver of rodents used as a model of diabetes, and relationships to hyperlipidaemia and insulin resistance
description
2009 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հունիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2009
@ast
im Juni 2009 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2009/06/01)
@sk
vědecký článek publikovaný v roce 2009
@cs
wetenschappelijk artikel (gepubliceerd op 2009/06/01)
@nl
наукова стаття, опублікована в червні 2009
@uk
مقالة علمية (نشرت في يونيو 2009)
@ar
name
Role of atypical protein kinas ...... idaemia and insulin resistance
@ast
Role of atypical protein kinas ...... idaemia and insulin resistance
@en
Role of atypical protein kinas ...... idaemia and insulin resistance
@nl
type
label
Role of atypical protein kinas ...... idaemia and insulin resistance
@ast
Role of atypical protein kinas ...... idaemia and insulin resistance
@en
Role of atypical protein kinas ...... idaemia and insulin resistance
@nl
prefLabel
Role of atypical protein kinas ...... idaemia and insulin resistance
@ast
Role of atypical protein kinas ...... idaemia and insulin resistance
@en
Role of atypical protein kinas ...... idaemia and insulin resistance
@nl
P2093
P2860
P1433
P1476
Role of atypical protein kinas ...... idaemia and insulin resistance
@en
P2093
C. M. Taniguchi
M. L. Standaert
M. P. Sajan
R. V. Farese
P2860
P2888
P304
P356
10.1007/S00125-009-1336-5
P577
2009-06-01T00:00:00Z
P5875
P6179
1031615312