Fetal hemorrhage and platelet dysfunction in SLP-76-deficient mice.
about
Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeletonIdentification of a phospholipase C-gamma1 (PLC-gamma1) SH3 domain-binding site in SLP-76 required for T-cell receptor-mediated activation of PLC-gamma1 and NFATPRAM-1 is required for optimal integrin-dependent neutrophil functionPlatelet-mediated modulation of adaptive immunity: unique delivery of CD154 signal by platelet-derived membrane vesiclesEvidence that phospholipase C-gamma2 interacts with SLP-76, Syk, Lyn, LAT and the Fc receptor gamma-chain after stimulation of the collagen receptor glycoprotein VI in human plateletsInteraction of linker for activation of T cells with multiple adapter proteins in platelets activated by the glycoprotein VI-selective ligand, convulxinSLP76 and SLP65: complex regulation of signalling in lymphocytes and beyondClnk, a novel SLP-76-related adaptor molecule expressed in cytokine-stimulated hemopoietic cellsRegulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk.T cell receptor-induced activation of phospholipase C-gamma1 depends on a sequence-independent function of the P-I region of SLP-76.Adaptor FYB (Fyn-binding protein) regulates integrin-mediated adhesion and mediator release: differential involvement of the FYB SH3 domainBlood flow reprograms lymphatic vessels to blood vesselsEvidence for two distinct epitopes within collagen for activation of murine platelets.Transgenic, inducible RNAi in megakaryocytes and platelets in mice.The N-terminal SH2 domain of Syk is required for (hem)ITAM, but not integrin, signaling in mouse platelets.Recent developments in lymphocyte activation: linking kinases to downstream signaling events.Adapter molecules in T cell receptor signaling.Review article: platelet-collagen interactions: membrane receptors and intracellular signalling pathways.SLP76 integrates into the B-cell receptor signaling cascade in chronic lymphocytic leukemia cells and is associated with an aggressive disease courseSLP-76 deficiency impairs signaling via the high-affinity IgE receptor in mast cells.LAT is required for tyrosine phosphorylation of phospholipase cgamma2 and platelet activation by the collagen receptor GPVI.Modulation of T-cell receptor signal transduction by herpesvirus signaling adaptor protein.The transmembrane adapter LAT plays a central role in immune receptor signalling.The role of the adapter molecule SLP-76 in platelet function.Signalling scaffolds and adaptors in T-cell immunity.α2β1 integrin, GPVI receptor, and common FcRγ chain on mouse platelets mediate distinct responses to collagen in models of thrombosisPositive and negative regulation of T-cell activation by adaptor proteins.Adaptors as central mediators of signal transduction in immune cells.Evidence for the requirement of ITAM domains but not SLP-76/Gads interaction for integrin signaling in hematopoietic cells.Hematopoietic reconstitution of SLP-76 corrects hemostasis and platelet signaling through alpha IIb beta 3 and collagen receptorsCrucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury.Differential requirement for LAT and SLP-76 in GPVI versus T cell receptor signaling.Inactivation of c-Cbl reverses neonatal lethality and T cell developmental arrest of SLP-76-deficient mice.Critical role for the mitochondrial permeability transition pore and cyclophilin D in platelet activation and thrombosis.Platelet-derived CD154 enables T-cell priming and protection against Listeria monocytogenes challengeThe SYK tyrosine kinase: a crucial player in diverse biological functions.Immune functions in mice lacking Clnk, an SLP-76-related adaptor expressed in a subset of immune cells.Requirements of SLP76 tyrosines in ITAM and integrin receptor signaling and in platelet function in vivo.Adapter proteins SLP-76 and BLNK both are expressed by murine macrophages and are linked to signaling via Fcgamma receptors I and II/IIIPlatelet immunoreceptor tyrosine-based activation motif (ITAM) signaling and vascular integrity.
P2860
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P2860
Fetal hemorrhage and platelet dysfunction in SLP-76-deficient mice.
description
1999 nî lūn-bûn
@nan
1999 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Fetal hemorrhage and platelet dysfunction in SLP-76-deficient mice.
@ast
Fetal hemorrhage and platelet dysfunction in SLP-76-deficient mice.
@en
type
label
Fetal hemorrhage and platelet dysfunction in SLP-76-deficient mice.
@ast
Fetal hemorrhage and platelet dysfunction in SLP-76-deficient mice.
@en
prefLabel
Fetal hemorrhage and platelet dysfunction in SLP-76-deficient mice.
@ast
Fetal hemorrhage and platelet dysfunction in SLP-76-deficient mice.
@en
P2093
P2860
P50
P356
P1476
Fetal hemorrhage and platelet dysfunction in SLP-76-deficient mice
@en
P2093
P2860
P356
10.1172/JCI5317
P407
P577
1999-01-01T00:00:00Z