Membrane topological analysis of the proton-coupled folate transporter (PCFT-SLC46A1) by the substituted cysteine accessibility method.
about
Biology of the major facilitative folate transporters SLC19A1 and SLC46A1Substituted cysteine accessibility reveals a novel transmembrane 2-3 reentrant loop and functional role for transmembrane domain 2 in the human proton-coupled folate transporter.The proton-coupled folate transporter: physiological and pharmacological roles.Properties of the Arg376 residue of the proton-coupled folate transporter (PCFT-SLC46A1) and a glutamine mutant causing hereditary folate malabsorptionMechanisms of membrane transport of folates into cells and across epithelia.Identification and functional impact of homo-oligomers of the human proton-coupled folate transporter.The human proton-coupled folate transporter: Biology and therapeutic applications to cancer.Folate and thiamine transporters mediated by facilitative carriers (SLC19A1-3 and SLC46A1) and folate receptors.Delineating the extracellular water-accessible surface of the proton-coupled folate transporter.The intestinal absorption of folates.Functional roles of aspartate residues of the proton-coupled folate transporter (PCFT-SLC46A1); a D156Y mutation causing hereditary folate malabsorption.Vulnerability of the cysteine-less proton-coupled folate transporter (PCFT-SLC46A1) to mutational stress associated with the substituted cysteine accessibility method.Control of intracellular heme levels: heme transporters and heme oxygenasesIdentification of novel mutations in the proton-coupled folate transporter (PCFT-SLC46A1) associated with hereditary folate malabsorptionRandom mutagenesis of the proton-coupled folate transporter (SLC46A1), clustering of mutations, and the bases for associated losses of functionIdentification of Tyr residues that enhance folate substrate binding and constrain oscillation of the proton-coupled folate transporter (PCFT-SLC46A1).A P425R mutation of the proton-coupled folate transporter causing hereditary folate malabsorption produces a highly selective alteration in folate binding.Identification of a functionally critical GXXG motif and its relationship to the folate binding site of the proton-coupled folate transporter (PCFT-SLC46A1)Functional roles of the A335 and G338 residues of the proton-coupled folate transporter (PCFT-SLC46A1) mutated in hereditary folate malabsorption.Expression in Sf9 insect cells, purification and functional reconstitution of the human proton-coupled folate transporter (PCFT, SLC46A1).Identification of an Extracellular Gate for the Proton-coupled Folate Transporter (PCFT-SLC46A1) by Cysteine Cross-linking.Role of the fourth transmembrane domain in proton-coupled folate transporter function as assessed by the substituted cysteine accessibility method.Role of the tryptophan residues in proton-coupled folate transporter (PCFT-SLC46A1) function.Functional and mechanistic roles of the human proton-coupled folate transporter transmembrane domain 6-7 linker.The major facilitative folate transporters solute carrier 19A1 and solute carrier 46A1: biology and role in antifolate chemotherapy of cancer.Residues in the eighth transmembrane domain of the proton-coupled folate transporter (SLC46A1) play an important role in defining the aqueous translocation pathway and in folate substrate binding.Impact of posttranslational modifications of engineered cysteines on the substituted cysteine accessibility method: evidence for glutathionylation.The proton-coupled folate transporter (PCFT-SLC46A1) and the syndrome of systemic and cerebral folate deficiency of infancy: Hereditary folate malabsorption.Experimentally optimized threading structures of the proton-coupled folate transporter.The monomeric state of the proton-coupled folate transporter represents the functional unit in the plasma membrane.The promise and challenges of exploiting the proton-coupled folate transporter for selective therapeutic targeting of cancer.
P2860
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P2860
Membrane topological analysis of the proton-coupled folate transporter (PCFT-SLC46A1) by the substituted cysteine accessibility method.
description
2010 nî lūn-bûn
@nan
2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Membrane topological analysis ...... cysteine accessibility method.
@ast
Membrane topological analysis ...... cysteine accessibility method.
@en
type
label
Membrane topological analysis ...... cysteine accessibility method.
@ast
Membrane topological analysis ...... cysteine accessibility method.
@en
prefLabel
Membrane topological analysis ...... cysteine accessibility method.
@ast
Membrane topological analysis ...... cysteine accessibility method.
@en
P2093
P2860
P356
P1433
P1476
Membrane topological analysis ...... cysteine accessibility method.
@en
P2093
Ersin Selcuk Unal
I David Goldman
Rongbao Zhao
P2860
P304
P356
10.1021/BI9021439
P407
P577
2010-04-01T00:00:00Z