Random mutagenesis of the proton-coupled folate transporter (SLC46A1), clustering of mutations, and the bases for associated losses of function

Random mutagenesis of the proton-coupled folate transporter (SLC46A1), clustering of mutations, and the bases for associated losses of function

Item
http://www.wikidata.org/entity/Q35085104
Biology of the major facilitative folate transporters SLC19A1 and SLC46A1The proton-coupled folate transporter: physiological and pharmacological roles.The human proton-coupled folate transporter: Biology and therapeutic applications to cancer.Structural determinants of human proton-coupled folate transporter oligomerization: role of GXXXG motifs and identification of oligomeric interfaces at transmembrane domains 3 and 6Identification of Tyr residues that enhance folate substrate binding and constrain oscillation of the proton-coupled folate transporter (PCFT-SLC46A1).A P425R mutation of the proton-coupled folate transporter causing hereditary folate malabsorption produces a highly selective alteration in folate binding.Identification of a functionally critical GXXG motif and its relationship to the folate binding site of the proton-coupled folate transporter (PCFT-SLC46A1)Functional roles of the A335 and G338 residues of the proton-coupled folate transporter (PCFT-SLC46A1) mutated in hereditary folate malabsorption.Role of the fourth transmembrane domain in proton-coupled folate transporter function as assessed by the substituted cysteine accessibility method.Inhibition of the proton-coupled folate transporter (PCFT-SLC46A1) by bicarbonate and other anions.Role of the tryptophan residues in proton-coupled folate transporter (PCFT-SLC46A1) function.The major facilitative folate transporters solute carrier 19A1 and solute carrier 46A1: biology and role in antifolate chemotherapy of cancer.Evidence of a Substrate-Discriminating Entrance Channel in the Lower Porter Domain of the Multidrug Resistance Efflux Pump AcrBThe promise and challenges of exploiting the proton-coupled folate transporter for selective therapeutic targeting of cancer.
P2860

Random mutagenesis of the proton-coupled folate transporter (SLC46A1), clustering of mutations, and the bases for associated losses of function

Item
http://www.wikidata.org/entity/Q35085104
description
2011 nî lūn-bûn
@nan
2011 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Random mutagenesis of the prot ...... associated losses of function
@ast
Random mutagenesis of the prot ...... associated losses of function
@en
type
label
Random mutagenesis of the prot ...... associated losses of function
@ast
Random mutagenesis of the prot ...... associated losses of function
@en
prefLabel
Random mutagenesis of the prot ...... associated losses of function
@ast
Random mutagenesis of the prot ...... associated losses of function
@en
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698
P932
P356
P1433
P1476
Random mutagenesis of the prot ...... associated losses of function
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698
P932