Properties of the Arg376 residue of the proton-coupled folate transporter (PCFT-SLC46A1) and a glutamine mutant causing hereditary folate malabsorption
about
Biology of the major facilitative folate transporters SLC19A1 and SLC46A1Substituted cysteine accessibility reveals a novel transmembrane 2-3 reentrant loop and functional role for transmembrane domain 2 in the human proton-coupled folate transporter.The proton-coupled folate transporter: physiological and pharmacological roles.Prevalence of a loss-of-function mutation in the proton-coupled folate transporter gene (PCFT-SLC46A1) causing hereditary folate malabsorption in Puerto Rico.Mechanisms of membrane transport of folates into cells and across epithelia.Identification and functional impact of homo-oligomers of the human proton-coupled folate transporter.The human proton-coupled folate transporter: Biology and therapeutic applications to cancer.Functional roles of aspartate residues of the proton-coupled folate transporter (PCFT-SLC46A1); a D156Y mutation causing hereditary folate malabsorption.Structural determinants of human proton-coupled folate transporter oligomerization: role of GXXXG motifs and identification of oligomeric interfaces at transmembrane domains 3 and 6Vulnerability of the cysteine-less proton-coupled folate transporter (PCFT-SLC46A1) to mutational stress associated with the substituted cysteine accessibility method.Identification of novel mutations in the proton-coupled folate transporter (PCFT-SLC46A1) associated with hereditary folate malabsorptionRandom mutagenesis of the proton-coupled folate transporter (SLC46A1), clustering of mutations, and the bases for associated losses of functionIdentification of Tyr residues that enhance folate substrate binding and constrain oscillation of the proton-coupled folate transporter (PCFT-SLC46A1).A P425R mutation of the proton-coupled folate transporter causing hereditary folate malabsorption produces a highly selective alteration in folate binding.Identification of a functionally critical GXXG motif and its relationship to the folate binding site of the proton-coupled folate transporter (PCFT-SLC46A1)Functional roles of the A335 and G338 residues of the proton-coupled folate transporter (PCFT-SLC46A1) mutated in hereditary folate malabsorption.Expression in Sf9 insect cells, purification and functional reconstitution of the human proton-coupled folate transporter (PCFT, SLC46A1).Identification of an Extracellular Gate for the Proton-coupled Folate Transporter (PCFT-SLC46A1) by Cysteine Cross-linking.Role of the fourth transmembrane domain in proton-coupled folate transporter function as assessed by the substituted cysteine accessibility method.Role of the tryptophan residues in proton-coupled folate transporter (PCFT-SLC46A1) function.Functional and mechanistic roles of the human proton-coupled folate transporter transmembrane domain 6-7 linker.The major facilitative folate transporters solute carrier 19A1 and solute carrier 46A1: biology and role in antifolate chemotherapy of cancer.The proton-coupled folate transporter (PCFT-SLC46A1) and the syndrome of systemic and cerebral folate deficiency of infancy: Hereditary folate malabsorption.The monomeric state of the proton-coupled folate transporter represents the functional unit in the plasma membrane.The promise and challenges of exploiting the proton-coupled folate transporter for selective therapeutic targeting of cancer.
P2860
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P2860
Properties of the Arg376 residue of the proton-coupled folate transporter (PCFT-SLC46A1) and a glutamine mutant causing hereditary folate malabsorption
description
2010 nî lūn-bûn
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2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2010年の論文
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2010年論文
@yue
2010年論文
@zh-hant
2010年論文
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2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
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name
Properties of the Arg376 resid ...... ereditary folate malabsorption
@ast
Properties of the Arg376 resid ...... ereditary folate malabsorption
@en
Properties of the Arg376 residue of the proton-coupled folate transporter
@nl
type
label
Properties of the Arg376 resid ...... ereditary folate malabsorption
@ast
Properties of the Arg376 resid ...... ereditary folate malabsorption
@en
Properties of the Arg376 residue of the proton-coupled folate transporter
@nl
prefLabel
Properties of the Arg376 resid ...... ereditary folate malabsorption
@ast
Properties of the Arg376 resid ...... ereditary folate malabsorption
@en
Properties of the Arg376 residue of the proton-coupled folate transporter
@nl
P2093
P2860
P1476
Properties of the Arg376 resid ...... ereditary folate malabsorption
@en
P2093
Andreas Fulterer
Daniel Shin
Ersin Selcuk Unal
I David Goldman
Juliana Teo
Kris Mahadeo
Michael F Romero
Min-Hwang Chang
Ndeye Diop-Bove
Rongbao Zhao
P2860
P304
P356
10.1152/AJPCELL.00113.2010
P577
2010-08-04T00:00:00Z