Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8
about
Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modificationsFine-tuning the ubiquitin code at DNA double-strand breaks: deubiquitinating enzymes at workEpigenetic Codes Programing Class Switch RecombinationModeling the study of DNA damage responses in micePTIP promotes chromatin changes critical for immunoglobulin class switch recombinationDNA-damage response and repair activities at uncapped telomeres depend on RNF8The histone methyltransferase MMSET regulates class switch recombinationUSP28 is recruited to sites of DNA damage by the tandem BRCT domains of 53BP1 but plays a minor role in double-strand break metabolism.Histone H2A and H2B are monoubiquitinated at AID-targeted loci.An RNF168 fragment defective for focal accumulation at DNA damage is proficient for inhibition of homologous recombination in BRCA1 deficient cells.Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndromeUBR2 of the N-end rule pathway is required for chromosome stability via histone ubiquitylation in spermatocytes and somatic cells.Synergistic interaction of Rnf8 and p53 in the protection against genomic instability and tumorigenesis.DNA double-strand break signaling and human disorders.Recruitment kinetics of DNA repair proteins Mdc1 and Rad52 but not 53BP1 depend on damage complexity.Ubiquitin makes its mark on immune regulation.RNF8-dependent histone ubiquitination during DNA damage response and spermatogenesisMDC1 directs chromosome-wide silencing of the sex chromosomes in male germ cellsCritical roles of ring finger protein RNF8 in replication stress responses.Chfr and RNF8 synergistically regulate ATM activation.Regulation of DNA end joining, resection, and immunoglobulin class switch recombination by 53BP1.Regulation of 53BP1 protein stability by RNF8 and RNF168 is important for efficient DNA double-strand break repairEctopic expression of RNF168 and 53BP1 increases mutagenic but not physiological non-homologous end joining.AIDing antibody diversity by error-prone mismatch repair.RAP80 is critical in maintaining genomic stability and suppressing tumor development.RNF8 regulates active epigenetic modifications and escape gene activation from inactive sex chromosomes in post-meiotic spermatids.Immunoglobulin class-switch DNA recombination: induction, targeting and beyond.Loss of the Ubiquitin-conjugating Enzyme UBE2W Results in Susceptibility to Early Postnatal Lethality and Defects in Skin, Immune, and Male Reproductive Systems.RNF8 deficiency results in neurodegeneration in mice.RNF168 forms a functional complex with RAD6 during the DNA damage responseA Damage-Independent Role for 53BP1 that Impacts Break Order and Igh Architecture during Class Switch RecombinationDetermining timing of hepatectomy for colorectal cancer with distant metastasis according to imaging-based tumor shrinkage ratio.RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks.AIDing Chromatin and Transcription-Coupled Orchestration of Immunoglobulin Class-Switch Recombination.DNA double-strand break repair, immunodeficiency and the RIDDLE syndrome.Fusing telomeres with RNF8.Rad18 and Rnf8 facilitate homologous recombination by two distinct mechanisms, promoting Rad51 focus formation and suppressing the toxic effect of nonhomologous end joining.RNAi silencing targeting RNF8 enhances radiosensitivity of a non-small cell lung cancer cell line A549.Genetic association study of RNF8 and BRDT variants with non-obstructive azoospermia in the Chinese Han population.Function of RAD6B and RNF8 in spermatogenesis.
P2860
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P2860
Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8
description
2010 nî lūn-bûn
@nan
2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8
@ast
Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8
@en
type
label
Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8
@ast
Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8
@en
prefLabel
Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8
@ast
Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8
@en
P2093
P2860
P356
P1476
Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8
@en
P2093
André Nussenzweig
Hua-Tang Chen
Isaac A Klein
Juan L R Barbancho
Junjie Chen
Margarida Almeida Santos
Michael S Y Huen
Michel C Nussenzweig
Mila Jankovic
Nancy Wong
P2860
P304
P356
10.1084/JEM.20092308
P407
P577
2010-04-12T00:00:00Z