Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8 - Wikidata - wikimedia - TriplyDB

Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8

Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8

http://www.wikidata.org/entity/Q33839896

about

Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications Fine-tuning the ubiquitin code at DNA double-strand breaks: deubiquitinating enzymes at work Epigenetic Codes Programing Class Switch Recombination Modeling the study of DNA damage responses in mice PTIP promotes chromatin changes critical for immunoglobulin class switch recombination DNA-damage response and repair activities at uncapped telomeres depend on RNF8 The histone methyltransferase MMSET regulates class switch recombination USP28 is recruited to sites of DNA damage by the tandem BRCT domains of 53BP1 but plays a minor role in double-strand break metabolism.Histone H2A and H2B are monoubiquitinated at AID-targeted loci.An RNF168 fragment defective for focal accumulation at DNA damage is proficient for inhibition of homologous recombination in BRCA1 deficient cells.Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome UBR2 of the N-end rule pathway is required for chromosome stability via histone ubiquitylation in spermatocytes and somatic cells.Synergistic interaction of Rnf8 and p53 in the protection against genomic instability and tumorigenesis.DNA double-strand break signaling and human disorders.Recruitment kinetics of DNA repair proteins Mdc1 and Rad52 but not 53BP1 depend on damage complexity.Ubiquitin makes its mark on immune regulation.RNF8-dependent histone ubiquitination during DNA damage response and spermatogenesis MDC1 directs chromosome-wide silencing of the sex chromosomes in male germ cells Critical roles of ring finger protein RNF8 in replication stress responses.Chfr and RNF8 synergistically regulate ATM activation.Regulation of DNA end joining, resection, and immunoglobulin class switch recombination by 53BP1.Regulation of 53BP1 protein stability by RNF8 and RNF168 is important for efficient DNA double-strand break repair Ectopic expression of RNF168 and 53BP1 increases mutagenic but not physiological non-homologous end joining.AIDing antibody diversity by error-prone mismatch repair.RAP80 is critical in maintaining genomic stability and suppressing tumor development.RNF8 regulates active epigenetic modifications and escape gene activation from inactive sex chromosomes in post-meiotic spermatids.Immunoglobulin class-switch DNA recombination: induction, targeting and beyond.Loss of the Ubiquitin-conjugating Enzyme UBE2W Results in Susceptibility to Early Postnatal Lethality and Defects in Skin, Immune, and Male Reproductive Systems.RNF8 deficiency results in neurodegeneration in mice.RNF168 forms a functional complex with RAD6 during the DNA damage response A Damage-Independent Role for 53BP1 that Impacts Break Order and Igh Architecture during Class Switch Recombination Determining timing of hepatectomy for colorectal cancer with distant metastasis according to imaging-based tumor shrinkage ratio.RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks.AIDing Chromatin and Transcription-Coupled Orchestration of Immunoglobulin Class-Switch Recombination.DNA double-strand break repair, immunodeficiency and the RIDDLE syndrome.Fusing telomeres with RNF8.Rad18 and Rnf8 facilitate homologous recombination by two distinct mechanisms, promoting Rad51 focus formation and suppressing the toxic effect of nonhomologous end joining.RNAi silencing targeting RNF8 enhances radiosensitivity of a non-small cell lung cancer cell line A549.Genetic association study of RNF8 and BRDT variants with non-obstructive azoospermia in the Chinese Han population.Function of RAD6B and RNF8 in spermatogenesis.

P2860

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P2860

Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8

http://www.wikidata.org/entity/Q33839896

description

2010 nî lūn-bûn

@nan

2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8

@ast

Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8

@en

type

label

Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8

@ast

Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8

@en

prefLabel

Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8

@ast

Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8

@en

P1433

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P1433

Journal of Experimental Medicine

P1476

Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8

@en

P2093

André Nussenzweig

http://www.w3.org/2001/XMLSchema#string

Hua-Tang Chen

http://www.w3.org/2001/XMLSchema#string

Isaac A Klein

http://www.w3.org/2001/XMLSchema#string

Juan L R Barbancho

http://www.w3.org/2001/XMLSchema#string

Junjie Chen

http://www.w3.org/2001/XMLSchema#string

Margarida Almeida Santos

http://www.w3.org/2001/XMLSchema#string

Michael S Y Huen

http://www.w3.org/2001/XMLSchema#string

Michel C Nussenzweig

http://www.w3.org/2001/XMLSchema#string

Mila Jankovic

http://www.w3.org/2001/XMLSchema#string

Nancy Wong

http://www.w3.org/2001/XMLSchema#string

P2860

RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly

The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase

Response to RAG-mediated VDJ cleavage by NBS1 and gamma-H2AX

AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching

Genomic instability in mice lacking histone H2AX

The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombination

53BP1 is required for class switch recombination.

P304

973-981

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1084/JEM.20092308

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P407

P433

5

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P478

207

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P50

Andrés J López-Contreras

Oscar Fernandez-Capetillo

P577

2010-04-12T00:00:00Z

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P5875

43130933

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P698

20385748

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P932

2867275

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