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A feed-forward loop amplifies nutritional regulation of PNPLA3

A feed-forward loop amplifies nutritional regulation of PNPLA3

http://www.wikidata.org/entity/Q33842841

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PNPLA3 mediates hepatocyte triacylglycerol remodeling Nonalcoholic fatty liver disease: a comprehensive review of a growing epidemic Liver x receptors in atherosclerosis and inflammation A Meta-Analysis of the Association Between the I148M Variant of Patatin-Like Phospholipase Domain Containing 3 Gene and the Presence of Chronic Hepatitis C Alcoholic liver disease and hepatitis C virus infection Modulation of host lipid metabolism by hepatitis C virus: Role of new therapies Genetic Factors in the Pathogenesis of Nonalcoholic Fatty Liver and Steatohepatitis Impact of IL28B, ITPA and PNPLA3 genetic variants on therapeutic outcome and progression of hepatitis C virus infection Composite prognostic models across the non-alcoholic fatty liver disease spectrum: Clinical application in developing countries Clinical features of pediatric nonalcoholic fatty liver disease: a need for increased awareness and a consensus for screening.Insulin resistance in clinical and experimental alcoholic liver disease Pediatric fatty liver disease: role of ethnicity and genetics How Useful Are Monogenic Rodent Models for the Study of Human Non-Alcoholic Fatty Liver Disease?Hepatic lipid droplet biology: Getting to the root of fatty liver A cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: Application to acetaminophen Sexually dimorphic genome-wide binding of retinoid X receptor alpha (RXRα) determines male-female differences in the expression of hepatic lipid processing genes in mice Mechanisms for insulin resistance: common threads and missing links Adiponutrin functions as a nutritionally regulated lysophosphatidic acid acyltransferase.Omic studies reveal the pathogenic lipid droplet proteins in non-alcoholic fatty liver disease.PNPLA3/adiponutrin functions in lipid droplet formation.Pediatric non-alcoholic fatty liver disease: New insights and future directions Pediatric Non-Alcoholic Fatty Liver Disease The Association between Pediatric NAFLD and Common Genetic Variants.Metabolic profiling reveals that PNPLA3 induces widespread effects on metabolism beyond triacylglycerol remodeling in Huh-7 hepatoma cells.PNPLA3 has retinyl-palmitate lipase activity in human hepatic stellate cells Nonalcoholic Fatty Liver Disease: Epidemiology, Pathogenesis, Natural History, Diagnosis, and Current Treatment Options.Patatin-like phospholipase domain-containing 3/adiponutrin deficiency in mice is not associated with fatty liver disease.Hepatocellular carcinoma in nonalcoholic fatty liver: role of environmental and genetic factors.Toward a unifying hypothesis of metabolic syndrome.Hepatic fat accumulation is modulated by the interaction between the rs738409 variant in the PNPLA3 gene and the dietary omega6/omega3 PUFA intake Association between the PNPLA3 I148M polymorphism and non-alcoholic fatty liver disease in the Uygur and Han ethnic groups of northwestern China.Increased hepatic fat in overweight Hispanic youth influenced by interaction between genetic variation in PNPLA3 and high dietary carbohydrate and sugar consumption Variant adiponutrin confers genetic protection against cholestatic itch Paradoxical lower serum triglyceride levels and higher type 2 diabetes mellitus susceptibility in obese individuals with the PNPLA3 148M variant.Correlation between patatin-like phospholipase domain-containing protein 3 gene polymorphisms and liver cirrhosis in a chinese han population with chronic hepatitis B Effects of PNPLA3 on liver fat and metabolic profile in Hispanic children and adolescents.Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome.Genetic variants in PNPLA3 and risk of non-alcoholic fatty liver disease in a Han Chinese population.Inactivation of Tm6sf2, a Gene Defective in Fatty Liver Disease, Impairs Lipidation but Not Secretion of Very Low Density Lipoproteins.TTC39B deficiency stabilizes LXR reducing both atherosclerosis and steatohepatitis.

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P2860

A feed-forward loop amplifies nutritional regulation of PNPLA3

http://www.wikidata.org/entity/Q33842841

description

2010 nî lūn-bûn

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2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2010年の論文

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2010年論文

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2010年論文

@zh-hant

2010年論文

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2010年論文

@zh-mo

2010年論文

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2010年论文

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name

A feed-forward loop amplifies nutritional regulation of PNPLA3

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type

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A feed-forward loop amplifies nutritional regulation of PNPLA3

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A feed-forward loop amplifies nutritional regulation of PNPLA3

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Proceedings of the National Academy of Sciences of the United States of America

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A feed-forward loop amplifies nutritional regulation of PNPLA3

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P2093

Helen H Hobbs

http://www.w3.org/2001/XMLSchema#string

John Zhong Li

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Jonathan C Cohen

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Shaoqing He

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Timothy F Osborne

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Yongcheng Huang

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Young-Kyo Seo

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P2860

Role of LXRs in control of lipogenesis

Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities

Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter

Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta

Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions

Unsaturated fatty acids inhibit proteasomal degradation of Insig-1 at a postubiquitination step

Structure and function of the feed-forward loop network motif

The crystal structure, mutagenesis, and activity studies reveal that patatin is a lipid acyl hydrolase with a Ser-Asp catalytic dyad

Characterization of the human patatin-like phospholipase family

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