Patatin-like phospholipase domain-containing 3/adiponutrin deficiency in mice is not associated with fatty liver disease. - Wikidata - wikimedia - TriplyDB

Patatin-like phospholipase domain-containing 3/adiponutrin deficiency in mice is not associated with fatty liver disease.

Patatin-like phospholipase domain-containing 3/adiponutrin deficiency in mice is not associated with fatty liver disease.

http://www.wikidata.org/entity/Q34101705

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PNPLA3 mediates hepatocyte triacylglycerol remodeling Insulin resistance in clinical and experimental alcoholic liver disease Studying non-alcoholic fatty liver disease with zebrafish: a confluence of optics, genetics, and physiology Targeting autophagy for the treatment of liver diseases Pediatric fatty liver disease: role of ethnicity and genetics Alcoholic liver disease: pathogenesis and new therapeutic targets.Molecular Pathogenesis of NASH How Useful Are Monogenic Rodent Models for the Study of Human Non-Alcoholic Fatty Liver Disease?Sexually dimorphic genome-wide binding of retinoid X receptor alpha (RXRα) determines male-female differences in the expression of hepatic lipid processing genes in mice Mechanisms for insulin resistance: common threads and missing links Adiponutrin functions as a nutritionally regulated lysophosphatidic acid acyltransferase.Omic studies reveal the pathogenic lipid droplet proteins in non-alcoholic fatty liver disease.PNPLA3/adiponutrin functions in lipid droplet formation.The PNPLA3 rs738409 148M/M genotype is a risk factor for liver cancer in alcoholic cirrhosis but shows no or weak association in hepatitis C cirrhosis.Hepatic fat accumulation is modulated by the interaction between the rs738409 variant in the PNPLA3 gene and the dietary omega6/omega3 PUFA intake Paradoxical lower serum triglyceride levels and higher type 2 diabetes mellitus susceptibility in obese individuals with the PNPLA3 148M variant.The I148M PNPLA3 polymorphism influences serum adiponectin in patients with fatty liver and healthy controls.Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome.Inactivation of Tm6sf2, a Gene Defective in Fatty Liver Disease, Impairs Lipidation but Not Secretion of Very Low Density Lipoproteins.Lipolysis - a highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores.Genetic determinants of hepatic steatosis in man.Pnpla3I148M knockin mice accumulate PNPLA3 on lipid droplets and develop hepatic steatosis Increased very low density lipoprotein (VLDL) secretion, hepatic steatosis, and insulin resistance.Association between patatin-like phospholipase domain containing 3 gene (PNPLA3) polymorphisms and nonalcoholic fatty liver disease: a HuGE review and meta-analysis.Mammalian triacylglycerol metabolism: synthesis, lipolysis, and signaling Identification of eQTLs for hepatic Xbp1s and Socs3 gene expression in mice fed a high-fat, high-caloric diet.The metabolic serine hydrolases and their functions in mammalian physiology and disease.Expression and characterization of a PNPLA3 protein isoform (I148M) associated with nonalcoholic fatty liver disease.Human fatty liver disease: old questions and new insights PNPLA3 genetic variation in alcoholic steatosis and liver disease progression.Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents FAT SIGNALS--lipases and lipolysis in lipid metabolism and signaling.The role of mitochondrial genomics in patients with non-alcoholic steatohepatitis (NASH).Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis.PNPLA3, the triacylglycerol synthesis/hydrolysis/storage dilemma, and nonalcoholic fatty liver disease.Pathophysiology of lipid droplet proteins in liver diseases.Role of patatin-like phospholipase domain-containing 3 on lipid-induced hepatic steatosis and insulin resistance in rats Increased activin bioavailability enhances hepatic insulin sensitivity while inducing hepatic steatosis in male mice.Insights from Genome-Wide Association Analyses of Nonalcoholic Fatty Liver Disease.Lipid droplets and cellular lipid metabolism.

P2860

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P2860

Patatin-like phospholipase domain-containing 3/adiponutrin deficiency in mice is not associated with fatty liver disease.

http://www.wikidata.org/entity/Q34101705

description

2010 nî lūn-bûn

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2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Patatin-like phospholipase dom ...... ated with fatty liver disease.

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Patatin-like phospholipase dom ...... ated with fatty liver disease.

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Patatin-like phospholipase dom ...... ated with fatty liver disease.

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type

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Patatin-like phospholipase dom ...... ated with fatty liver disease.

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Patatin-like phospholipase dom ...... ated with fatty liver disease.

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Patatin-like phospholipase dom ...... ated with fatty liver disease.

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Patatin-like phospholipase dom ...... ated with fatty liver disease.

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Patatin-like phospholipase dom ...... ated with fatty liver disease.

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Patatin-like phospholipase dom ...... ated with fatty liver disease.

@en

P2093

Benny Chang

http://www.w3.org/2001/XMLSchema#string

Lan Li

http://www.w3.org/2001/XMLSchema#string

Lawrence Chan

http://www.w3.org/2001/XMLSchema#string

Weiqin Chen

http://www.w3.org/2001/XMLSchema#string

P2860

Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

The crystal structure, mutagenesis, and activity studies reveal that patatin is a lipid acyl hydrolase with a Ser-Asp catalytic dyad

Adiponutrin, a transmembrane protein corresponding to a novel dietary- and obesity-linked mRNA specifically expressed in the adipose lineage

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease.

Genetic variance in the adiponutrin gene family and childhood obesity.

A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis.

A feed-forward loop amplifies nutritional regulation of PNPLA3

Enzymes of triacylglycerol synthesis and their regulation.

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1134-1142

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scholarly article

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10.1002/HEP.23812

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3

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52

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2010-09-01T00:00:00Z

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20648554

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2932863

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