Herpes simplex virus 1 ICP22 regulates the accumulation of a shorter mRNA and of a truncated US3 protein kinase that exhibits altered functions
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Mapping of key functions of the herpes simplex virus 1 U(S)3 protein kinase: the U(S)3 protein can form functional heteromultimeric structures derived from overlapping truncated polypeptidesThe novel HSV-1 US5-1 RNA is transcribed off a domain encoding US5, US4, US3, US2 and alpha22.Herpes simplex virus 1-encoded protein kinase UL13 phosphorylates viral Us3 protein kinase and regulates nuclear localization of viral envelopment factors UL34 and UL31Roles for herpes simplex virus type 1 UL34 and US3 proteins in disrupting the nuclear lamina during herpes simplex virus type 1 egress.Protein kinase B/Akt is present in activated form throughout the entire replicative cycle of deltaU(S)3 mutant virus but only at early times after infection with wild-type herpes simplex virus 1U(S)3 and U(S)3.5 protein kinases of herpes simplex virus 1 differ with respect to their functions in blocking apoptosis and in virion maturation and egress.ICP0 and the US3 protein kinase of herpes simplex virus 1 independently block histone deacetylation to enable gene expression.ORF66 protein kinase function is required for T-cell tropism of varicella-zoster virus in vivoSequence variation in the herpes simplex virus U(S)1 ocular virulence determinant.Glycoprotein M of herpes simplex virus 1 is incorporated into virions during budding at the inner nuclear membrane.US3 of herpes simplex virus type 1 encodes a promiscuous protein kinase that phosphorylates and alters localization of lamin A/C in infected cellsCathepsin B mediates cleavage of herpes simplex virus type 1 origin binding protein (OBP) to yield OBPC-1, and cleavage is dependent upon viral DNA replication.In transduced cells, the US3 protein kinase of herpes simplex virus 1 precludes activation and induction of apoptosis by transfected procaspase 3.Expression of gamma interferon-dependent genes is blocked independently by virion host shutoff RNase and by US3 protein kinaseIdentification of a physiological phosphorylation site of the herpes simplex virus 1-encoded protein kinase Us3 which regulates its optimal catalytic activity in vitro and influences its function in infected cells.Role of cdk9 in the optimization of expression of the genes regulated by ICP22 of herpes simplex virus 1Phosphorylation of the U(L)31 protein of herpes simplex virus 1 by the U(S)3-encoded kinase regulates localization of the nuclear envelopment complex and egress of nucleocapsids.Viral serine/threonine protein kinasesHyperphosphorylation of histone deacetylase 2 by alphaherpesvirus US3 kinases.Herpes simplex virus type 1 C-terminal variants of the origin binding protein (OBP), OBPC-1 and OBPC-2, cooperatively regulate viral DNA levels in vitro, and OBPC-2 affects mortality in mice.Varicella-zoster virus ORF63 inhibits apoptosis of primary human neurons.
P2860
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P2860
Herpes simplex virus 1 ICP22 regulates the accumulation of a shorter mRNA and of a truncated US3 protein kinase that exhibits altered functions
description
2005 nî lūn-bûn
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2005 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2005年の論文
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2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
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name
Herpes simplex virus 1 ICP22 r ...... hat exhibits altered functions
@ast
Herpes simplex virus 1 ICP22 r ...... hat exhibits altered functions
@en
type
label
Herpes simplex virus 1 ICP22 r ...... hat exhibits altered functions
@ast
Herpes simplex virus 1 ICP22 r ...... hat exhibits altered functions
@en
prefLabel
Herpes simplex virus 1 ICP22 r ...... hat exhibits altered functions
@ast
Herpes simplex virus 1 ICP22 r ...... hat exhibits altered functions
@en
P2860
P1433
P1476
Herpes simplex virus 1 ICP22 r ...... hat exhibits altered functions
@en
P2093
Alice P W Poon
P2860
P304
P356
10.1128/JVI.79.13.8470-8479.2005
P577
2005-07-01T00:00:00Z