Resistance to type 1 diabetes induction in 12-lipoxygenase knockout mice.
about
Mammalian lipoxygenases and their biological relevanceBiosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acidThe expression and function of a group VIA calcium-independent phospholipase A2 (iPLA2beta) in beta-cellsFunctional and pathological roles of the 12- and 15-lipoxygenases12/15-Lipoxygenase signaling in the endoplasmic reticulum stress response.Adeno-associated virus vector mediated gene transfer to pancreatic beta cells.Increased production of 12/15 lipoxygenase eicosanoids accelerates monocyte/endothelial interactions in diabetic db/db mice.5-Lipoxygenase, but not 12/15-lipoxygenase, contributes to degeneration of retinal capillaries in a mouse model of diabetic retinopathy.Eliminating or blocking 12/15-lipoxygenase reduces neutrophil recruitment in mouse models of acute lung injury12-Lipoxygenase Products Reduce Insulin Secretion and {beta}-Cell Viability in Human IsletsNonobese diabetic (NOD) mice congenic for a targeted deletion of 12/15-lipoxygenase are protected from autoimmune diabetesImproved survival and reduced vascular permeability by eliminating or blocking 12/15-lipoxygenase in mouse models of acute lung injury (ALI).The unique hypusine modification of eIF5A promotes islet beta cell inflammation and dysfunction in mice.12-Lipoxygenase-knockout mice are resistant to inflammatory effects of obesity induced by Western dietMechanisms by which diabetes increases cardiovascular disease.Role of uncoupling protein UCP2 in cell-mediated immunity: how macrophage-mediated insulitis is accelerated in a model of autoimmune diabetes.Baicalein Protects against Type 2 Diabetes via Promoting Islet β-Cell Function in Obese Diabetic Mice.Pathological aspects of lipid peroxidation.12-lipoxygenase promotes obesity-induced oxidative stress in pancreatic islets.Minireview: 12-Lipoxygenase and Islet β-Cell Dysfunction in Diabetes.Interactions of nitric oxide-derived reactive nitrogen species with peroxidases and lipoxygenases.Activated platelets and monocytes generate four hydroxyphosphatidylethanolamines via lipoxygenase.ALOX12 polymorphisms are associated with fat mass but not peak bone mineral density in Chinese nuclear families.High pancreatic n-3 fatty acids prevent STZ-induced diabetes in fat-1 mice: inflammatory pathway inhibitionElevated endothelial nitric oxide bioactivity and resistance to angiotensin-dependent hypertension in 12/15-lipoxygenase knockout mice.Eicosanoids, β-cell function, and diabetesEffect of gestational hypercholesterolemia and maternal immunization on offspring plasma eicosanoidsGroup VIA Phospholipase A2 (iPLA2β) Modulates Bcl-x 5'-Splice Site Selection and Suppresses Anti-apoptotic Bcl-x(L) in β-Cells.Islet complex lipids: involvement in the actions of group VIA calcium-independent phospholipase A(2) in beta-cellsMice lacking macrophage 12/15-lipoxygenase are resistant to experimental hypertension.Insulin secretory responses and phospholipid composition of pancreatic islets from mice that do not express Group VIA phospholipase A2 and effects of metabolic stress on glucose homeostasis.New families of bioactive oxidized phospholipids generated by immune cells: identification and signaling actions.Catalytic consumption of nitric oxide by 12/15- lipoxygenase: inhibition of monocyte soluble guanylate cyclase activationDisparate effects of 12-lipoxygenase and 12-hydroxyeicosatetraenoic acid in vascular endothelial and smooth muscle cells and in cardiomyocytes.Lipids and immunoinflammatory pathways of beta cell destruction.Inhibition of 12/15-lipoxygenase by baicalein induces microglia PPARβ/δ: a potential therapeutic role for CNS autoimmune disease.12-Lipoxygenase Inhibition on Microalbuminuria in Type-1 and Type-2 Diabetes Is Associated with Changes of Glomerular Angiotensin II Type 1 Receptor Related to Insulin Resistance.Apoptosis of insulin-secreting cells induced by endoplasmic reticulum stress is amplified by overexpression of group VIA calcium-independent phospholipase A2 (iPLA2 beta) and suppressed by inhibition of iPLA2 beta.Interaction between cytokines and inflammatory cells in islet dysfunction, insulin resistance and vascular diseaseMicroarray analysis of rat pancreas reveals altered expression of Alox15 and regenerating islet-derived genes in response to iron deficiency and overload.
P2860
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P2860
Resistance to type 1 diabetes induction in 12-lipoxygenase knockout mice.
description
1999 nî lūn-bûn
@nan
1999 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
name
Resistance to type 1 diabetes induction in 12-lipoxygenase knockout mice.
@ast
Resistance to type 1 diabetes induction in 12-lipoxygenase knockout mice.
@en
type
label
Resistance to type 1 diabetes induction in 12-lipoxygenase knockout mice.
@ast
Resistance to type 1 diabetes induction in 12-lipoxygenase knockout mice.
@en
prefLabel
Resistance to type 1 diabetes induction in 12-lipoxygenase knockout mice.
@ast
Resistance to type 1 diabetes induction in 12-lipoxygenase knockout mice.
@en
P2093
P2860
P356
P1476
Resistance to type 1 diabetes induction in 12-lipoxygenase knockout mice.
@en
P2093
P2860
P304
P356
10.1172/JCI5241
P407
P577
1999-05-01T00:00:00Z