Insulin secretory responses and phospholipid composition of pancreatic islets from mice that do not express Group VIA phospholipase A2 and effects of metabolic stress on glucose homeostasis.
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The role of peroxidation of mitochondrial membrane phospholipids in pancreatic β -cell failurePhospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic interventionMaintenance of synaptic stability requires calcium-independent phospholipase A₂ activityGenetic ablation of PLA2G6 in mice leads to cerebellar atrophy characterized by Purkinje cell loss and glial cell activationUnique membrane interaction mode of group IIF phospholipase A2Characterization of FKGK18 as inhibitor of group VIA Ca2+-independent phospholipase A2 (iPLA2β): candidate drug for preventing beta-cell apoptosis and diabetesCauses of early-onset type 1 diabetes: toward data-driven environmental approaches.Group VIA phospholipase A2 mitigates palmitate-induced β-cell mitochondrial injury and apoptosisGenetic ablation of calcium-independent phospholipase A2gamma prevents obesity and insulin resistance during high fat feeding by mitochondrial uncoupling and increased adipocyte fatty acid oxidation.Evidence for proteolytic processing and stimulated organelle redistribution of iPLA(2)beta.Group VIA Ca2+-independent phospholipase A2 (iPLA2beta) and its role in beta-cell programmed cell death.Mice deficient in group VIB phospholipase A2 (iPLA2gamma) exhibit relative resistance to obesity and metabolic abnormalities induced by a Western diet.Genetic ablation of calcium-independent phospholipase A(2)beta causes hypercontractility and markedly attenuates endothelium-dependent relaxation to acetylcholine.Protection of pancreatic beta-cells by group VIA phospholipase A(2)-mediated repair of mitochondrial membrane peroxidation.Group X secretory phospholipase A2 regulates insulin secretion through a cyclooxygenase-2-dependent mechanism.Global Inactivation of the Pla2g6 Gene in Mice Does Not Cause Dyslipidemia under Chow or High-fat Diet Conditions.Group VIA phospholipase A2 in both host and tumor cells is involved in ovarian cancer development.Platelet-activating factor and metastasis: calcium-independent phospholipase A2β deficiency protects against breast cancer metastasis to the lung.Lysophosphatidylcholine as an effector of fatty acid-induced insulin resistance.Inhibition of Ca2+-independent phospholipase A2β (iPLA2β) ameliorates islet infiltration and incidence of diabetes in NOD mice.Phospholipid hydrolysis and insulin secretion: a step toward solving the Rubik's cube.Analysis of two major intracellular phospholipases A(2) (PLA(2)) in mast cells reveals crucial contribution of cytosolic PLA(2)α, not Ca(2+)-independent PLA(2)β, to lipid mobilization in proximal mast cells and distal fibroblasts.Mitochondrial dysfunction and β-cell failure in type 2 diabetes mellitus.Group VIA PLA2 (iPLA2β) is activated upstream of p38 mitogen-activated protein kinase (MAPK) in pancreatic islet β-cell signalingBeta-Cell Injury in Ncb5or-null Mice is Exacerbated by Consumption of a High-Fat Diet.Calcium-independent phospholipases A2 and their roles in biological processes and diseases.Modulation of the pancreatic islet beta-cell-delayed rectifier potassium channel Kv2.1 by the polyunsaturated fatty acid arachidonate.Attenuated free cholesterol loading-induced apoptosis but preserved phospholipid composition of peritoneal macrophages from mice that do not express group VIA phospholipase A2.Group VIA phospholipase A2 (iPLA2beta) participates in angiotensin II-induced transcriptional up-regulation of regulator of g-protein signaling-2 in vascular smooth muscle cells.Deficiency of iPLA₂β Primes Immune Cells for Proinflammation: Potential Involvement in Age-Related Mesenteric Lymph Node LymphomaGlucose homeostasis, insulin secretion, and islet phospholipids in mice that overexpress iPLA2beta in pancreatic beta-cells and in iPLA2beta-null miceAge-related changes in bone morphology are accelerated in group VIA phospholipase A2 (iPLA2beta)-null miceDisrupted membrane homeostasis and accumulation of ubiquitinated proteins in a mouse model of infantile neuroaxonal dystrophy caused by PLA2G6 mutationsDiminished acyl-CoA synthetase isoform 4 activity in INS 832/13 cells reduces cellular epoxyeicosatrienoic acid levels and results in impaired glucose-stimulated insulin secretion.Role of calcium-independent phospholipase A(2)β in human pancreatic islet β-cell apoptosis.Skeletal muscle group VIA phospholipase A2 (iPLA2beta): expression and role in fatty acid oxidation.Phospholipase A2 structure/function, mechanism, and signaling.Localizing the membrane binding region of Group VIA Ca2+-independent phospholipase A2 using peptide amide hydrogen/deuterium exchange mass spectrometryDeletion of GPR40 impairs glucose-induced insulin secretion in vivo in mice without affecting intracellular fuel metabolism in islets.Establishment of an improved mouse model for infantile neuroaxonal dystrophy that shows early disease onset and bears a point mutation in Pla2g6.
P2860
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P2860
Insulin secretory responses and phospholipid composition of pancreatic islets from mice that do not express Group VIA phospholipase A2 and effects of metabolic stress on glucose homeostasis.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Insulin secretory responses an ...... stress on glucose homeostasis.
@ast
Insulin secretory responses an ...... stress on glucose homeostasis.
@en
type
label
Insulin secretory responses an ...... stress on glucose homeostasis.
@ast
Insulin secretory responses an ...... stress on glucose homeostasis.
@en
prefLabel
Insulin secretory responses an ...... stress on glucose homeostasis.
@ast
Insulin secretory responses an ...... stress on glucose homeostasis.
@en
P2093
P2860
P356
P1476
Insulin secretory responses an ...... stress on glucose homeostasis
@en
P2093
Alan Bohrer
Haowei Song
Mary Wohltmann
Sasanka Ramanadham
P2860
P304
20958-20973
P356
10.1074/JBC.M600075200
P407
P577
2006-05-27T00:00:00Z