Genetic evidence that the differential expression of the ligand-independent isoform of CTLA-4 is the molecular basis of the Idd5.1 type 1 diabetes region in nonobese diabetic mice.
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Regulatory T cell: a protection for tumour cellsCTLA-4 blockade in tumor models: an overview of preclinical and translational researchCellular mechanisms of restored β-cell tolerance mediated by protective alleles of Idd3 and Idd5Evidence that Cd101 is an autoimmune diabetes gene in nonobese diabetic miceA comprehensive genetic analysis of candidate genes regulating response to Trypanosoma congolense infection in mice.A novel pancreatic β-cell targeting bispecific-antibody (BsAb) can prevent the development of type 1 diabetes in NOD miceUse of nonobese diabetic mice to understand human type 1 diabetesDistinct genetic control of autoimmune neuropathy and diabetes in the non-obese diabetic background.A recombination hotspot leads to sequence variability within a novel gene (AK005651) and contributes to type 1 diabetes susceptibility64Cu-DOTA-anti-CTLA-4 mAb enabled PET visualization of CTLA-4 on the T-cell infiltrating tumor tissuesAn update on the use of NOD mice to study autoimmune (Type 1) diabetes.The B7-independent isoform of CTLA-4 functions to regulate autoimmune diabetesAn autoimmune-associated variant in PTPN2 reveals an impairment of IL-2R signaling in CD4(+) T cells.The soluble CTLA-4 splice variant protects from type 1 diabetes and potentiates regulatory T-cell functionBlockade of the programmed death-1 (PD1) pathway undermines potent genetic protection from type 1 diabetes.Overexpression of the Ctla-4 isoform lacking exons 2 and 3 causes autoimmunityPre-B cell leukemia homeobox 1 is associated with lupus susceptibility in mice and humans.Breakdown in peripheral tolerance in type 1 diabetes in mice and humansA transendocytosis model of CTLA-4 function predicts its suppressive behavior on regulatory T cells.The role of coinhibitory signaling pathways in transplantation and tolerancedNP2 is a blood-brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitisSubcongenic analyses reveal complex interactions between distal chromosome 4 genes controlling diabetogenic B cells and CD4 T cells in nonobese diabetic mice.Sleeping Beauty Transposon Mutagenesis as a Tool for Gene Discovery in the NOD Mouse Model of Type 1 DiabetesA SNP in the Immunoregulatory Molecule CTLA-4 Controls mRNA Splicing In Vivo but Does Not Alter Diabetes Susceptibility in the NOD MouseGenetic interactions among Idd3, Idd5.1, Idd5.2, and Idd5.3 protective loci in the nonobese diabetic mouse model of type 1 diabetes.Co-stimulatory and Co-inhibitory Pathways in Autoimmunity.Obstacles and opportunities for targeting the effector T cell response in type 1 diabetes.Coinhibitory Pathways in the B7-CD28 Ligand-Receptor Family.From markers to molecular mechanisms: type 1 diabetes in the post-GWAS era.Altered immune regulation in type 1 diabetes.Fine mapping of type 1 diabetes regions Idd9.1 and Idd9.2 reveals genetic complexity.Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease.Intrinsic and extrinsic control of peripheral T-cell tolerance by costimulatory molecules of the CD28/ B7 familyImmune checkpoints in central nervous system autoimmunity.Treg and CTLA-4: two intertwining pathways to immune tolerance.Understanding the CD28/CTLA-4 (CD152) pathway and its implications for costimulatory blockade.Restoring Regulatory T Cells in Type 1 Diabetes.Evidence for genes controlling resistance to Heligmosomoides bakeri on mouse chromosome 1.Congenic mice reveal genetic epistasis and overlapping disease loci for autoimmune diabetes and listeriosis.The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses.
P2860
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P2860
Genetic evidence that the differential expression of the ligand-independent isoform of CTLA-4 is the molecular basis of the Idd5.1 type 1 diabetes region in nonobese diabetic mice.
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2009 nî lūn-bûn
@nan
2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
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2009年学术文章
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2009年学术文章
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2009年学术文章
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2009年学术文章
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2009年学术文章
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2009年學術文章
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name
Genetic evidence that the diff ...... ion in nonobese diabetic mice.
@ast
Genetic evidence that the diff ...... ion in nonobese diabetic mice.
@en
type
label
Genetic evidence that the diff ...... ion in nonobese diabetic mice.
@ast
Genetic evidence that the diff ...... ion in nonobese diabetic mice.
@en
prefLabel
Genetic evidence that the diff ...... ion in nonobese diabetic mice.
@ast
Genetic evidence that the diff ...... ion in nonobese diabetic mice.
@en
P2093
P2860
P356
P1476
Genetic evidence that the diff ...... gion in nonobese diabetic mice
@en
P2093
Arlene H Sharpe
Daniel B Rainbow
Denise Chung
Giselle Chamberlain
Kara M D Hunter
Lalitha Vijayakrishnan
Laurence B Peterson
Linda S Wicker
Manabu Araki
Mohamed Oukka
P2860
P304
P356
10.4049/JIMMUNOL.0802610
P407
P50
P577
2009-09-25T00:00:00Z