Interactions of HIV-1 NEF with cellular signal transducing proteins.
about
HIV-1 Nef binds the DOCK2-ELMO1 complex to activate rac and inhibit lymphocyte chemotaxisMechanism for down-regulation of CD28 by Nef.Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neuronsConformation of the dileucine-based sorting motif in HIV-1 Nef revealed by intermolecular domain assemblyLentivirus Nef specifically activates Pak2.A hydrophobic binding surface on the human immunodeficiency virus type 1 Nef core is critical for association with p21-activated kinase 2.Interaction with the Src homology (SH3-SH2) region of the Src-family kinase Hck structures the HIV-1 Nef dimer for kinase activation and effector recruitmentThe accessory factor Nef links HIV-1 to Tec/Btk kinases in an Src homology 3 domain-dependent manner.HIV-1 Nef-mediated T-cell activation and chemotaxis are decoupled using a HIV-1/SIVpbj1.9. chimeric nef variant.HIV-1 Nef interaction influences the ATP-binding site of the Src-family kinase, HckStructure, dynamics, and Hck interaction of full-length HIV-1 Nef.Competitive displacement of full-length HIV-1 Nef from the Hck SH3 domain by a high-affinity artificial peptide.HIV-1 Nef selectively activates Src family kinases Hck, Lyn, and c-Src through direct SH3 domain interaction.Anti-CD45RO suppresses human immunodeficiency virus type 1 replication in microglia: role of Hck tyrosine kinase and implications for AIDS dementia.The pathogenicity of human immunodeficiency virus (HIV) type 1 Nef in CD4C/HIV transgenic mice is abolished by mutation of its SH3-binding domain, and disease development is delayed in the absence of Hck.Activation of NFAT-dependent gene expression by Nef: conservation among divergent Nef alleles, dependence on SH3 binding and membrane association, and cooperation with protein kinase C-thetaHuman T-lymphotropic virus type 1 open reading frame I p12(I) is required for efficient viral infectivity in primary lymphocytes.Design and use of an inducibly activated human immunodeficiency virus type 1 Nef to study immune modulation.Effector kinase coupling enables high-throughput screens for direct HIV-1 Nef antagonists with antiretroviral activity.Chemical library screens targeting an HIV-1 accessory factor/host cell kinase complex identify novel antiretroviral compoundsDevelopment and validation of a high-content bimolecular fluorescence complementation assay for small-molecule inhibitors of HIV-1 Nef dimerization.Single vector system for efficient N-myristoylation of recombinant proteins in E. coli.Conformational transition of membrane-associated terminally acylated HIV-1 Nef.HIV-1 Transmission, Replication Fitness and Disease Progression.Inhibition of human immunodeficiency virus type 1 by triciribine involves the accessory protein nefThe Nef-mediated AIDS-like disease of CD4C/human immunodeficiency virus transgenic mice is associated with increased Fas/FasL expression on T cells and T-cell death but is not prevented in Fas-, FasL-, tumor necrosis factor receptor 1-, or interleukExogenous Nef is an inhibitor of Mycobacterium tuberculosis-induced tumor necrosis factor-alpha production and macrophage apoptosis.Genetic and functional diversity of human immunodeficiency virus type 1 subtype B Nef primary isolatesHyperattenuated recombinant influenza A virus nonstructural-protein-encoding vectors induce human immunodeficiency virus type 1 Nef-specific systemic and mucosal immune responses in mice.Human immunodeficiency virus type 1 Nef functions at the level of virus entry by enhancing cytoplasmic delivery of virions.Restoration of wild-type infectivity to human immunodeficiency virus type 1 strains lacking nef by intravirion reverse transcription.Human immunodeficiency virus type 1 Nef selectively associates with a catalytically active subpopulation of p21-activated kinase 2 (PAK2) independently of PAK2 binding to Nck or beta-PIXNef alleles from all major HIV-1 clades activate Src-family kinases and enhance HIV-1 replication in an inhibitor-sensitive manner.Dynamic evolution of the human immunodeficiency virus type 1 pathogenic factor, Nef.Simian immunodeficiency virus Nef protein delays the progression of CD4+ T cells through G1/S phase of the cell cycle.Human T-cell lymphotropic virus type 1 p12(I) expression increases cytoplasmic calcium to enhance the activation of nuclear factor of activated T cells.Functional genomics in HIV-1 virus replication: protein-protein interactions as a basis for recruiting the host cell machinery for viral propagation.Vav proteins, adaptors and cell signaling.Nef proteins from simian immunodeficiency virus-infected chimpanzees interact with p21-activated kinase 2 and modulate cell surface expression of various human receptorsAt the crossroads of homoeostasis and disease: roles of the PACS proteins in membrane traffic and apoptosis.
P2860
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P2860
Interactions of HIV-1 NEF with cellular signal transducing proteins.
description
2000 nî lūn-bûn
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2000 թուականի Փետրուարին հրատարակուած գիտական յօդուած
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2000 թվականի փետրվարին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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name
Interactions of HIV-1 NEF with cellular signal transducing proteins.
@ast
Interactions of HIV-1 NEF with cellular signal transducing proteins.
@en
type
label
Interactions of HIV-1 NEF with cellular signal transducing proteins.
@ast
Interactions of HIV-1 NEF with cellular signal transducing proteins.
@en
prefLabel
Interactions of HIV-1 NEF with cellular signal transducing proteins.
@ast
Interactions of HIV-1 NEF with cellular signal transducing proteins.
@en
P356
P1476
Interactions of HIV-1 NEF with cellular signal transducing proteins.
@en
P2093
P304
P356
10.2741/RENKEMA
P577
2000-02-01T00:00:00Z