Discovery of brain-penetrant, orally bioavailable aminothienopyridazine inhibitors of tau aggregation.

Discovery of brain-penetrant, orally bioavailable aminothienopyridazine inhibitors of tau aggregation.

Item
http://www.wikidata.org/entity/Q33861802
Phosphoprotein phosphatase 2A: a novel druggable target for Alzheimer's diseaseDeveloping therapeutic approaches to tau, selected kinases, and related neuronal protein targetsReducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathiesEpothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy.Aminothienopyridazine inhibitors of tau aggregation: evaluation of structure-activity relationship leads to selection of candidates with desirable in vivo properties.Advances in tau-based drug discovery.Aminothienopyridazines and methylene blue affect Tau fibrillization via cysteine oxidation.A model for improving the treatment and care of Alzheimer's disease patients through interdisciplinary research.Inhibition of Both Hsp70 Activity and Tau Aggregation in Vitro Best Predicts Tau Lowering Activity of Small Molecules.Modulation of protein-protein interactions as a therapeutic strategy for the treatment of neurodegenerative tauopathies.The role of FKBP5 in mood disorders: action of FKBP5 on steroid hormone receptors leads to questions about its evolutionary importance.Aminothienopyridazines as imaging probes of tau pathology: a patent evaluation of WO2013090497.Inhibition of JNK by a peptide inhibitor reduces traumatic brain injury-induced tauopathy in transgenic miceCountering amyloid polymorphism and drug resistance with minimal drug cocktails.Structure-activity relationship of cyclic thiacarbocyanine tau aggregation inhibitors.Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau.Combination of PKCε Activation and PTP1B Inhibition Effectively Suppresses Aβ-Induced GSK-3β Activation and Tau Phosphorylation.
P2860

Discovery of brain-penetrant, orally bioavailable aminothienopyridazine inhibitors of tau aggregation.

Item
http://www.wikidata.org/entity/Q33861802
description
2010 nî lūn-bûn
@nan
2010 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Discovery of brain-penetrant, ...... inhibitors of tau aggregation.
@ast
Discovery of brain-penetrant, ...... inhibitors of tau aggregation.
@en
type
label
Discovery of brain-penetrant, ...... inhibitors of tau aggregation.
@ast
Discovery of brain-penetrant, ...... inhibitors of tau aggregation.
@en
prefLabel
Discovery of brain-penetrant, ...... inhibitors of tau aggregation.
@ast
Discovery of brain-penetrant, ...... inhibitors of tau aggregation.
@en
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698
P932
P356
P1433
P1476
Discovery of brain-penetrant, ...... inhibitors of tau aggregation.
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698
P932