CDK/CK1 inhibitors roscovitine and CR8 downregulate amplified MYCN in neuroblastoma cells. - Wikidata - wikimedia - TriplyDB

CDK/CK1 inhibitors roscovitine and CR8 downregulate amplified MYCN in neuroblastoma cells.

CDK/CK1 inhibitors roscovitine and CR8 downregulate amplified MYCN in neuroblastoma cells.

http://www.wikidata.org/entity/Q33864755

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Exploitation of the Apoptosis-Primed State of MYCN-Amplified Neuroblastoma to Develop a Potent and Specific Targeted Therapy Combination Hemisphere Asymmetry of Response to Pharmacologic Treatment in an Alzheimer's Disease Mouse Model Harnessing Neutrophil Survival Mechanisms during Chronic Infection by Pseudomonas aeruginosa: Novel Therapeutic Targets to Dampen Inflammation in Cystic Fibrosis Phosphoproteome Analysis Reveals Differential Mode of Action of Sorafenib in Wildtype and Mutated FLT3 Acute Myeloid Leukemia (AML) Cells CDK9 inhibitor FIT-039 prevents replication of multiple DNA viruses.Cyclin-Dependent Kinase Inhibitor AT7519 as a Potential Drug for MYCN-Dependent Neuroblastoma Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis.Hypothalamus proteomics from mouse models with obesity and anorexia reveals therapeutic targets of appetite regulation.Inhibition of endothelial Cdk5 reduces tumor growth by promoting non-productive angiogenesis.Multiple CDK inhibitor dinaciclib suppresses neuroblastoma growth via inhibiting CDK2 and CDK9 activity Potential Clinical Uses of CDK Inhibitors: Lessons from Synthetic Lethality Screens.Casein kinases as potential therapeutic targets.Combination of PIM and JAK2 inhibitors synergistically suppresses MPN cell proliferation and overcomes drug resistance.Structural basis of valmerins as dual inhibitors of GSK3β/CDK5.Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing.Antitumoral effects of cyclin-dependent kinases inhibitors CR8 and MR4 on chronic myeloid leukemia cell lines Detection of candidate biomarkers of prostate cancer progression in serum: a depletion-free 3D LC/MS quantitative proteomics pilot study.Systems proteomic analysis reveals that clusterin and tissue inhibitor of metalloproteinases 3 increase in leptomeningeal arteries affected by cerebral amyloid angiopathy.Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor.Casein kinase 1ε and 1α as novel players in polycystic kidney disease and mechanistic targets for (R)-roscovitine and (S)-CR8.Genetic and pharmacological inhibition of Cdk1 provides neuroprotection towards ischemic neuronal death.The effect of circadian rhythm on pharmacokinetics and metabolism of the Cdk inhibitor, roscovitine, in tumor mice model.MCL-1 inhibition in cancer treatment Dual BRD4 and AURKA Inhibition Is Synergistic against MYCN-Amplified and Nonamplified Neuroblastoma

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P2860

CDK/CK1 inhibitors roscovitine and CR8 downregulate amplified MYCN in neuroblastoma cells.

http://www.wikidata.org/entity/Q33864755

description

2013 nî lūn-bûn

@nan

2013 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

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2013 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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CDK/CK1 inhibitors roscovitine ...... d MYCN in neuroblastoma cells.

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CDK/CK1 inhibitors roscovitine ...... d MYCN in neuroblastoma cells.

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P2860

The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes

Interaction of cyclin-dependent kinase 12/CrkRS with cyclin K1 is required for the phosphorylation of the C-terminal domain of RNA polymerase II

Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma

On the origins of enzyme inhibitor selectivity and promiscuity: a case study of protein kinase binding to staurosporine

The selectivity of protein kinase inhibitors: a further update

Identification of ALK as a major familial neuroblastoma predisposition gene

CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases

N-&-N, a new class of cell death-inducing kinase inhibitors derived from the purine roscovitine

CDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma Cells

The CDK9 Tail Determines the Reaction Pathway of Positive Transcription Elongation Factor b

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