Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells - Wikidata - wikimedia - TriplyDB

Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells

Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells

http://www.wikidata.org/entity/Q33868788

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Approaches of targeting Rho GTPases in cancer drug discovery The role of p21-activated kinases in hepatocellular carcinoma metastasis FRAX597, a Small Molecule Inhibitor of the p21-activated Kinases, Inhibits Tumorigenesis of Neurofibromatosis Type 2 (NF2)-associated Schwannomas BRAF activates and physically interacts with PAK to regulate cell motility Small molecule inhibition of group I p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agents.p21-Activated kinase inhibitors: a patent review Molecular pathways: targeting p21-activated kinase 1 signaling in cancer--opportunities, challenges, and limitations PAK1 kinase promotes cell motility and invasiveness through CRK-II serine phosphorylation in non-small cell lung cancer cells PAK signalling during the development and progression of cancer Transcriptional regulation of fibronectin by p21-activated kinase-1 modulates pancreatic tumorigenesis Group I PAK inhibitor IPA-3 induces cell death and affects cell adhesivity to fibronectin in human hematopoietic cells Reduced PAK1 activity sensitizes FA/BRCA-proficient breast cancer cells to PARP inhibition Integrin-binding protein nischarin interacts with tumor suppressor liver kinase B1 (LKB1) to regulate cell migration of breast epithelial cells.Reconstructing targetable pathways in lung cancer by integrating diverse omics data Rate-Determining and Rate-Limiting Steps in the Clearance and Excretion of a Potent and Selective p21-Activated Kinase Inhibitor: A Case Study of Rapid Hepatic Uptake and Slow Elimination in Rat.Overexpression of PAK1 Correlates with Aberrant Expression of EMT Markers and Poor Prognosis in Non-Small Cell Lung Cancer.PKN1 modulates TGFβ and EGF signaling in HEC-1-A endometrial cancer cell line.Expression and significance of Rac1, Pak1 and Rock1 in gastric carcinoma.Development of p21 activated kinase-targeted multikinase inhibitors that inhibit thyroid cancer cell migration.Proapoptotic and antiinvasive activity of Rac1 small molecule inhibitors on malignant glioma cells Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK a Polar Moiety.PAK1 mediates resistance to PI3K inhibition in lymphomas.Reduced expression of p21-activated protein kinase 1 correlates with poor histological differentiation in pancreatic cancer.Prognostic importance and therapeutic implications of PAK1, a drugable protein kinase, in gastroesophageal junction adenocarcinoma.Label-free morphology-based prediction of multiple differentiation potentials of human mesenchymal stem cells for early evaluation of intact cells.Group I Paks as therapeutic targets in NF2-deficient meningioma.P-REX1 creates a positive feedback loop to activate growth factor receptor, PI3K/AKT and MEK/ERK signaling in breast cancer.HOXA5 inhibits metastasis via regulating cytoskeletal remodelling and associates with prolonged survival in non-small-cell lung carcinoma miR-155 Controls Lymphoproliferation in LAT Mutant Mice by Restraining T-Cell Apoptosis via SHIP-1/mTOR and PAK1/FOXO3/BIM Pathways p21-Activated Kinases 1, 2 and 4 in Endometrial Cancers: Effects on Clinical Outcomes and Cell Proliferation.Dysregulation of PAK1 Is Associated with DNA Damage and Is of Prognostic Importance in Primary Esophageal Small Cell Carcinoma.Inhibition or ablation of p21-activated kinase (PAK1) disrupts glucose homeostatic mechanisms in vivo.p21-Activated Kinase 4 (PAK4) as a Predictive Marker of Gemcitabine Sensitivity in Pancreatic Cancer Cell Lines.PAK1 is a therapeutic target in acute myeloid leukemia and myelodysplastic syndrome.Kinase-independent role for CRAF-driving tumour radioresistance via CHK2 Potential role of p21 Activated Kinase 1 (PAK1) in the invasion and motility of oral cancer cells.Tyrosyl phosphorylated serine-threonine kinase PAK1 is a novel regulator of prolactin-dependent breast cancer cell motility and invasion.The Group I Pak inhibitor Frax-1036 sensitizes 11q13-amplified ovarian cancer cells to the cytotoxic effects of Rottlerin.Pak1/LIMK1/Cofilin Pathway Contributes to Tumor Migration and Invasion in Human Non-Small Cell Lung Carcinomas and Cell Lines.p21-activated kinase 1 determines stem-like phenotype and sunitinib resistance via NF-κB/IL-6 activation in renal cell carcinoma.

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Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells

http://www.wikidata.org/entity/Q33868788

description

2011 nî lūn-bûn

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2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի ապրիլին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

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2011年论文

@wuu

name

Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells

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Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells

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type

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Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells

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Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells

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prefLabel

Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells

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Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells

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PNAS.1103350108

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Proceedings of the National Academy of Sciences of the United States of America

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Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells

@en

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Adrian M Jubb

http://www.w3.org/2001/XMLSchema#string

Christy C Ong

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Domagoj Vucic

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Elizabeth M Blackwood

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Hartmut Koeppen

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Helen Turley

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Klaus P Hoeflich

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Lori S Friedman

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Marcia Belvin

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Peter M Haverty

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P2860

IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer

IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis

Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells

E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints

Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth

p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis

p21-activated kinase-1 signaling mediates cyclin D1 expression in mammary epithelial and cancer cells

p21-activated kinases in cancer

An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase

MicroRNA-7, a homeobox D10 target, inhibits p21-activated kinase 1 and regulates its functions

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7177-7182

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10.1073/PNAS.1103350108

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17

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108

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Adrian L Harris

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2011-04-11T00:00:00Z

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51041581

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21482786

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3084065

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