In vivo pH in metabolic-defective Ras-transformed fibroblast tumors: key role of the monocarboxylate transporter, MCT4, for inducing an alkaline intracellular pH.
about
Radiosynthesis and validation of (±)-[18F]-3-fluoro-2-hydroxypropionate ([18F]-FLac) as a PET tracer of lactate to monitor MCT1-dependent lactate uptake in tumorsAnticancer targets in the glycolytic metabolism of tumors: a comprehensive reviewThe human proton-coupled folate transporter: Biology and therapeutic applications to cancer.Identification of key binding site residues of MCT1 for AR-C155858 reveals the molecular basis of its isoform selectivity.CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors.High-field small animal magnetic resonance oncology studies.AMP-activated protein kinase is dispensable for maintaining ATP levels and for survival following inhibition of glycolysis, but promotes tumour engraftment of Ras-transformed fibroblasts.Lactate promotes PGE2 synthesis and gluconeogenesis in monocytes to benefit the growth of inflammation-associated colorectal tumor.Knock out of the BASIGIN/CD147 chaperone of lactate/H+ symporters disproves its pro-tumour action via extracellular matrix metalloproteases (MMPs) induction.Roles of acid-extruding ion transporters in regulation of breast cancer cell growth in a 3-dimensional microenvironment.Monocarboxylate transporters in the brain and in cancer.Lactate/pyruvate transporter MCT-1 is a direct Wnt target that confers sensitivity to 3-bromopyruvate in colon cancer.Inside out: targeting NHE1 as an intracellular and extracellular regulator of cancer progression.Monocarboxylic acid transport.Role of pHi, and proton transporters in oncogene-driven neoplastic transformation.Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium.Acid-base transport in pancreatic cancer: molecular mechanisms and clinical potential.Pyruvate cellular uptake and enzymatic conversion probed by dissolution DNP-NMR: the impact of overexpressed membrane transporters.Hypoxia and cellular metabolism in tumour pathophysiology.In vitro expansion of U87-MG human glioblastoma cells under hypoxic conditions affects glucose metabolism and subsequent in vivo growth.The Role of pH Regulation in Cancer Progression.Effects of metabolic acidosis on intracellular pH responses in multiple cell typesCancer cell behaviors mediated by dysregulated pH dynamics at a glance.Inhibition of monocarboxylate transporter-4 depletes stem-like glioblastoma cells and inhibits HIF transcriptional response in a lactate-independent manner.Hypoxia promotes tumor cell survival in acidic conditions by preserving ATP levels.Physical and Chemical Gradients in the Tumor Microenvironment Regulate Tumor Cell Invasion, Migration, and Metastasis.Genome-wide RNA interference analysis of renal carcinoma survival regulators identifies MCT4 as a Warburg effect metabolic targetNormoxic accumulation of HIF1α is associated with glutaminolysis.The real face of HIF1α in the tumor process.Intracellular pH measured by 31 P-MR-spectroscopy might predict site of progression in recurrent glioblastoma under antiangiogenic therapy.DNA hypermethylation and 1p Loss silence NHE-1 in oligodendroglioma.Integration of a 'proton antenna' facilitates transport activity of the monocarboxylate transporter MCT4.Functional screening identifies MCT4 as a key regulator of breast cancer cell metabolism and survival.Development and validation of chemical features-based proton-coupled folate transporter/activity and reduced folate carrier/activity models (pharmacophores).HRG-1 enhances cancer cell invasive potential and couples glucose metabolism to cytosolic/extracellular pH gradient regulation by the vacuolar-H(+) ATPase.Disrupting Na⁺, HCO₃⁻-cotransporter NBCn1 (Slc4a7) delays murine breast cancer development.Na+,HCO3- -cotransport is functionally upregulated during human breast carcinogenesis and required for the inverted pH gradient across the plasma membrane.
P2860
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P2860
In vivo pH in metabolic-defective Ras-transformed fibroblast tumors: key role of the monocarboxylate transporter, MCT4, for inducing an alkaline intracellular pH.
description
2011 nî lūn-bûn
@nan
2011 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
In vivo pH in metabolic-defect ...... an alkaline intracellular pH.
@ast
In vivo pH in metabolic-defect ...... an alkaline intracellular pH.
@en
type
label
In vivo pH in metabolic-defect ...... an alkaline intracellular pH.
@ast
In vivo pH in metabolic-defect ...... an alkaline intracellular pH.
@en
prefLabel
In vivo pH in metabolic-defect ...... an alkaline intracellular pH.
@ast
In vivo pH in metabolic-defect ...... an alkaline intracellular pH.
@en
P2093
P2860
P356
P1476
In vivo pH in metabolic-defect ...... an alkaline intracellular pH.
@en
P2093
Christophe Vilmen
Frédéric Frassineti
Johanna Chiche
Laurent Daniel
Norbert W Lutz
Patrick J Cozzone
Yann Le Fur
P2860
P304
P356
10.1002/IJC.26125
P577
2011-05-30T00:00:00Z