CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors. - Wikidata - wikimedia - TriplyDB

CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors.

CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors.

http://www.wikidata.org/entity/Q35289071

about

Novel drugs that target the metabolic reprogramming in renal cell cancer Overcoming Hypoxia-Mediated Tumor Progression: Combinatorial Approaches Targeting pH Regulation, Angiogenesis and Immune Dysfunction Basigin (CD147), a multifunctional transmembrane glycoprotein with various binding partners How, with whom and when: an overview of CD147-mediated regulatory networks influencing matrix metalloproteinase activity Metabolic reprogramming and metabolic dependency in T cells Alternative fuels for cancer cells SLC transporters as therapeutic targets: emerging opportunities The altered glucose metabolism in tumor and a tumor acidic microenvironment associated with extracellular matrix metalloproteinase inducer and monocarboxylate transporters Reprogramming of glucose metabolism in hepatocellular carcinoma: Progress and prospects Reexamining cancer metabolism: Lactate production for carcinogenesis could be the purpose and explanation of the Warburg effect Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H(+) symporters Integrated proteomic and metabolic analysis of breast cancer progression New aspects of an old drug--diclofenac targets MYC and glucose metabolism in tumor cells Crucial residue involved in L-lactate recognition by human monocarboxylate transporter 4 (hMCT4)Cancer: fundamentals behind pH targeting and the double-edged approach Radiosynthesis and validation of (±)-[18F]-3-fluoro-2-hydroxypropionate ([18F]-FLac) as a PET tracer of lactate to monitor MCT1-dependent lactate uptake in tumors Disruption of the monocarboxylate transporter-4-basigin interaction inhibits the hypoxic response, proliferation, and tumor progression.Rapid uptake of glucose and lactate, and not hypoxia, induces apoptosis in three-dimensional tumor tissue culture CD147 required for corneal endothelial lactate transport.Transcriptional profiling of formalin fixed paraffin embedded tissue: pitfalls and recommendations for identifying biologically relevant changes.Transcriptome analysis of the spalax hypoxia survival response includes suppression of apoptosis and tight control of angiogenesis.The biological function and clinical utilization of CD147 in human diseases: a review of the current scientific literature 3-bromopyruvate enhanced daunorubicin-induced cytotoxicity involved in monocarboxylate transporter 1 in breast cancer cells Attacking the supply wagons to starve cancer cells to death.Inhibition of monocarboxylate transporter-1 (MCT1) by AZD3965 enhances radiosensitivity by reducing lactate transport.A role for the mitochondrial pyruvate carrier as a repressor of the Warburg effect and colon cancer cell growth The monocarboxylate transporter 4 is required for glycolytic reprogramming and inflammatory response in macrophages.CD147 modulates autophagy through the PI3K/Akt/mTOR pathway in human prostate cancer PC-3 cells.Identification of key binding site residues of MCT1 for AR-C155858 reveals the molecular basis of its isoform selectivity.SIRT3 Enhances Glycolysis and Proliferation in SIRT3-Expressing Gastric Cancer Cells.Disruption of BASIGIN decreases lactic acid export and sensitizes non-small cell lung cancer to biguanides independently of the LKB1 status Fasting induces anti-Warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models.AMP-activated protein kinase is dispensable for maintaining ATP levels and for survival following inhibition of glycolysis, but promotes tumour engraftment of Ras-transformed fibroblasts.Hypoxia-induced carbonic anhydrase IX facilitates lactate flux in human breast cancer cells by non-catalytic function.Significance of glycolytic metabolism-related protein expression in colorectal cancer, lymph node and hepatic metastasis.Human tumor cells induce angiogenesis through positive feedback between CD147 and insulin-like growth factor-I.Amniotic membrane traps and induces apoptosis of inflammatory cells in ocular surface chemical burn.Targeting lactate transport suppresses in vivo breast tumour growth Mathematical modeling of acid-base physiology.Knock out of the BASIGIN/CD147 chaperone of lactate/H+ symporters disproves its pro-tumour action via extracellular matrix metalloproteases (MMPs) induction.

P2860

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P2860

CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors.

http://www.wikidata.org/entity/Q35289071

description

2011 nî lūn-bûn

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2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

CD147 subunit of lactate/H+ sy ...... d growth of glycolytic tumors.

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CD147 subunit of lactate/H+ sy ...... d growth of glycolytic tumors.

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type

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CD147 subunit of lactate/H+ sy ...... d growth of glycolytic tumors.

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CD147 subunit of lactate/H+ sy ...... d growth of glycolytic tumors.

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CD147 subunit of lactate/H+ sy ...... d growth of glycolytic tumors.

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CD147 subunit of lactate/H+ sy ...... d growth of glycolytic tumors.

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PNAS.1106123108

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Proceedings of the National Academy of Sciences of the United States of America

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CD147 subunit of lactate/H+ sy ...... d growth of glycolytic tumors.

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Danièle Roux

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Ibtissam Marchiq

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Johanna Chiche

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Karine Ilc

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Marie-Pierre Simon

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Renaud Le Floch

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Susan E Critchlow

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Tanesha Naiken

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P2860

Understanding the Warburg effect: the metabolic requirements of cell proliferation

CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression

HIF-1: upstream and downstream of cancer metabolism

Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle

Epithelial-mesenchymal transitions in development and disease

The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily

Studies on the DIDS-binding site of monocarboxylate transporter 1 suggest a homology model of the open conformation and a plausible translocation cycle

AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10

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40

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108

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Jacques Pouysségur

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2011-09-19T00:00:00Z

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51655151

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21930917

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