G-quadruplex DNA: a potential target for anti-cancer drug design.
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Human premature aging, DNA repair and RecQ helicasesDNA and the chromosome - varied targets for chemotherapyNot so crystal clear: the structure of the human telomere G-quadruplex in solution differs from that present in a crystalThe effect of osmolytes and small molecule on Quadruplex-WC duplex equilibrium: a fluorescence resonance energy transfer study.Supramolecular coordination: self-assembly of finite two- and three-dimensional ensemblesIn vitro generated antibodies specific for telomeric guanine-quadruplex DNA react with Stylonychia lemnae macronucleiStructure and stability of human telomeric G-quadruplex with preclinical 9-amino acridinesRecQ helicases: caretakers of the genomeEthidium derivatives bind to G-quartets, inhibit telomerase and act as fluorescent probes for quadruplexesCrystallization and characterization of the thallium form of the Oxytricha nova G-quadruplexTelomerase inhibitors based on quadruplex ligands selected by a fluorescence assay.Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effectPutative DNA G-quadruplex formation within the promoters of Plasmodium falciparum var genes.Molecular models for intrastrand DNA G-quadruplexes.2-aminopurine as a probe for quadruplex loop structures.Molecular crowding creates an essential environment for the formation of stable G-quadruplexes in long double-stranded DNAMacrocyclic pyridyl polyoxazoles: selective RNA and DNA G-quadruplex ligands as antitumor agents.Cyclo[n]pyrroles: size and site-specific binding to G-quadruplexes.Cell senescence and telomere shortening induced by a new series of specific G-quadruplex DNA ligands.Molecular dynamics of anthraquinone DNA intercalators with polyethylene glycol side chains.The formation and stabilization of a novel G-quadruplex in the 5'-flanking region of the relaxin gene.Formation pathways of a guanine-quadruplex DNA revealed by molecular dynamics and thermodynamic analysis of the substates.Telomere maintenance mechanisms as a target for drug development.Design, synthesis and biological evaluation of a novel class of anticancer agents: anthracenylisoxazole lexitropsin conjugatesPolycyclic azoniahetarenes: assessing the binding parameters of complexes between unsubstituted ligands and G-quadruplex DNA.Therapeutic strategies to inhibit MYCQuadruplex structures in nucleic acids.G-quadruplexes as therapeutic targets.Telomerase inhibitors for the treatment of cancer: the current perspective.Interactions of actinomycin D with human telomeric G-quadruplex DNA.Beyond nucleic acid base pairs: from triads to heptads.hnRNP A1 associates with telomere ends and stimulates telomerase activityA G-quadruplex DNA-based, label-free and ultrasensitive strategy for microRNA detectionTelomere maintenance as a target for anticancer drug discovery.Assessing the amount of quadruplex structures present within G₂-tract synthetic random-sequence DNA librariesExplaining the varied glycosidic conformational, G-tract length and sequence preferences for anti-parallel G-quadruplexesDetection of G-quadruplex DNA using primer extension as a toolAptamers for pharmaceuticals and their application in environmental analytics.Defining the mode, energetics and specificity with which a macrocyclic hexaoxazole binds to human telomeric G-quadruplex DNAKinetics and mechanism of G-quadruplex formation and conformational switch in a G-quadruplex of PS2.M induced by Pb²⁺
P2860
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P2860
G-quadruplex DNA: a potential target for anti-cancer drug design.
description
2000 nî lūn-bûn
@nan
2000 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2000 թվականի ապրիլին հրատարակված գիտական հոդված
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2000年の論文
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2000年学术文章
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2000年学术文章
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2000年学术文章
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2000年学术文章
@zh-my
2000年学术文章
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2000年學術文章
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name
G-quadruplex DNA: a potential target for anti-cancer drug design.
@ast
G-quadruplex DNA: a potential target for anti-cancer drug design.
@en
type
label
G-quadruplex DNA: a potential target for anti-cancer drug design.
@ast
G-quadruplex DNA: a potential target for anti-cancer drug design.
@en
prefLabel
G-quadruplex DNA: a potential target for anti-cancer drug design.
@ast
G-quadruplex DNA: a potential target for anti-cancer drug design.
@en
P1476
G-quadruplex DNA: a potential target for anti-cancer drug design.
@en
P304
P356
10.1016/S0165-6147(00)01457-7
P577
2000-04-01T00:00:00Z