Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect
about
PML is required for telomere stability in non-neoplastic human cellsStabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway.Targeting glioma stem cells in vivo by a G-quadruplex-stabilizing synthetic macrocyclic hexaoxazole.Chemistry in human telomere biology: structure, function and targeting of telomere DNA/RNA.Bis-indole derivatives with antitumor activity turn out to be specific ligands of human telomeric G-quadruplexAn integrative biological approach to the analysis of tissue culture data: application to the antitumour agent RHPS4.Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?Identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activitiesRHPS4 G-quadruplex ligand induces anti-proliferative effects in brain tumor cells.Advances in the molecular design of potential anticancer agents via targeting of human telomeric DNA.A small molecule inhibitor of Pot1 binding to telomeric DNA.Aromatic core extension in the series of N-cyclic bay-substituted perylene G-quadruplex ligands: increased telomere damage, antitumor activity, and strong selectivity for neoplastic over healthy cells.Lead Exposure Induces Telomere Instability in Human CellsIdentification of new natural DNA G-quadruplex binders selected by a structure-based virtual screening approach.A basal level of DNA damage and telomere deprotection increases the sensitivity of cancer cells to G-quadruplex interactive compounds.Elevated levels of G-quadruplex formation in human stomach and liver cancer tissues.G-quadruplexes: from guanine gels to chemotherapeuticsThe topoisomerase II catalytic inhibitor ICRF-193 preferentially targets telomeres that are capped by TRF2.The nickel(II) complex of guanidinium phenyl porphyrin, a specific G-quadruplex ligand, targets telomeres and leads to POT1 mislocalization in culture cells.A G-quadruplex-binding compound showing anti-tumour activity in an in vivo model for pancreatic cancerTelomerase and its potential for therapeutic intervention.Induction of senescence in cancer cells by the G-quadruplex stabilizer, BMVC4, is independent of its telomerase inhibitory activityG4LDB: a database for discovering and studying G-quadruplex ligands.Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds.Mechanism of the antiproliferative activity of some naphthalene diimide G-quadruplex ligands.Telomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanism.Intragenic G-quadruplex structure formed in the human CD133 and its biological and translational relevanceOne identity or more for telomeres?DNA damage signaling induced by the G-quadruplex ligand 12459 is modulated by PPM1D/WIP1 phosphatase.Development of an Optimized Protocol for NMR Metabolomics Studies of Human Colon Cancer Cell Lines and First Insight from Testing of the Protocol Using DNA G-Quadruplex Ligands as Novel Anti-Cancer Drugs.Mix and measure fluorescence screening for selective quadruplex binders.A hitchhiker's guide to G-quadruplex ligands.Acacetin and chrysin, two polyphenolic compounds, alleviate telomeric position effect in human cells.Telomere dysfunction and tumour suppression: the senescence connectionMammalian telomeres resemble fragile sites and require TRF1 for efficient replication.On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium saltsEvidence for G-quadruplex in the promoter of vegfr-2 and its targeting to inhibit tumor angiogenesis.Structural identity of telomeric complexes.Dynamics of telomeric chromatin at the crossroads of aging and cancer.Telomere replication: poised but puzzling
P2860
Q27309962-E1FA8FA7-C662-4821-9ED8-AE056A9379C8Q33481554-CCBD515E-6D78-4D39-A437-AE39E73F6A4EQ33804001-7AE80053-164B-43A1-90BA-DED923FE4DDCQ33814333-5E26440F-337A-4CFF-A851-73552134E5C4Q33944520-880832A0-410B-4D4B-B48F-EC951A0C075FQ33966047-7EABF03B-8D4F-4708-90C0-BC5C86BCE096Q34174883-E5B0553E-A3E9-4469-B032-496742EBA869Q34324128-6127C6FF-CDF5-4BE9-B779-6C1DC2295F16Q34399645-60FAB46F-DB5D-485E-B161-77F807732910Q34413414-95CD3174-61EB-4597-9D4B-7AA39CDC6BFFQ34414940-555075E6-6161-41AF-8502-755BEE07984CQ34457644-B511A957-2B95-45C2-97E1-57C58D712DA0Q34807536-0442E7F1-9E1A-44DC-A830-D507E11FB4B9Q35003819-D09C933D-9694-4C61-B00B-28E804452A28Q35089022-EB11A32A-C292-461F-954D-DB51A466EC50Q35208225-EA7046C3-E4E2-4D4A-94E6-98E7A283C5F1Q35211323-39188883-EC86-43CE-B1FE-F9D1B5A4D554Q35527683-FD8ADCA7-F4B0-4FD1-AA35-2847735DBA2CQ35595663-CBEC20EC-E30D-449E-9DBE-6A3F884C1703Q35745690-B0F43754-9C61-486B-BAC9-7D8DEA1D44B1Q36171337-3227EC52-C555-436F-A4E4-92E015A282A8Q36346931-E1721553-2EFE-4D97-A82C-F10E9A9A51A9Q36491171-42258857-5AF9-41D5-BB45-35AA4AB9262BQ36563979-B5A9F1BC-18A4-4AA6-8C69-F72A2820519EQ36573175-B6805249-E2A8-4E16-B16A-CC025405423EQ36610311-8CFCE158-70E6-4FEA-BF8C-E828BB254D01Q36627895-59196DBD-81B3-4A61-91DD-E29A3C77015AQ36687097-A5205741-9569-4E4C-8A5E-D25561D2EC3BQ36740850-FF1832D2-430A-4B4C-8109-4324A424C7DCQ36741609-A16C9633-6EF3-4EA5-81B7-74A13B13D2DAQ36909349-088CCF0A-B8BA-4B3C-B391-EB0EF475B6DEQ37080928-793066A2-AFF9-4E9B-B9A4-7B717E2DD0B1Q37138708-7219EC13-69A8-46F3-930A-E95329069D70Q37171810-7F7F1C5A-E894-463C-B7B9-84091AD83222Q37297007-8BB58050-4CD4-4595-B70B-FAED4CF59417Q37360409-B8832A89-937F-4C61-A5DE-31A1397213A2Q37631817-7D940448-63D2-4335-87A4-FF2A1119CF6DQ37778877-0B646F6A-130D-49F1-9F9F-ACE6B5A58346Q37785995-17376D65-2F91-4C13-ABAC-0FF3070AA6DFQ37814480-1A2010A3-0C9E-4738-A239-185CD474AEBF
P2860
Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect
description
2007 nî lūn-bûn
@nan
2007 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect
@ast
Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect
@en
Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect.
@nl
type
label
Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect
@ast
Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect
@en
Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect.
@nl
prefLabel
Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect
@ast
Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect
@en
Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect.
@nl
P2093
P2860
P50
P356
P1476
Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect
@en
P2093
Béatrice Horard
Eric Gilson
Gabriella Zupi
Malcolm F G Stevens
Marcella Mottolese
Marco Scarsella
Maria Blasco
Serge Bauwens
P2860
P304
P356
10.1172/JCI32461
P407
P50
P577
2007-11-01T00:00:00Z