Molecular structure of a major insulin/mitogen-activated 70-kDa S6 protein kinase.
about
Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich regionCloning and characterization of RLPK, a novel RSK-related protein kinaseHuman rsk isoforms: cloning and characterization of tissue-specific expressionCloning and expression of two human p70 S6 kinase polypeptides differing only at their amino terminiNuclear localization and regulation of erk- and rsk-encoded protein kinasesThe expanding role of mTOR in cancer cell growth and proliferationDistinct regulatory mechanism for p70 S6 kinase beta from that for p70 S6 kinase alphaSyk is required for BCR-mediated activation of p90Rsk, but not p70S6k, via a mitogen-activated protein kinase-independent pathway in B cellsIdentification of phosphorylation sites in the translational regulator, PHAS-I, that are controlled by insulin and rapamycin in rat adipocytesCloning and expression of cDNA encoding protein synthesis elongation factor-2 kinaseAmino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanismTOR signaling.A single gene encodes two isoforms of the p70 S6 kinase: activation upon mitogenic stimulation.Insulin promotes rat retinal neuronal cell survival in a p70S6K-dependent manner.Cross-talk between sirtuin and mammalian target of rapamycin complex 1 (mTORC1) signaling in the regulation of S6 kinase 1 (S6K1) phosphorylation.Structural and functional analysis of pp70S6k.mTORC1 and JNK coordinate phosphorylation of the p70S6K1 autoinhibitory domain in skeletal muscle following functional overloading.Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase.A heat-sensitive Arabidopsis thaliana kinase substitutes for human p70s6k function in vivo.Mitogen-activated Swiss mouse 3T3 RSK kinases I and II are related to pp44mpk from sea star oocytes and participate in the regulation of pp90rsk activity.Phosphatidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylationThe modular phosphorylation and activation of p70s6k.Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K.Activation of the pp90rsk and mitogen-activated serine/threonine protein kinases by ionizing radiation.A Drosophila gene structurally and functionally homologous to the mammalian 70-kDa s6 kinase gene.mTOR coordinates protein synthesis, mitochondrial activity and proliferation.Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by phosphatidylinositol 3-kinase and inhibited by cyclic AMP.Extracellular signal-regulated kinases: ERKs in progress.Activation of p70s6k is associated with phosphorylation of four clustered sites displaying Ser/Thr-Pro motifsInterleukin 2 stimulation of p70 S6 kinase activity is inhibited by the immunosuppressant rapamycin.Phosphorylation and degradation of S6K1 (p70S6K1) in response to persistent JNK1 Activation.Phosphoinositide 3-kinase signaling in the vertebrate retina.The role of mammalian target of rapamycin (mTOR) in the regulation of pancreatic β-cell mass: implications in the development of type-2 diabetes.Regulation of mRNA translation by signaling pathwaysThe role of mTORC1 in regulating protein synthesis and skeletal muscle mass in response to various mechanical stimuli.Mechanisms of translation control underlying long-lasting synaptic plasticity and the consolidation of long-term memory.Increased activity of MAP, p70S6 and p90rs kinases is associated with AP-1 activation in spontaneous liver tumours, but not in adjacent tissue in mice.Multiple independent inputs are required for activation of the p70 S6 kinase.Different interactomes for p70-S6K1 and p54-S6K2 revealed by proteomic analysis.Involvement of heterogeneous ribonucleoprotein F in the regulation of cell proliferation via the mammalian target of rapamycin/S6 kinase 2 pathway.
P2860
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P2860
Molecular structure of a major insulin/mitogen-activated 70-kDa S6 protein kinase.
description
1990 nî lūn-bûn
@nan
1990 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1990 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
name
Molecular structure of a major insulin/mitogen-activated 70-kDa S6 protein kinase.
@ast
Molecular structure of a major insulin/mitogen-activated 70-kDa S6 protein kinase.
@en
type
label
Molecular structure of a major insulin/mitogen-activated 70-kDa S6 protein kinase.
@ast
Molecular structure of a major insulin/mitogen-activated 70-kDa S6 protein kinase.
@en
prefLabel
Molecular structure of a major insulin/mitogen-activated 70-kDa S6 protein kinase.
@ast
Molecular structure of a major insulin/mitogen-activated 70-kDa S6 protein kinase.
@en
P2093
P2860
P356
P1476
Molecular structure of a major insulin/mitogen-activated 70-kDa S6 protein kinase.
@en
P2093
P2860
P304
P356
10.1073/PNAS.87.21.8550
P407
P577
1990-11-01T00:00:00Z