Interleukin 2 stimulation of p70 S6 kinase activity is inhibited by the immunosuppressant rapamycin.
about
Protein phosphorylation cascades associated with methamphetamine-induced glial activation.Mutational analysis of ribosomal S6 kinase 2 shows differential regulation of its kinase activity from that of ribosomal S6 kinase 1The 25-kDa FK506-binding protein is localized in the nucleus and associates with casein kinase II and nucleolinTOR controls translation initiation and early G1 progression in yeastCharacterization of S6K2, a novel kinase homologous to S6K1Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cellsIdentification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residueInsulin activates a PD 098059-sensitive kinase that is involved in the regulation of p70S6K and PHAS-I.Structural and functional analysis of pp70S6k.Rapamycin-resistant proliferation of CD8+ T cells correlates with p27kip1 down-regulation and bcl-xL induction, and is prevented by an inhibitor of phosphoinositide 3-kinase activity.Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicityRibosomal p70S6K basal activity increases upon induction of differentiation of myelomonocytic leukemic cell lines HL60, AML14 and MPDMolecular crosstalk between p70S6k and MAPK cell signaling pathways.Immunosuppressant FK506 promotes neurite outgrowth in cultures of PC12 cells and sensory gangliaModulation of immune cell proliferation by glycerol monolaurate.Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family.Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins.Targeted disruption of p70(s6k) defines its role in protein synthesis and rapamycin sensitivity.Interleukin 2 activates extracellular signal-regulated protein kinase 2.Signal transduction via the MAP kinases: proceed at your own RSK.Interleukin-2 triggers a novel phosphatidylinositol 3-kinase-dependent MEK activation pathway.Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by phosphatidylinositol 3-kinase and inhibited by cyclic AMP.Defects in skin gamma delta T cell function contribute to delayed wound repair in rapamycin-treated micePhospho-p70S6K and cdc2/cdk1 as therapeutic targets for diffuse large B-cell lymphoma.Global and specific translational control by rapamycin in T cells uncovered by microarrays and proteomics.Interleukin 4-inducible phosphorylation of HMG-I(Y) is inhibited by rapamycin.Catalytic and ligand binding properties of the FK506 binding protein FKBP12: effects of the single amino acid substitution of Tyr82 to LeuInterleukin-2 activation of STAT5 requires the convergent action of tyrosine kinases and a serine/threonine kinase pathway distinct from the Raf1/ERK2 MAP kinase pathway.Rapamycin specifically interferes with the developmental response of fission yeast to starvation.Constitutive activation of S6 kinase by deletion of amino-terminal autoinhibitory and rapamycin sensitivity domains.S6 phosphorylation and the p70s6k/p85s6k.Nuclear localization of p85s6k: functional requirement for entry into S phase.Osmotic stress inhibits p70/85 S6 kinase through activation of a protein phosphatase.STAT3 is a serine kinase target in T lymphocytes. Interleukin 2 and T cell antigen receptor signals converge upon serine 727.T cell proliferation in response to interleukins 2 and 7 requires p38MAP kinase activation.FK-506 and rapamycin but not cyclosporin inhibit aldosterone-stimulated sodium transport in A6 cells.Role of p70 S6 kinase in cytokine-regulated hemopoietic cell survival.Wortmannin inhibits the effects of insulin and serum on the activities of glycogen synthase kinase-3 and mitogen-activated protein kinasep21ras couples the T cell antigen receptor to extracellular signal-regulated kinase 2 in T lymphocytes.
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Interleukin 2 stimulation of p70 S6 kinase activity is inhibited by the immunosuppressant rapamycin.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on August 1992
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Interleukin 2 stimulation of p ...... e immunosuppressant rapamycin.
@en
Interleukin 2 stimulation of p ...... e immunosuppressant rapamycin.
@nl
type
label
Interleukin 2 stimulation of p ...... e immunosuppressant rapamycin.
@en
Interleukin 2 stimulation of p ...... e immunosuppressant rapamycin.
@nl
prefLabel
Interleukin 2 stimulation of p ...... e immunosuppressant rapamycin.
@en
Interleukin 2 stimulation of p ...... e immunosuppressant rapamycin.
@nl
P2093
P2860
P356
P1476
Interleukin 2 stimulation of p ...... e immunosuppressant rapamycin.
@en
P2093
P2860
P304
P356
10.1073/PNAS.89.16.7571
P407
P577
1992-08-01T00:00:00Z