A lipid pathway for ligand binding is necessary for a cannabinoid G protein-coupled receptor
about
High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875Crystal structure of a lipid G protein-coupled receptorThe serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2-arachidonoylglycerol signalling through cannabinoid receptorsEndogenous lipid activated G protein-coupled receptors: emerging structural features from crystallography and molecular dynamics simulationsThe pathway of ligand entry from the membrane bilayer to a lipid G protein-coupled receptor.Targeting Cannabinoid CB2 Receptors in the Central Nervous System. Medicinal Chemistry Approaches with Focus on Neurodegenerative DisordersRole of Annular Lipids in the Functional Properties of Leucine Transporter LeuT ProteomicellesShowcasing modern molecular dynamics simulations of membrane proteins through G protein-coupled receptors.Pathway and mechanism of drug binding to G-protein-coupled receptors.Chromenopyrazoles: non-psychoactive and selective CB₁ cannabinoid agonists with peripheral antinociceptive propertiesMembrane cholesterol access into a G-protein-coupled receptor.Mapping Cannabinoid 1 Receptor Allosteric Site(s): Critical Molecular Determinant and Signaling Profile of GAT100, a Novel, Potent, and Irreversibly Binding Probe.Difference and Influence of Inactive and Active States of Cannabinoid Receptor Subtype CB2: From Conformation to Drug Discovery.Minireview: recent developments in the physiology and pathology of the lysophosphatidylinositol-sensitive receptor GPR55.High-resolution crystal structure of the human CB1 cannabinoid receptor.Global fold of human cannabinoid type 2 receptor probed by solid-state 13C-, 15N-MAS NMR and molecular dynamics simulations.Identification of the GPR55 agonist binding site using a novel set of high-potency GPR55 selective ligands.Structural basis of G protein-coupled receptor-Gi protein interaction: formation of the cannabinoid CB2 receptor-Gi protein complexCholesterol modulates the membrane effects and spatial organization of membrane-penetrating ligands for G-protein coupled receptorsThe future of molecular dynamics simulations in drug discovery.Ligand-dependent conformations and dynamics of the serotonin 5-HT(2A) receptor determine its activation and membrane-driven oligomerization propertiesDesign and pharmacological characterization of VUF14480, a covalent partial agonist that interacts with cysteine 98(3.36) of the human histamine H₄ receptor.Virtual screening of CB(2) receptor agonists from bayesian network and high-throughput docking: structural insights into agonist-modulated GPCR features.CB2-selective cannabinoid receptor ligands: synthesis, pharmacological evaluation, and molecular modeling investigation of 1,8-Naphthyridin-2(1H)-one-3-carboxamides.Exploring binding properties of agonists interacting with a δ-opioid receptor.Allosteric Modulation: An Alternate Approach Targeting the Cannabinoid CB1 Receptor.(4-(Bis(4-fluorophenyl)methyl)piperazin-1-yl)(cyclohexyl)methanone hydrochloride (LDK1229): a new cannabinoid CB1 receptor inverse agonist from the class of benzhydryl piperazine analogs.Role of membrane integrity on G protein-coupled receptors: Rhodopsin stability and function.Identification of the GPR55 antagonist binding site using a novel set of high-potency GPR55 selective ligands.Endocannabinoid tone versus constitutive activity of cannabinoid receptors.AM841, a covalent cannabinoid ligand, powerfully slows gastrointestinal motility in normal and stressed mice in a peripherally restricted manner.From G Protein-coupled Receptor Structure Resolution to Rational Drug Design.Recombinant cannabinoid type 2 receptor in liposome model activates g protein in response to anionic lipid constituents.CB2 cannabinoid receptor agonist enantiomers HU-433 and HU-308: An inverse relationship between binding affinity and biological potencyAgonist dynamics and conformational selection during microsecond simulations of the A(2A) adenosine receptorConformational dynamics of activation for the pentameric complex of dimeric G protein-coupled receptor and heterotrimeric G protein.Elastic Network Models are Robust to Variations in FormalismCan Specific Protein-Lipid Interactions Stabilize an Active State of the Beta 2 Adrenergic Receptor?A key agonist-induced conformational change in the cannabinoid receptor CB1 is blocked by the allosteric ligand Org 27569.Molecular-interaction and signaling profiles of AM3677, a novel covalent agonist selective for the cannabinoid 1 receptor.
P2860
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P2860
A lipid pathway for ligand binding is necessary for a cannabinoid G protein-coupled receptor
description
2010 nî lūn-bûn
@nan
2010 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մարտին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
A lipid pathway for ligand bin ...... oid G protein-coupled receptor
@ast
A lipid pathway for ligand bin ...... oid G protein-coupled receptor
@en
type
label
A lipid pathway for ligand bin ...... oid G protein-coupled receptor
@ast
A lipid pathway for ligand bin ...... oid G protein-coupled receptor
@en
prefLabel
A lipid pathway for ligand bin ...... oid G protein-coupled receptor
@ast
A lipid pathway for ligand bin ...... oid G protein-coupled receptor
@en
P2093
P2860
P921
P356
P1476
A lipid pathway for ligand bin ...... oid G protein-coupled receptor
@en
P2093
Diane L Lynch
Dow P Hurst
Klaus Gawrisch
Michael C Pitman
Patricia H Reggio
Scott Feller
Tod D Romo
P2860
P304
17954-17964
P356
10.1074/JBC.M109.041590
P407
P577
2010-03-10T00:00:00Z