Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes. - Wikidata - wikimedia - TriplyDB

Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes.

Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes.

http://www.wikidata.org/entity/Q33885674

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Targeting leukemia stem cells: which pathways drive self-renewal activity in T-cell acute lymphoblastic leukemia?The LMO2 oncogene regulates DNA replication in hematopoietic cells Transcriptional establishment of cell-type identity: dynamics and causal mechanisms of T-cell lineage commitment.Illegitimate V(D)J recombination-mediated deletions in Notch1 and Bcl11b are not sufficient for extensive clonal expansion and show minimal age or sex bias in frequency or junctional processing.Enhanced Notch activation is advantageous but not essential for T cell lymphomagenesis in Id1 transgenic mice Fli-1 overexpression in hematopoietic progenitors deregulates T cell development and induces pre-T cell lymphoblastic leukaemia/lymphoma.SCL, LMO1 and Notch1 reprogram thymocytes into self-renewing cells Prdm14 initiates lymphoblastic leukemia after expanding a population of cells resembling common lymphoid progenitors.Notch1 inhibition targets the leukemia-initiating cells in a Tal1/Lmo2 mouse model of T-ALL.High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling.Controlling pre-leukemic thymocyte self-renewal.Trib2 Suppresses Tumor Initiation in Notch-Driven T-ALL.Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia.High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells.Mouse Lymphoblastic Leukemias Induced by Aberrant Prdm14 Expression Demonstrate Widespread Copy Number Alterations Also Found in Human ALL.Bivalent promoter marks and a latent enhancer may prime the leukaemia oncogene LMO1 for ectopic expression in T-cell leukaemia.Pbx1 restrains myeloid maturation while preserving lymphoid potential in hematopoietic progenitors.The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia NOTCH1 promotes T cell leukemia-initiating activity by RUNX-mediated regulation of PKC-θ and reactive oxygen species.LMO1 gene polymorphisms contribute to decreased neuroblastoma susceptibility in a Southern Chinese population.The TCR γδ repertoire and relative gene expression characteristics of T-ALL cases with biclonal malignant Vδ1 and Vδ2 T cells.c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells.Concise review: Blood relatives: formation and regulation of hematopoietic stem cells by the basic helix-loop-helix transcription factors stem cell leukemia and lymphoblastic leukemia-derived sequence 1.LIM-domain-only proteins in cancer.LIM-domain-only proteins: multifunctional nuclear transcription coregulators that interacts with diverse proteins.FOXP3 can modulate TAL1 transcriptional activity through interaction with LMO2.Microenvironmental cues for T-cell acute lymphoblastic leukemia development.Enforced expression of E47 has differential effects on Lmo2-induced T-cell leukemias.Epigenetic regulation of the Ink4a-Arf (Cdkn2a) tumor suppressor locus in the initiation and progression of Notch1-driven T cell acute lymphoblastic leukemia.Notch signaling expands a pre-malignant pool of T-cell acute lymphoblastic leukemia clones without affecting leukemia-propagating cell frequency.Modelling acute leukemias in mice: clonal evolution and the emergence of leukemic stem cells.Aberrant activation of the GIMAP enhancer by oncogenic transcription factors in T-cell acute lymphoblastic leukemia.Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders.Placing ion channels into a signaling network of T cells: from maturing thymocytes to healthy T lymphocytes or leukemic T lymphoblasts.A TCR-switchable cell death pathway in T-ALL.Leukemia-Initiating Cells in T-Cell Acute Lymphoblastic Leukemia.Applicability of gene expression profile of childhood acute lymphoblastic leukemia at diagnosis and at the end of the induction phase of chemotherapy at a cancer hospital in the state of Goiás (Brazil).Loss-of-function mutations of Dynamin 2 promote T-ALL by enhancing IL-7 signalling.Hhex regulates Kit to promote radioresistance of self-renewing thymocytes in Lmo2-transgenic mice.Leukemia stem cells.

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Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes.

http://www.wikidata.org/entity/Q33885674

description

2010 nî lūn-bûn

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2010 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2010 թվականի հունիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes.

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Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes.

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type

label

Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes.

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Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes.

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prefLabel

Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes.

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Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes.

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Genes & Development

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Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes

@en

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Cédric S Tremblay

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Josée Hébert

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Mathieu Tremblay

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Peter D Aplan

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Sabine Herblot

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Trang Hoang

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The Hallmarks of Cancer

Notch3 and pre-TCR interaction unveils distinct NF-kappaB pathways in T-cell development and leukemia.

The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13

A genetic model for colorectal tumorigenesis

A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

Disordered T-cell development and T-cell malignancies in SCL LMO1 double-transgenic mice: parallels with E2A-deficient mice

Scl regulates the quiescence and the long-term competence of hematopoietic stem cells

Thymic overexpression of Ttg-1 in transgenic mice results in T-cell acute lymphoblastic leukemia/lymphoma

No requirement for V(D)J recombination in p53-deficient thymic lymphoma

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

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1093-1105

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scholarly article

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10.1101/GAD.1897910

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11

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24

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Claude Perreault

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2010-06-01T00:00:00Z

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44643218

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20516195

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2878648

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