Ku protein stimulates DNA end joining by mammalian DNA ligases: a direct role for Ku in repair of DNA double-strand breaks.
about
DNA end-joining catalyzed by human cell-free extractsKu complex interacts with and stimulates the Werner proteinA functional interaction of Ku with Werner exonuclease facilitates digestion of damaged DNAThe role of DNA polymerase activity in human non-homologous end joiningIn vitro and in vivo interactions of DNA ligase IV with a subunit of the condensin complexDNA binding of Xrcc4 protein is associated with V(D)J recombination but not with stimulation of DNA ligase IV activityInvolvement of human polynucleotide kinase in double-strand break repair by non-homologous end joiningSynapsis of DNA ends by DNA-dependent protein kinaseKu recruits the XRCC4-ligase IV complex to DNA endsNbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complexHuman securin, hPTTG, is associated with Ku heterodimer, the regulatory subunit of the DNA-dependent protein kinaseProkaryotic homologs of the eukaryotic DNA-end-binding protein Ku, novel domains in the Ku protein and prediction of a prokaryotic double-strand break repair systemA human XRCC4-XLF complex bridges DNAXLF-Cernunnos promotes DNA ligase IV-XRCC4 re-adenylation following ligationBiochemical evidence for Ku-independent backup pathways of NHEJHomologous Recombination and Its Role in CarcinogenesisXRCC4:DNA ligase IV can ligate incompatible DNA ends and can ligate across gapsProcessing of damaged DNA ends for double-strand break repair in mammalian cellsUbiquitylation, neddylation and the DNA damage responseTRF2 interaction with Ku heterotetramerization interface gives insight into c-NHEJ prevention at human telomeresInteractions of the DNA ligase IV-XRCC4 complex with DNA ends and the DNA-dependent protein kinaseFunctional interaction between Ku and the werner syndrome protein in DNA end processingDNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformationThe biochemistry and biological significance of nonhomologous DNA end joining: an essential repair process in multicellular eukaryotesLoss of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) expression in gastric cancersSibling rivalry: competition between Pol X family members in V(D)J recombination and general double strand break repairThe taming of a transposon: V(D)J recombination and the immune systemThe minimal Bacillus subtilis nonhomologous end joining repair machineryHMG1 protein stimulates DNA end joining by promoting association of DNA molecules via their endsInteraction of Ku protein and DNA-dependent protein kinase catalytic subunit with nucleic acidsKinetic analysis of the Ku-DNA binding activity reveals a redox-dependent alteration in protein structure that stimulates dissociation of the Ku-DNA complexA noncatalytic function of the ligation complex during nonhomologous end joining.Coordinate action of the helicase and 3' to 5' exonuclease of Werner syndrome protein.Two-Stage Synapsis of DNA Ends during Non-homologous End Joining.Requirements for the nucleolytic processing of DNA ends by the Werner syndrome protein-Ku70/80 complex.Reconstitution of the mammalian DNA double-strand break end-joining reaction reveals a requirement for an Mre11/Rad50/NBS1-containing fraction.Analysis of variable (diversity) joining recombination in DNAdependent protein kinase (DNA-PK)-deficient mice reveals DNA-PK-independent pathways for both signal and coding joint formation.Nonhomologous DNA end joining in cell-free systems.An alternate form of Ku80 is required for DNA end-binding activity in mammalian mitochondria.Radiation-generated short DNA fragments may perturb non-homologous end-joining and induce genomic instability
P2860
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P2860
Ku protein stimulates DNA end joining by mammalian DNA ligases: a direct role for Ku in repair of DNA double-strand breaks.
description
1998 nî lūn-bûn
@nan
1998 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Ku protein stimulates DNA end ...... r of DNA double-strand breaks.
@ast
Ku protein stimulates DNA end ...... r of DNA double-strand breaks.
@en
type
label
Ku protein stimulates DNA end ...... r of DNA double-strand breaks.
@ast
Ku protein stimulates DNA end ...... r of DNA double-strand breaks.
@en
prefLabel
Ku protein stimulates DNA end ...... r of DNA double-strand breaks.
@ast
Ku protein stimulates DNA end ...... r of DNA double-strand breaks.
@en
P2860
P356
P1433
P1476
Ku protein stimulates DNA end ...... r of DNA double-strand breaks.
@en
P2093
D A Ramsden
P2860
P304
P356
10.1093/EMBOJ/17.2.609
P407
P577
1998-01-01T00:00:00Z