XLF-Cernunnos promotes DNA ligase IV-XRCC4 re-adenylation following ligation - Wikidata - wikimedia - TriplyDB

XLF-Cernunnos promotes DNA ligase IV-XRCC4 re-adenylation following ligation

XLF-Cernunnos promotes DNA ligase IV-XRCC4 re-adenylation following ligation

http://www.wikidata.org/entity/Q24642915

about

2BN 2BNhTERT 180BRhTERT 48BRhTERT F07/402

P1343

APLF promotes the assembly and activity of non-homologous end joining protein complexes Distinct kinetics of human DNA ligases I, IIIalpha, IIIbeta, and IV reveal direct DNA sensing ability and differential physiological functions in DNA repair Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway Mouse embryonic stem cells, but not somatic cells, predominantly use homologous recombination to repair double-strand DNA breaks Structural characterization of filaments formed by human Xrcc4-Cernunnos/XLF complex involved in nonhomologous DNA end-joining XRCC4's interaction with XLF is required for coding (but not signal) end joining The role of RecQ helicases in non-homologous end-joining Diseases associated with defective responses to DNA damage XRCC4 Protein Interactions with XRCC4-like Factor (XLF) Create an Extended Grooved Scaffold for DNA Ligation and Double Strand Break Repair Non-homologous end-joining partners in a helical dance: structural studies of XLF-XRCC4 interactions Structural Insights into the Role of Domain Flexibility in Human DNA Ligase IV Yeast Nej1 is a key participant in the initial end binding and final ligation steps of nonhomologous end joining.Role of non-homologous end joining in V(D)J recombination Evaluation of Severe Combined Immunodeficiency and Combined Immunodeficiency Pediatric Patients on the Basis of Cellular Radiosensitivity.A noncatalytic function of the ligation complex during nonhomologous end joining.Homozygous DNA ligase IV R278H mutation in mice leads to leaky SCID and represents a model for human LIG4 syndrome Non-homologous end joining: emerging themes and unanswered questions.The C-terminus of Nej1 is critical for nuclear localization and non-homologous end-joining.Delineation of the Xrcc4-interacting region in the globular head domain of cernunnos/XLF.Cernunnos influences human immunoglobulin class switch recombination and may be associated with B cell lymphomagenesis XRCC4 and XLF form long helical protein filaments suitable for DNA end protection and alignment to facilitate DNA double strand break repair.XLF regulates filament architecture of the XRCC4·ligase IV complex.Non-homologous end joining: Common interaction sites and exchange of multiple factors in the DNA repair process.A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation Saccharomyces cerevisiae DNA ligase IV supports imprecise end joining independently of its catalytic activity.Electron microscopy visualization of DNA-protein complexes formed by Ku and DNA ligase IV XRCC4/XLF Interaction Is Variably Required for DNA Repair and Is Not Required for Ligase IV Stimulation RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair Cernunnos deficiency reduces thymocyte life span and alters the T cell repertoire in mice and humans.The FHA and BRCT domains recognize ADP-ribosylation during DNA damage response.Role of the yeast DNA repair protein Nej1 in end processing during the repair of DNA double strand breaks by non-homologous end joining Human induced pluripotent cells resemble embryonic stem cells demonstrating enhanced levels of DNA repair and efficacy of nonhomologous end-joining.An Intrinsically Disordered APLF Links Ku, DNA-PKcs, and XRCC4-DNA Ligase IV in an Extended Flexible Non-homologous End Joining Complex.PAXX promotes KU accumulation at DNA breaks and is essential for end-joining in XLF-deficient mice.A role for XLF in DNA repair and recombination in human somatic cells.CRISPR as a strong gene editing tool.Detection and repair of ionizing radiation-induced DNA double strand breaks: new developments in nonhomologous end joining.Repair of double-strand breaks by end joining.The spatial organization of non-homologous end joining: from bridging to end joining.Functional overlaps between XLF and the ATM-dependent DNA double strand break response.

P2860

Q54584316-94D6243F-84CD-418E-846D-DB044B026DC0 Q54584319-A4A87917-5BBD-414C-9AB7-A7EE0F76770D Q93300273-3D9DEA52-860A-4714-88BF-DD68185643A5 Q93307164-EB67CD80-D8DE-4FCB-B251-D7B88AB354CA Q93547672-2F0DC20F-EF2B-42B6-B5DD-5AE277D83CFE

P1343

Q24304501-AF8FDF45-DAC8-436A-9075-50552B8AF1C4 Q24312226-6A42D58E-C800-4B4A-B313-0D90902ED34D Q24318661-78D41B77-C03E-4FAC-A195-6A402FA79B97 Q24599990-CE4B0721-0AF7-41FB-928B-679E5FBA7569 Q24622950-212DC7A2-62DE-473A-80E0-CFAFDBE62992 Q24630098-3DF0042F-0C75-46BA-893B-42141FA4E7F5 Q26829119-9106C85A-7F55-4297-8415-A3E975A2FD7D Q26997852-CF94FF45-791F-4697-A168-F0F1E9673726 Q27670908-77C80233-051C-4976-9A6B-07B4534B2083 Q27674365-C08300EF-FC68-47FF-8B22-4B5E359EC33F Q27679426-5E1C752B-4FF2-43D6-A968-023DCF16F41A Q27933248-85F90CED-1024-4389-ADAB-8BD22A226EC4 Q28266265-CCA3E854-6E50-4AF3-B6E0-4FA68D2ED21F Q30389807-30981602-9274-4E0C-9762-A5F8408EF8E1 Q30418148-CC43C5FD-3E07-4063-AEE8-FC8B7B2272D6 Q33733794-4E83A0DD-03AF-43EE-B8A3-411F7A7F0680 Q33854272-8B1E1A7B-9212-4352-844D-3FCABB6BC048 Q34004894-D6296632-AA6B-44DF-BEEC-5B2BDCB7FAA7 Q34074446-25AEE438-0354-4567-B68F-10082EE0D1C6 Q34152519-5ADE1C22-1EBB-4A61-BD86-3C835D279E5A Q34329896-3EDC64A1-185E-4799-959A-1B45EC86CED3 Q34433470-A5D2B3FE-4317-4CCF-B36C-7551F10C0343 Q34550224-47799674-3398-4269-813A-7FA233869F85 Q34610477-71935AFD-B434-4481-9459-B7D2B8C03918 Q34795549-2146AC75-AF16-439D-B381-A76A11FE72D2 Q35661237-4C36B71B-7F4B-42C1-B8D0-68B8ACDDA2F5 Q35917467-9FD16D68-6007-4C38-9073-10F0D7643236 Q36542548-C307CFC7-5988-494F-B8B2-6216D2B340B0 Q36606978-D383C8DE-475B-4754-89F4-29DD8E1A29AB Q37138573-9F967EA3-8A6E-418F-BFAB-DCF44404B44D Q37289660-3FBE10D4-4F1C-4F35-9377-C93111483EEE Q37414043-2FDD6D49-1636-4B75-80C2-07B2D2BA4FC2 Q37551399-CDC5488A-3BA4-4BC8-9229-A051BFEC1BCC Q37562697-E6B95D28-1684-42B0-9447-28FD41525062 Q37628142-4E99FC66-A706-4E41-BC17-DEAED1262760 Q37656508-8DD13F60-C418-47B7-B2CB-B0B035C29C66 Q38083939-28A18AE0-1305-4A02-8C2A-8B1907A23FD0 Q38103528-F70339C3-3431-4DA8-A640-05F759E6E16A Q38196597-913A2F1D-ADE2-4B19-AB50-6E8979DD5A30 Q38199848-4AAEF940-57D9-4078-A50D-3BD7B9C9D33F

P2860

XLF-Cernunnos promotes DNA ligase IV-XRCC4 re-adenylation following ligation

http://www.wikidata.org/entity/Q24642915

description

2009 nî lūn-bûn

@nan

2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2009年の論文

@ja

2009年論文

@yue

2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

@zh-tw

2009年论文

@wuu

name

XLF-Cernunnos promotes DNA ligase IV-XRCC4 re-adenylation following ligation

@ast

XLF-Cernunnos promotes DNA ligase IV-XRCC4 re-adenylation following ligation

@en

XLF-Cernunnos promotes DNA ligase IV-XRCC4 re-adenylation following ligation

@nl

type

label

XLF-Cernunnos promotes DNA ligase IV-XRCC4 re-adenylation following ligation

@ast

XLF-Cernunnos promotes DNA ligase IV-XRCC4 re-adenylation following ligation

@en

XLF-Cernunnos promotes DNA ligase IV-XRCC4 re-adenylation following ligation

@nl

prefLabel

XLF-Cernunnos promotes DNA ligase IV-XRCC4 re-adenylation following ligation

@ast

XLF-Cernunnos promotes DNA ligase IV-XRCC4 re-adenylation following ligation

@en

XLF-Cernunnos promotes DNA ligase IV-XRCC4 re-adenylation following ligation

@nl

P1433

Q24642915-C5604725-42E3-44E4-BAA2-46504306AD2B

P1476

Q24642915-59C2B575-AE86-4DD9-806D-62FAEA0B5F70

P2093

Q24642915-230B6B6E-0D07-4F63-BCE5-C86816F58D3C

Q24642915-3F2672A2-A97E-4D54-8F01-4EB6C88649B9

Q24642915-64BA858E-D3C3-4D69-9CBB-4A46C75407AB

Q24642915-7CDDF0A1-803E-45B5-A788-0E690D890575

Q24642915-AC91D5D5-2AEC-4DC8-B139-0046BA29CD37

Q24642915-C72C884A-E7B3-4C02-A63E-256D5ABC4246

P2860

Q24642915-060E97D3-B49C-492E-97F0-8B99FF70EF87

Q24642915-17D23BAD-1883-4ADD-B2EF-68D4C044FC37

Q24642915-1D41CF23-6BE7-4F40-8879-EFA3DE234865

Q24642915-1FA175A4-E955-4C5F-A43C-35EAB03591F7

Q24642915-24EAD6B2-3CAC-4711-B985-82CD527D0292

Q24642915-271B9A16-679F-477A-8682-94785FC5B05F

Q24642915-29527783-15EE-46CF-AED0-2AE45D1D94E1

Q24642915-2B88D8C3-C385-4CEB-9639-2ACF9D9FE143

Q24642915-2F28B24A-DE0B-44AC-A579-60F425523BFA

Q24642915-33402FBF-EB18-4C89-8EDB-F4CD532B8BFB

P304

Q24642915-B24D7695-ADB5-45EE-83DA-B7EDD2431E54

P31

Q24642915-B03F59F0-71AF-4017-A0EA-A5C4CA147503

P3181

Q24642915-84328EBA-ECE7-49A5-945F-C562340AEC21

P356

Q24642915-222724AA-DCA0-44A4-9013-DB8B60098FBE

P407

Q24642915-DB97D782-C2AC-43D8-88E7-5B2D3E299CEF

P433

Q24642915-BB06BE53-24B5-47E8-9E39-8B303ADB7BAB

P478

Q24642915-AEB70237-1E47-495B-A5F2-BEE4ED9F4FBE

P577

Q24642915-251866D1-0008-4B8D-B759-E9BD046B4553

P5875

Q24642915-9D855C5F-5C87-4D78-8AC1-E9D204958736

P698

Q24642915-D5DEDC48-1EC4-44C2-AC83-A673F639CE15

P932

Q24642915-0A56E424-8FF8-4B4F-9625-D45F8FCA8597

P3181

P356

P1433

Nucleic Acids Research

P1476

XLF-Cernunnos promotes DNA ligase IV-XRCC4 re-adenylation following ligation

@en

P2093

Aaron A Goodarzi

http://www.w3.org/2001/XMLSchema#string

Enriqueta Riballo

http://www.w3.org/2001/XMLSchema#string

Lisa Woodbine

http://www.w3.org/2001/XMLSchema#string

Penny A Jeggo

http://www.w3.org/2001/XMLSchema#string

Sarah A Walker

http://www.w3.org/2001/XMLSchema#string

Thomas Stiff

http://www.w3.org/2001/XMLSchema#string

P2860

Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly

XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining

Ku recruits XLF to DNA double-strand breaks

Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells

Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV

DNA binding of Xrcc4 protein is associated with V(D)J recombination but not with stimulation of DNA ligase IV activity

Nonhomologous end joining and V(D)J recombination require an additional factor

Ku recruits the XRCC4-ligase IV complex to DNA ends

Lymphocyte-specific compensation for XLF/cernunnos end-joining functions in V(D)J recombination

Cernunnos/XLF promotes the ligation of mismatched and noncohesive DNA ends

P304

482-92

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

3748386

http://www.w3.org/2001/XMLSchema#string

P356

10.1093/NAR/GKN957

http://www.w3.org/2001/XMLSchema#string

P407

P433

2

http://www.w3.org/2001/XMLSchema#string

P478

37

http://www.w3.org/2001/XMLSchema#string

P577

2009-02-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

23571770

http://www.w3.org/2001/XMLSchema#string

P698

19056826

http://www.w3.org/2001/XMLSchema#string

P932

2632933

http://www.w3.org/2001/XMLSchema#string