Discovery of positive allosteric modulators of metabotropic glutamate receptor subtype 5 (mGluR5).
about
Synthesis, SAR and unanticipated pharmacological profiles of analogues of the mGluR5 ago-potentiator ADX-47273Synthesis and SAR of a mGluR5 allosteric partial antagonist lead: unexpected modulation of pharmacology with slight structural modifications to a 5-(phenylethynyl)pyrimidine scaffold.Tetrahydronaphthyridine and dihydronaphthyridinone ethers as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu₅).Progress toward positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5).PET imaging studies show enhanced expression of mGluR5 and inflammatory response during progressive degeneration in ALS mouse model expressing SOD1-G93A geneUnifying electrostatic mechanism for receptor-ligand activity.Autism spectrum disorder causes, mechanisms, and treatments: focus on neuronal synapses.Allosteric modulators for the treatment of schizophrenia: targeting glutamatergic networks"Molecular switches" on mGluR allosteric ligands that modulate modes of pharmacology.Allosteric modulation of Class C GPCRs: a novel approach for the treatment of CNS disorders.Metabotropic glutamate receptor 5-positive allosteric modulators for the treatment of schizophrenia (2004-2012).Discovery and SAR of novel mGluR5 non-competitive antagonists not based on an MPEP chemotype.Discovery and SAR of a novel series of metabotropic glutamate receptor 5 positive allosteric modulators with high ligand efficiencySynthesis and SAR of centrally active mGlu5 positive allosteric modulators based on an aryl acetylenic bicyclic lactam scaffold.Discovery and SAR of a novel series of non-MPEP site mGlu₅ PAMs based on an aryl glycine sulfonamide scaffold.Optimization of an ether series of mGlu5 positive allosteric modulators: molecular determinants of MPEP-site interaction crossover.
P2860
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P2860
Discovery of positive allosteric modulators of metabotropic glutamate receptor subtype 5 (mGluR5).
description
2005 nî lūn-bûn
@nan
2005 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Discovery of positive alloster ...... e receptor subtype 5 (mGluR5).
@ast
Discovery of positive alloster ...... e receptor subtype 5 (mGluR5).
@en
type
label
Discovery of positive alloster ...... e receptor subtype 5 (mGluR5).
@ast
Discovery of positive alloster ...... e receptor subtype 5 (mGluR5).
@en
prefLabel
Discovery of positive alloster ...... e receptor subtype 5 (mGluR5).
@ast
Discovery of positive alloster ...... e receptor subtype 5 (mGluR5).
@en
P356
P1476
Discovery of positive alloster ...... e receptor subtype 5 (mGluR5).
@en
P2093
David L Williams
P304
P356
10.2174/1568026054750290
P577
2005-01-01T00:00:00Z