Mouse model of human beta zero thalassemia: targeted deletion of the mouse beta maj- and beta min-globin genes in embryonic stem cells.
about
An abundant erythroid protein that stabilizes free alpha-haemoglobinInduction of human fetal globin gene expression by a novel erythroid factor, NF-E4Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic miceBP1 is a negative modulator of definitive erythropoiesisThe GATA1-HS2 enhancer allows persistent and position-independent expression of a β-globin transgeneAnimal models of β-hemoglobinopathies: utility and limitationsβ-thalassemias: paradigmatic diseases for scientific discoveries and development of innovative therapiesA mouse model for beta 0-thalassemiaTherapeutic hemoglobin levels after gene transfer in β-thalassemia mice and in hematopoietic cells of β-thalassemia and sickle cells disease patientsMorphological and functional platelet abnormalities in Berkeley sickle cell mice.Gene therapy for the hemoglobin disorders: past, present, and future.Protein quality control during erythropoiesis and hemoglobin synthesisThe panoply of animal models for sickle cell anaemia.The beta-globin locus control region versus gene therapy vectors: a struggle for expression.Replication initiation patterns in the beta-globin loci of totipotent and differentiated murine cells: evidence for multiple initiation regions.Human globin knock-in mice complete fetal-to-adult hemoglobin switching in postnatal developmentAlterations in expression and chromatin configuration of the alpha hemoglobin-stabilizing protein gene in erythroid Kruppel-like factor-deficient mice.β-thalassemia: a model for elucidating the dynamic regulation of ineffective erythropoiesis and iron metabolism.Reversal of hemochromatosis by apotransferrin in non-transfused and transfused Hbbth3/+ (heterozygous B1/B2 globin gene deletion) mice.Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin.Myeloid cell-derived hypoxia-inducible factor attenuates inflammation in unilateral ureteral obstruction-induced kidney injuryCorrection of murine hemoglobinopathies by prenatal tolerance induction and postnatal nonmyeloablative allogeneic BM transplants.Use of mouse models to study the mechanisms and consequences of RBC clearance.Macrophages support pathological erythropoiesis in polycythemia vera and β-thalassemiaAnalysis of alpha hemoglobin stabilizing protein overexpression in murine β-thalassemiaDecreased differentiation of erythroid cells exacerbates ineffective erythropoiesis in beta-thalassemiaHeme degradation and oxidative stress in murine models for hemoglobinopathies: thalassemia, sickle cell disease and hemoglobin C diseaseErythropoiesis in the absence of adult hemoglobin.Humanized Mouse Model of Cooley's Anemia.Preclinical transfusion-dependent humanized mouse model of beta thalassemia major.Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cellsRegulation of iron absorption in hemoglobinopathies.Magnetic resonance evidence of hypoxia in a homozygous alpha-knockout of a transgenic mouse model for sickle cell disease.Intestinal HIF2α promotes tissue-iron accumulation in disorders of iron overload with anemia.Non-invasive MRI biomarkers for the early assessment of iron overload in a humanized mouse model of β-thalassemia.Anemia, ineffective erythropoiesis, and hepcidin: interacting factors in abnormal iron metabolism leading to iron overload in β-thalassemia.Gene therapy in thalassemia and hemoglobinopathies.Recent advances in gene therapy for thalassemia.Development of gene therapy for thalassemia.Klf1 affects DNase II-alpha expression in the central macrophage of a fetal liver erythroblastic island: a non-cell-autonomous role in definitive erythropoiesis.
P2860
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P2860
Mouse model of human beta zero thalassemia: targeted deletion of the mouse beta maj- and beta min-globin genes in embryonic stem cells.
description
1995 nî lūn-bûn
@nan
1995 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Mouse model of human beta zero ...... genes in embryonic stem cells.
@ast
Mouse model of human beta zero ...... genes in embryonic stem cells.
@en
type
label
Mouse model of human beta zero ...... genes in embryonic stem cells.
@ast
Mouse model of human beta zero ...... genes in embryonic stem cells.
@en
prefLabel
Mouse model of human beta zero ...... genes in embryonic stem cells.
@ast
Mouse model of human beta zero ...... genes in embryonic stem cells.
@en
P2093
P2860
P356
P1476
Mouse model of human beta zero ...... genes in embryonic stem cells.
@en
P2093
D J Ciavatta
S C Farmer
T M Townes
P2860
P304
P356
10.1073/PNAS.92.20.9259
P407
P577
1995-09-01T00:00:00Z