Disruption of the oxysterol 7alpha-hydroxylase gene in mice.
about
Identification of IGF1, SLC4A4, WWOX, and SFMBT1 as hypertension susceptibility genes in Han Chinese with a genome-wide gene-based association studySequence alterations within CYP7B1 implicate defective cholesterol homeostasis in motor-neuron degenerationExpression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterolHuman CYP7A1 deficiency: progress and enigmasDo oxysterols control cholesterol homeostasis?Differential modulation of cellular death and survival pathways by conjugated bile acidsHidden disease susceptibility and sexual dimorphism in the heterozygous knockout of Cyp51 from cholesterol synthesisCytochrome P450s in the synthesis of cholesterol and bile acids--from mouse models to human diseases.Oxysterol 7alpha-hydroxylase (CYP39A1) in the ciliary nonpigmented epithelium of bovine eyeHuman sterol 27-hydroxylase (CYP27) overexpressor transgenic mouse model. Evidence against 27-hydroxycholesterol as a critical regulator of cholesterol homeostasisOxysterol gradient generation by lymphoid stromal cells guides activated B cell movement during humoral responsesSulphatation does not appear to be a protective mechanism to prevent oxysterol accumulation in humans and miceMoonlighting cytochrome P450 monooxygenases.Chronic intermittent psychological stress promotes macrophage reverse cholesterol transport by impairing bile acid absorption in mice.CYP7B1: one cytochrome P450, two human genetic diseases, and multiple physiological functionsInactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase.Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis.The cholesterol metabolite 25-hydroxycholesterol activates estrogen receptor α-mediated signaling in cancer cells and in cardiomyocytesCholesterol metabolism changes under long-term dietary restrictions while the cholesterol homeostasis remains unaffected in the cortex and hippocampus of aging ratsEarly onset of puberty and early ovarian failure in CYP7B1 knockout mice.The cholesterol metabolite 27-hydroxycholesterol promotes atherosclerosis via proinflammatory processes mediated by estrogen receptor alpha.Neurosteroid hydroxylase CYP7B: vivid reporter activity in dentate gyrus of gene-targeted mice and abolition of a widespread pathway of steroid and oxysterol hydroxylation.Hepatic n-3 polyunsaturated fatty acid depletion promotes steatosis and insulin resistance in mice: genomic analysis of cellular targets.Genetic connections between neurological disorders and cholesterol metabolismGender-divergent profile of bile acid homeostasis during aging of mice.Conditional Gata4 deletion in mice induces bile acid absorption in the proximal small intestine.Regulation of bile acid biosynthesis by hepatocyte nuclear factor 4alpha.27-Hydroxycholesterol: the first identified endogenous SERMCholic acid mediates negative feedback regulation of bile acid synthesis in mice.The interaction between metabolism, cancer and cardiovascular disease, connected by 27-hydroxycholesterol.Hepatic gene expression in protoporphyic Fech mice is associated with cholestatic injury but not a marked depletion of the heme regulatory pool.Hyperglycemic Ins2AkitaLdlr⁻/⁻ mice show severely elevated lipid levels and increased atherosclerosis: a model of type 1 diabetic macrovascular disease.Extra-hepatic metabolism of 7-ketocholesterol occurs by esterification to fatty acids via cPLA2α and SOAT1 followed by selective efflux to HDLIncreased synovial expression of nuclear receptors correlates with protection in pristane-induced arthritis: a possible novel genetically regulated homeostatic mechanism.Genetics of familial intrahepatic cholestasis syndromes.The oxysterol, 27-hydroxycholesterol, links cholesterol metabolism to bone homeostasis through its actions on the estrogen and liver X receptorsCYP7B1 Enzyme Deletion Impairs Reproductive Behaviors in Male MicePathway-Wide Association Study Implicates Multiple Sterol Transport and Metabolism Genes in HDL Cholesterol Regulation.Cholestenoic acid, an endogenous cholesterol metabolite, is a potent γ-secretase modulator.Analysis of HSD3B7 knockout mice reveals that a 3alpha-hydroxyl stereochemistry is required for bile acid function
P2860
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P2860
Disruption of the oxysterol 7alpha-hydroxylase gene in mice.
description
2000 nî lūn-bûn
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2000 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Disruption of the oxysterol 7alpha-hydroxylase gene in mice.
@ast
Disruption of the oxysterol 7alpha-hydroxylase gene in mice.
@en
type
label
Disruption of the oxysterol 7alpha-hydroxylase gene in mice.
@ast
Disruption of the oxysterol 7alpha-hydroxylase gene in mice.
@en
prefLabel
Disruption of the oxysterol 7alpha-hydroxylase gene in mice.
@ast
Disruption of the oxysterol 7alpha-hydroxylase gene in mice.
@en
P2093
P356
P1476
Disruption of the oxysterol 7alpha-hydroxylase gene in mice
@en
P2093
P304
16536-16542
P356
10.1074/JBC.M001811200
P407
P577
2000-06-01T00:00:00Z