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Regulation of bile acid biosynthesis by hepatocyte nuclear factor 4alpha.

Regulation of bile acid biosynthesis by hepatocyte nuclear factor 4alpha.

http://www.wikidata.org/entity/Q34478319

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OSBP-related proteins (ORPs) in human adipose depots and cultured adipocytes: evidence for impacts on the adipocyte phenotype DAX-1 acts as a novel corepressor of orphan nuclear receptor HNF4alpha and negatively regulates gluconeogenic enzyme gene expression Colesevelam hydrochloride: evidence for its use in the treatment of hypercholesterolemia and type 2 diabetes mellitus with insights into mechanism of action Bridging cell surface receptor with nuclear receptors in control of bile acid homeostasis Structural Basis of Natural Promoter Recognition by a Unique Nuclear Receptor, HNF4 : DIABETES GENE PRODUCT Crosstalk of HNF4α with extracellular and intracellular signaling pathways in the regulation of hepatic metabolism of drugs and lipids Hepatocyte nuclear factor 4alpha coordinates a transcription factor network regulating hepatic fatty acid metabolism.Identification of novel pathways that control farnesoid X receptor-mediated hypocholesterolemia.Discovering networks of perturbed biological processes in hepatocyte cultures Characterization of cardiovascular outcomes in a type 2 diabetes glucose supply and insulin demand model Expression profile analysis of the inflammatory response regulated by hepatocyte nuclear factor 4α Alterations in hepatic mRNA expression of phase II enzymes and xenobiotic transporters after targeted disruption of hepatocyte nuclear factor 4 alpha Regulation of constitutive androstane receptor and its target genes by fasting, cAMP, hepatocyte nuclear factor alpha, and the coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha Med25 is required for RNA polymerase II recruitment to specific promoters, thus regulating xenobiotic and lipid metabolism in human liver.Hepatic hepatocyte nuclear factor 4α is essential for maintaining triglyceride and cholesterol homeostasis.TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation.Cytoplasmic tyrosine phosphatase Shp2 coordinates hepatic regulation of bile acid and FGF15/19 signaling to repress bile acid synthesis.Diurnal regulation of the early growth response 1 (Egr-1) protein expression by hepatocyte nuclear factor 4alpha (HNF4alpha) and small heterodimer partner (SHP) cross-talk in liver fibrosis.Farnesoid X Receptor Agonist Represses Cytochrome P450 2D6 Expression by Upregulating Small Heterodimer Partner.Estrogen-Induced Cholestasis Leads to Repressed CYP2D6 Expression in CYP2D6-Humanized Mice Activation of bile acid biosynthesis by the p38 mitogen-activated protein kinase (MAPK): hepatocyte nuclear factor-4alpha phosphorylation by the p38 MAPK is required for cholesterol 7alpha-hydroxylase expression Short-term circadian disruption impairs bile acid and lipid homeostasis in mice.Hepatocyte Nuclear Factor 4α Controls Iron Metabolism and Regulates Transferrin Receptor 2 in Mouse Liver.Nuclear receptors HNF4α and LRH-1 cooperate in regulating Cyp7a1 in vivo.Hepatocyte-specific deletion of hepatocyte nuclear factor-4α in adult mice results in increased hepatocyte proliferation.Liver-specific hepatocyte nuclear factor-4alpha deficiency: greater impact on gene expression in male than in female mouse liver.Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis.Hepatocyte nuclear factor 4alpha contributes to thyroid hormone homeostasis by cooperatively regulating the type 1 iodothyronine deiodinase gene with GATA4 and Kruppel-like transcription factor 9.Hepatocyte nuclear factor 4alpha in the intestinal epithelial cells protects against inflammatory bowel disease Bile acids: chemistry, physiology, and pathophysiology.Sex differences in the expression of hepatic drug metabolizing enzymes.Regulation of hepatic microRNA expression by hepatocyte nuclear factor 4 alpha.Cholesterol-lowing effect of taurine in HepG2 cell.Nuclear receptor control of enterohepatic circulation.Phytochemicals targeting genes relevant for type 2 diabetes.Hepatocyte nuclear factor-4α, a multifunctional nuclear receptor associated with cardiovascular disease and cholesterol catabolism.Role of hepatocyte nuclear factor 4α (HNF4α) in cell proliferation and cancer.Peroxisome proliferator-activated receptor-gamma coactivator-1alpha activation of CYP7A1 during food restriction and diabetes is still inhibited by small heterodimer partner.Microsomal cytochrome P450 as a target for drug discovery and repurposing.Transcription factor binding site enrichment analysis predicts drivers of altered gene expression in nonalcoholic steatohepatitis.

P2860

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P2860

Regulation of bile acid biosynthesis by hepatocyte nuclear factor 4alpha.

http://www.wikidata.org/entity/Q34478319

description

2005 nî lūn-bûn

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2005 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2005 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

Regulation of bile acid biosynthesis by hepatocyte nuclear factor 4alpha.

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Regulation of bile acid biosynthesis by hepatocyte nuclear factor 4alpha.

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Regulation of bile acid biosynthesis by hepatocyte nuclear factor 4alpha.

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Regulation of bile acid biosynthesis by hepatocyte nuclear factor 4alpha.

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Regulation of bile acid biosynthesis by hepatocyte nuclear factor 4alpha.

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Regulation of bile acid biosynthesis by hepatocyte nuclear factor 4alpha.

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Regulation of bile acid biosynthesis by hepatocyte nuclear factor 4alpha.

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Regulation of bile acid biosynthesis by hepatocyte nuclear factor 4alpha.

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Regulation of bile acid biosynthesis by hepatocyte nuclear factor 4alpha.

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JLR.M500430-JLR200

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Journal of Lipid Research

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Regulation of bile acid biosynthesis by hepatocyte nuclear factor 4alpha

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Ai-Ming Yu

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Charlie C Xiang

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Frank J Gonzalez

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Gösta Eggertsen

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Junko Inoue

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Kristopher W Krausz

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Michael J Brownstein

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Sun Hee Yim

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Xiaochao Ma

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Yusuke Inoue

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P2860

Structure and chromosomal assignment of the sterol 12alpha-hydroxylase gene (CYP8B1) in human and mouse: eukaryotic cytochrome P-450 gene devoid of introns

Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

On the mechanism of bile acid inhibition of rat sterol 12alpha-hydroxylase gene (CYP8B1) transcription: roles of alpha-fetoprotein transcription factor and hepatocyte nuclear factor 4alpha

Regulation of cholesterol-7alpha-hydroxylase: BAREly missing a SHP

Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism

Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha

Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)

TNF-alpha downregulates murine hepatic growth hormone receptor expression by inhibiting Sp1 and Sp3 binding

Structure, evolution, and liver-specific expression of sterol 12alpha-hydroxylase P450 (CYP8B)

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215-227

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10.1194/JLR.M500430-JLR200

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1

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47

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Ingemar Björkhem

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7503526

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