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Regulation of hepatic metabolic pathways by the orphan nuclear receptor SHP.

Regulation of hepatic metabolic pathways by the orphan nuclear receptor SHP.

http://www.wikidata.org/entity/Q33899626

about

Endocrine fibroblast growth factors 15/19 and 21: from feast to famine Bile acid transporters in health and disease Bile acids: regulation of synthesis The bile acid sensor FXR protects against dyslipidemia and aortic plaques development induced by the HIV protease inhibitor ritonavir in mice Farnesoid X receptor: a master regulator of hepatic triglyceride and glucose homeostasis Plasticity and expanding complexity of the hepatic transcription factor network during liver development Farnesoid X receptor is essential for normal glucose homeostasis Role of nuclear receptor SHP in metabolism and cancer.Combined deletion of Fxr and Shp in mice induces Cyp17a1 and results in juvenile onset cholestasis.All-trans-retinoic acid ameliorates hepatic steatosis in mice by a novel transcriptional cascade.Hepatocyte nuclear factor 4alpha coordinates a transcription factor network regulating hepatic fatty acid metabolism.Overexpression of nuclear receptor SHP in adipose tissues affects diet-induced obesity and adaptive thermogenesis Dietary procyanidins enhance transcriptional activity of bile acid-activated FXR in vitro and reduce triglyceridemia in vivo in a FXR-dependent manner.Transcription factor Nrf2 regulates SHP and lipogenic gene expression in hepatic lipid metabolism.Disruption of an SP2/KLF6 repression complex by SHP is required for farnesoid X receptor-induced endothelial cell migration.Ligand-dependent regulation of the activity of the orphan nuclear receptor, small heterodimer partner (SHP), in the repression of bile acid biosynthetic CYP7A1 and CYP8B1 genes.Hepatocyte nuclear factor (HNF) 4α transactivation of cytochrome P450 (Cyp) 2d40 promoter is enhanced during pregnancy in mice.Dissociation of diabetes and obesity in mice lacking orphan nuclear receptor small heterodimer partner Alteration of hepatic nuclear receptor-mediated signaling pathways in hepatitis C virus patients with and without a history of alcohol drinking.Coordinated recruitment of histone methyltransferase G9a and other chromatin-modifying enzymes in SHP-mediated regulation of hepatic bile acid metabolism.The orphan nuclear receptor small heterodimer partner is required for thiazolidinedione effects in leptin-deficient mice.A pleiotropic role for the orphan nuclear receptor small heterodimer partner in lipid homeostasis and metabolic pathways.Zinc-induced Dnmt1 expression involves antagonism between MTF-1 and nuclear receptor SHP.FXR and liver carcinogenesis FXR and PXR: potential therapeutic targets in cholestasis.Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis.Crosstalk between xenobiotics metabolism and circadian clock.Interaction of Insulin Resistance and Related Genetic Variants With Triglyceride-Associated Genetic Variants The p300 acetylase is critical for ligand-activated farnesoid X receptor (FXR) induction of SHP.Bile acid signal-induced phosphorylation of small heterodimer partner by protein kinase Cζ is critical for epigenomic regulation of liver metabolic genes Bile acid signaling pathways increase stability of Small Heterodimer Partner (SHP) by inhibiting ubiquitin-proteasomal degradation.The transcription cofactor CRTC1 protects from aberrant hepatic lipid accumulation.Farnesoid X receptor-Acting through bile acids to treat metabolic disorders.Altered expression of small heterodimer partner governs cytochrome P450 (CYP) 2D6 induction during pregnancy in CYP2D6-humanized mice.Bile acid receptors in non-alcoholic fatty liver disease.Targeting orphan nuclear receptor SHP in the treatment of metabolic diseases.Epigenomic regulation of bile acid metabolism: emerging role of transcriptional cofactors.Nuclear receptor small heterodimer partner in apoptosis signaling and liver cancer.Steatosis in the liver.Regulation of anti-atherogenic apolipoprotein M gene expression by the orphan nuclear receptor LRH-1.

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P2860

Regulation of hepatic metabolic pathways by the orphan nuclear receptor SHP.

http://www.wikidata.org/entity/Q33899626

description

2005 nî lūn-bûn

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2005 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2005 թվականի հունիսին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

Regulation of hepatic metabolic pathways by the orphan nuclear receptor SHP.

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Regulation of hepatic metabolic pathways by the orphan nuclear receptor SHP.

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type

label

Regulation of hepatic metabolic pathways by the orphan nuclear receptor SHP.

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Regulation of hepatic metabolic pathways by the orphan nuclear receptor SHP.

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prefLabel

Regulation of hepatic metabolic pathways by the orphan nuclear receptor SHP.

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Regulation of hepatic metabolic pathways by the orphan nuclear receptor SHP.

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SJ.EMBOJ.7600728

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The EMBO Journal

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Regulation of hepatic metabolic pathways by the orphan nuclear receptor SHP.

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Andy Greenfield

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Konstantinos Boulias

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Krister Bamberg

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Nitsa Katrakili

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Peter Underhill

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P2860

Identification of a nuclear receptor for bile acids

Bile acids: natural ligands for an orphan nuclear receptor

Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors

Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis

Gene-specific modulation of TAF10 function by SET9-mediated methylation

Mechanisms of nutritional and hormonal regulation of lipogenesis

The orphan nuclear receptor SHP utilizes conserved LXXLL-related motifs for interactions with ligand-activated estrogen receptors

The orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: two mechanisms for repression

Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) regulates triglyceride metabolism by activation of the nuclear receptor FXR

Occupancy and function of the -150 sterol regulatory element and -65 E-box in nutritional regulation of the fatty acid synthase gene in living animals

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2624-2633

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Iannis Talianidis

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1176456

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