about
Highly prevalent putative quadruplex sequence motifs in human DNAStructure of a human telomeric DNA sequence stabilized by 8-bromoguanosine substitutions, as determined by NMR in a K+ solutionEncapsulating a single G-quadruplex aptamer in a protein nanocavityEthidium derivatives bind to G-quartets, inhibit telomerase and act as fluorescent probes for quadruplexesInteraction of an acridine dimer with DNA quadruplex structures.Natural and pharmacological regulation of telomeraseTelomerase inhibitors based on quadruplex ligands selected by a fluorescence assay.Targeting human telomerase for cancer therapeutics.Molecular crowding creates an essential environment for the formation of stable G-quadruplexes in long double-stranded DNACyclo[n]pyrroles: size and site-specific binding to G-quadruplexes.Cell senescence and telomere shortening induced by a new series of specific G-quadruplex DNA ligands.A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands.Design, synthesis and biological evaluation of a novel class of anticancer agents: anthracenylisoxazole lexitropsin conjugatesSelective recognition of parallel and anti-parallel thrombin-binding aptamer G-quadruplexes by different fluorescent dyes.Binding of gemini bisbenzimidazole drugs with human telomeric G-quadruplex dimers: effect of the spacer in the design of potent telomerase inhibitorsHuman telomeric DNA: G-quadruplex, i-motif and Watson-Crick double helix.Studies on the structure and dynamics of the human telomeric G quadruplex by single-molecule fluorescence resonance energy transfer.Telomerase inhibitors for the treatment of cancer: the current perspective.Beyond nucleic acid base pairs: from triads to heptads.Tiptoeing to chromosome tips: facts, promises and perils of today's human telomere biology.Telomere maintenance as a target for anticancer drug discovery.Explaining the varied glycosidic conformational, G-tract length and sequence preferences for anti-parallel G-quadruplexesSynthesis and Evaluation of a Rationally Designed Click-Based Library for G-Quadruplex Selective DNA Photocleavage.Interactions of a platinum-modified perylene derivative with the human telomeric G-quadruplex.Gas-phase stability of G-quadruplex DNA determined by electrospray ionization tandem mass spectrometry and molecular dynamics simulations.Telomerase: a potential therapeutic target for cancer.G-quadruplexes for luminescent sensing and logic gatesHuman telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics.Single-molecule detection of folding and unfolding of the G-quadruplex aptamer in a nanopore nanocavity.Applications of isothermal titration calorimetry in biophysical studies of G-quadruplexes.Nucleic acid-based fluorescent probes and their analytical potential.Electrolytes in biomolecular systems studied with the 3D-RISM/RISM theory.Molecular assemblies of perylene bisimide dyes in water.G-quadruplexes as potential therapeutic targets for embryonal tumors.G-quadruplex induced stabilization by 2'-deoxy-2'-fluoro-D-arabinonucleic acids (2'F-ANA).Evaluation of binding of perylene diimide and benzannulated perylene diimide ligands to DNA by electrospray ionization mass spectrometry.Different role of functional domains of hTR in DNA binding to telomere and telomerase reconstruction.Ethidium probing of the parallel double- and four-stranded structures formed by the telomeric DNA sequences dG(GT)4G and d(GT)5.Beyond Telomerase: Telomere Instability as a Novel Target for Cancer Therapy.Selective Targeting of G-Quadruplex Structures by a Benzothiazole-Based Binding Motif.
P2860
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P2860
description
2000 nî lūn-bûn
@nan
2000 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի մարտին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
G-Quadruplex DNA as a target for drug design.
@ast
G-Quadruplex DNA as a target for drug design.
@en
type
label
G-Quadruplex DNA as a target for drug design.
@ast
G-Quadruplex DNA as a target for drug design.
@en
prefLabel
G-Quadruplex DNA as a target for drug design.
@ast
G-Quadruplex DNA as a target for drug design.
@en
P356
P1476
G-Quadruplex DNA as a target for drug design.
@en
P2093
P304
P356
10.2174/1381612003400849
P577
2000-03-01T00:00:00Z