Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics. - Wikidata - wikimedia - TriplyDB

Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics.

Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics.

http://www.wikidata.org/entity/Q36959489

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Non-B DB: a database of predicted non-B DNA-forming motifs in mammalian genomes 5'-UTR RNA G-quadruplexes: translation regulation and targeting Metastases suppressor NM23-H2 interaction with G-quadruplex DNA within c-MYC promoter nuclease hypersensitive element induces c-MYC expression Zika Virus Genomic RNA Possesses Conserved G-Quadruplexes Characteristic of the Flaviviridae Family G-quadruplexes and their regulatory roles in biology Molecular dynamics simulations of G-DNA and perspectives on the simulation of nucleic acid structures Structure of the Human Telomere in K + Solution: A Stable Basket-Type G-Quadruplex with Only Two G-Tetrad Layers Self-association of short DNA loops through minor groove C:G:G:C tetrads A G-Rich Sequence within the c-kit Oncogene Promoter Forms a Parallel G-Quadruplex Having Asymmetric G-Tetrad Dynamics Solution Structure of a Unique G-Quadruplex Scaffold Adopted by a Guanosine-Rich Human Intronic Sequence Solution structures of all parallel-stranded monomeric and dimeric G-quadruplex scaffolds of the human c-kit2 promoter Structure-function studies of FMRP RGG peptide recognition of an RNA duplex-quadruplex junction Fluorine in medicinal chemistry: β-fluorination of peripheral pyrrolidines attached to acridine ligands affects their interactions with G-quadruplex DNA Solution structure of all parallel G-quadruplex formed by the oncogene RET promoter sequence Stacking of G-quadruplexes: NMR structure of a G-rich oligonucleotide with potential anti-HIV and anticancer activity RecA-Binding pilE G4 Sequence Essential for Pilin Antigenic Variation Forms Monomeric and 5′ End-Stacked Dimeric Parallel G-Quadruplexes Solution-state structure of an intramolecular G-quadruplex with propeller, diagonal and edgewise loops G-rich VEGF aptamer with locked and unlocked nucleic acid modifications exhibits a unique G-quadruplex fold Structure of the human telomere in Na+ solution: an antiparallel (2+2) G-quadruplex scaffold reveals additional diversity Monomer-dimer equilibrium for the 5'-5' stacking of propeller-type parallel-stranded G-quadruplexes: NMR structural study Duplex-quadruplex motifs in a peculiar structural organization cooperatively contribute to thrombin binding of a DNA aptamer Solution structure of a G-quadruplex bound to the bisquinolinium compound Phen-DC(3)Structure and possible function of a G-quadruplex in the long terminal repeat of the proviral HIV-1 genome Metal Cations in G-Quadruplex Folding and Stability The G4 genome Disordering of human telomeric G-quadruplex with novel antiproliferative anthrathiophenedione Finding and characterizing the complexes of drug like molecules with quadruplex DNA: combined use of an enhanced hydroxyl radical cleavage protocol and NMR An RNA-binding Protein, Lin28, Recognizes and Remodels G-quartets in the MicroRNAs (miRNAs) and mRNAs It Regulates MoD-QM/MM Structural Refinement Method: Characterization of Hydrogen Bonding in the Oxytricha nova G-Quadruplex Single-molecule imaging reveals a common mechanism shared by G-quadruplex-resolving helicases Human DHX9 helicase unwinds triple-helical DNA structures Conserved presence of G-quadruplex forming sequences in the Long Terminal Repeat Promoter of Lentiviruses Visualization of long human telomere mimics by single-molecule fluorescence imaging Topology of a G-quadruplex DNA formed by C9orf72 hexanucleotide repeats associated with ALS and FTD.G-quadruplexes with (4n - 1) guanines in the G-tetrad core: formation of a G-triad·water complex and implication for small-molecule binding Suppression of hPOT1 in diploid human cells results in an hTERT-dependent alteration of telomere length dynamics.Genome-wide analyses of recombination prone regions predict role of DNA structural motif in recombination.Human telomeres that contain (CTAGGG)n repeats show replication dependent instability in somatic cells and the male germline Putative DNA G-quadruplex formation within the promoters of Plasmodium falciparum var genes.Molecular models for intrastrand DNA G-quadruplexes.

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P2860

Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics.

http://www.wikidata.org/entity/Q36959489

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2007 nî lūn-bûn

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Human telomere, oncogenic prom ...... rgets for cancer therapeutics.

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type

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Human telomere, oncogenic prom ...... rgets for cancer therapeutics.

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Human telomere, oncogenic prom ...... rgets for cancer therapeutics.

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Human telomere, oncogenic prom ...... rgets for cancer therapeutics.

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Anh Tuân Phan

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Dinshaw J Patel

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Vitaly Kuryavyi

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P2860

Mammalian telomeres end in a large duplex loop

Normal human chromosomes have long G-rich telomeric overhangs at one end

Quadruplex DNA: sequence, topology and structure

Crystal structure of parallel quadruplexes from human telomeric DNA

The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases

Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro.

Highly prevalent putative quadruplex sequence motifs in human DNA

Prevalence of quadruplexes in the human genome.

Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription

Genome-wide prediction of G4 DNA as regulatory motifs: role in Escherichia coli global regulation

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