Kinetic role for mammalian SF1/BBP in spliceosome assembly and function after polypyrimidine tract recognition by U2AF.
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Human splicing factor SF3a, but not SF1, is essential for pre-mRNA splicing in vivoMammalian splicing factor SF1 interacts with SURP domains of U2 snRNP-associated proteinsU2 small nuclear ribonucleoprotein particle (snRNP) auxiliary factor of 65 kDa, U2AF65, can promote U1 snRNP recruitment to 5' splice sitesThe conserved RNA recognition motif 3 of U2 snRNA auxiliary factor (U2AF 65) is essential in vivo but dispensable for activity in vitroThe transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1Unusual intron conservation near tissue-regulated exons found by splicing microarrays.The Caenorhabditis elegans gene mfap-1 encodes a nuclear protein that affects alternative splicingMutations in the Caenorhabditis elegans U2AF large subunit UAF-1 alter the choice of a 3' splice site in vivoStructure, phosphorylation and U2AF65 binding of the N-terminal domain of splicing factor 1 during 3'-splice site recognitionJMJD6 and U2AF65 co-regulate alternative splicing in both JMJD6 enzymatic activity dependent and independent manner.Recognition of RNA branch point sequences by the KH domain of splicing factor 1 (mammalian branch point binding protein) in a splicing factor complex.Competition between a noncoding exon and introns: Gomafu contains tandem UACUAAC repeats and associates with splicing factor-1.The protein kinase KIS impacts gene expression during development and fear conditioning in adult mice.Analysis of in situ pre-mRNA targets of human splicing factor SF1 reveals a function in alternative splicingHuman transcription elongation factor CA150 localizes to splicing factor-rich nuclear speckles and assembles transcription and splicing components into complexes through its amino and carboxyl regions.An SF1 affinity model to identify branch point sequences in human introns.Purification, crystallization and preliminary X-ray crystallographic analysis of a central domain of human splicing factor 1.In vivo effects on intron retention and exon skipping by the U2AF large subunit and SF1/BBP in the nematode Caenorhabditis elegans.Major phosphorylation of SF1 on adjacent Ser-Pro motifs enhances interaction with U2AF65.A conditional role of U2AF in splicing of introns with unconventional polypyrimidine tractsIntronic features that determine the selection of the 3' splice site.Probing interactions between the U2 small nuclear ribonucleoprotein and the DEAD-box protein, Prp5.SF1 Phosphorylation Enhances Specific Binding to U2AF65 and Reduces Binding to 3'-Splice-Site RNA.Dual function for U2AF(35) in AG-dependent pre-mRNA splicing.Pre-spliceosome formation in S.pombe requires a stable complex of SF1-U2AF(59)-U2AF(23)Efficient transcription through an intron requires the binding of an Sm-type U1 snRNP with intact stem loop II to the splice donorGenomic mRNA profiling reveals compensatory mechanisms for the requirement of the essential splicing factor U2AF.Universal correction of enzymatic sequence bias reveals molecular signatures of protein/DNA interactions.
P2860
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P2860
Kinetic role for mammalian SF1/BBP in spliceosome assembly and function after polypyrimidine tract recognition by U2AF.
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2000 nî lūn-bûn
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2000 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
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2000 թվականի դեկտեմբերին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年论文
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name
Kinetic role for mammalian SF1 ...... ine tract recognition by U2AF.
@ast
Kinetic role for mammalian SF1 ...... ine tract recognition by U2AF.
@en
type
label
Kinetic role for mammalian SF1 ...... ine tract recognition by U2AF.
@ast
Kinetic role for mammalian SF1 ...... ine tract recognition by U2AF.
@en
prefLabel
Kinetic role for mammalian SF1 ...... ine tract recognition by U2AF.
@ast
Kinetic role for mammalian SF1 ...... ine tract recognition by U2AF.
@en
P2860
P356
P1476
Kinetic role for mammalian SF1 ...... ine tract recognition by U2AF.
@en
P2093
P2860
P304
38059-38066
P356
10.1074/JBC.M001483200
P407
P577
2000-12-01T00:00:00Z