Dual function for U2AF(35) in AG-dependent pre-mRNA splicing.
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Control of pre-mRNA splicing by the general splicing factors PUF60 and U2AF(65)U2 small nuclear ribonucleoprotein particle (snRNP) auxiliary factor of 65 kDa, U2AF65, can promote U1 snRNP recruitment to 5' splice sitesThe conserved RNA recognition motif 3 of U2 snRNA auxiliary factor (U2AF 65) is essential in vivo but dispensable for activity in vitroBiased exon/intron distribution of cryptic and de novo 3' splice sitesMulti-domain conformational selection underlies pre-mRNA splicing regulation by U2AFAuxiliary splice factor U2AF26 and transcription factor Gfi1 cooperate directly in regulating CD45 alternative splicingDeletion of the N-terminus of SF2/ASF permits RS-domain-independent pre-mRNA splicing.Exonic splicing enhancers in fission yeast: functional conservation demonstrates an early evolutionary origin.Analysis of mutant phenotypes and splicing defects demonstrates functional collaboration between the large and small subunits of the essential splicing factor U2AF in vivo.Allele-specific recognition of the 3' splice site of INS intron 1Structure-guided U2AF65 variant improves recognition and splicing of a defective pre-mRNA.The RNAissance family: SR proteins as multifaceted regulators of gene expressionBifunctional antisense oligonucleotides provide a trans-acting splicing enhancer that stimulates SMN2 gene expression in patient fibroblasts.AG-dependent 3'-splice sites are predisposed to aberrant splicing due to a mutation at the first nucleotide of an exon.RNA interference knockdown of hU2AF35 impairs cell cycle progression and modulates alternative splicing of Cdc25 transcripts.Kaposi's sarcoma-associated herpesvirus ORF57 functions as a viral splicing factor and promotes expression of intron-containing viral lytic genes in spliceosome-mediated RNA splicing.Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage.Mutational analysis of the U12-dependent branch site consensus sequence.Human immunodeficiency virus type 1 hnRNP A/B-dependent exonic splicing silencer ESSV antagonizes binding of U2AF65 to viral polypyrimidine tracts.U2AF modulates poly(A) length control by the poly(A)-limiting element.The splicing factor U2AF small subunit is functionally conserved between fission yeast and humans.Intronic features that determine the selection of the 3' splice site.In vivo requirement of the small subunit of U2AF for recognition of a weak 3' splice site.Identification of U2AF(35)-dependent exons by RNA-Seq reveals a link between 3' splice-site organization and activity of U2AF-related proteins.Diversity of vertebrate splicing factor U2AF35: identification of alternatively spliced U2AF1 mRNAS.Systematic study of sequence motifs for RNA trans splicing in Trypanosoma brucei.U2AF1 mutations alter splice site recognition in hematological malignancies.Stoichiometries of U2AF35, U2AF65 and U2 snRNP reveal new early spliceosome assembly pathways.A novel 3' splice site recognition by the two zinc fingers in the U2AF small subunit.The thermodynamic patterns of eukaryotic genes suggest a mechanism for intron-exon recognition.Molecular characterization and phylogeny of U2AF35 homologs in plants.Rules and tools to predict the splicing effects of exonic and intronic mutations.
P2860
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P2860
Dual function for U2AF(35) in AG-dependent pre-mRNA splicing.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
2001年论文
@zh
2001年论文
@zh-cn
name
Dual function for U2AF
@nl
Dual function for U2AF(35) in AG-dependent pre-mRNA splicing.
@en
type
label
Dual function for U2AF
@nl
Dual function for U2AF(35) in AG-dependent pre-mRNA splicing.
@en
prefLabel
Dual function for U2AF
@nl
Dual function for U2AF(35) in AG-dependent pre-mRNA splicing.
@en
P2093
P2860
P1476
Dual function for U2AF(35) in AG-dependent pre-mRNA splicing.
@en
P2093
P2860
P304
P356
10.1128/MCB.21.22.7673-7681.2001
P407
P577
2001-11-01T00:00:00Z