Structural insights into G-quadruplexes: towards new anticancer drugs.
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Fluorine in medicinal chemistry: β-fluorination of peripheral pyrrolidines attached to acridine ligands affects their interactions with G-quadruplex DNAc-MYC promoter G-quadruplex formed at the 5'-end of NHE III1 element: insights into biological relevance and parallel-stranded G-quadruplex stabilitySolution Structure of a 2:1 Quindoline–c-MYC G-Quadruplex: Insights into G-Quadruplex-Interactive Small Molecule Drug DesignSolution structure of the major G-quadruplex formed in the human VEGF promoter in K+: insights into loop interactions of the parallel G-quadruplexesSanguinaria canadensis: Traditional Medicine, Phytochemical Composition, Biological Activities and Current UsesDo we know whether potential G-quadruplexes actually form in long functional RNA molecules?G-quadruplexes in pathogens: a common route to virulence control?Pyrrolobenzodiazepines (PBDs) do not bind to DNA G-quadruplexesPrefolded Synthetic G-Quartets Display Enhanced Bioinspired Properties.Selective lighting up of epiberberine alkaloid fluorescence by fluorophore-switching aptamer and stoichiometric targeting of human telomeric DNA G-quadruplex multimer.Two cationic porphyrin isomers showing different multimeric G-quadruplex recognition specificity against monomeric G-quadruplexesTargeting G-quadruplexes in gene promoters: a novel anticancer strategy?Thermodynamic stability and folding kinetics of the major G-quadruplex and its loop isomers formed in the nuclease hypersensitive element in the human c-Myc promoter: effect of loops and flanking segments on the stability of parallel-stranded intramBinding of gemini bisbenzimidazole drugs with human telomeric G-quadruplex dimers: effect of the spacer in the design of potent telomerase inhibitorsGaining insights into the small molecule targeting of the G-quadruplex in the c-MYC promoter using NMR and an allele-specific transcriptional assay.Advances in the molecular design of potential anticancer agents via targeting of human telomeric DNA.Aromatic core extension in the series of N-cyclic bay-substituted perylene G-quadruplex ligands: increased telomere damage, antitumor activity, and strong selectivity for neoplastic over healthy cells.G-quadruplexes in viruses: function and potential therapeutic applications.Single-molecule analysis of thymine dimer-containing G-quadruplexes formed from the human telomere sequence.A Discovery Funnel for Nucleic Acid Binding Drug CandidatesIdentification of new natural DNA G-quadruplex binders selected by a structure-based virtual screening approach.Linkage of cation binding and folding in human telomeric quadruplex DNA.Molecular docking and dynamics simulations on the interaction of cationic porphyrin-anthraquinone hybrids with DNA G-quadruplexes.Development of fluorescent probes specific for parallel-stranded G-quadruplexes by a library approach.The interaction of telomeric DNA and C-myc22 G-quadruplex with 11 natural alkaloids.G-quadruplex structure and stability illuminated by 2-aminopurine phasor plotsHit Identification of a Novel Dual Binder for h-telo/c-myc G-Quadruplex by a Combination of Pharmacophore Structure-Based Virtual Screening and Docking Refinement.Separation of Quadruplex Polymorphism in DNA Sequences by Reversed-Phase Chromatography.Isothermal folding of G-quadruplexes.The major G-quadruplex formed in the human platelet-derived growth factor receptor β promoter adopts a novel broken-strand structure in K+ solution.Sequence, stability, and structure of G-quadruplexes and their interactions with drugsSite specific replacements of a single loop nucleoside with a dibenzyl linker may switch the activity of TBA from anticoagulant to antiproliferative.A cis-element with mixed G-quadruplex structure of NPGPx promoter is essential for nucleolin-mediated transactivation on non-targeting siRNA stress.G-quadruplex structures and G-quadruplex-interactive compounds.Specific recognition and stabilization of monomeric and multimeric G-quadruplexes by cationic porphyrin TMPipEOPP under molecular crowding conditionsDNA G-quadruplex and its potential as anticancer drug targetInteractions of the human telomere sequence with the nanocavity of the α-hemolysin ion channel reveal structure-dependent electrical signatures for hybrid folds.Telomere targeting with a novel G-quadruplex-interactive ligand BRACO-19 induces T-loop disassembly and telomerase displacement in human glioblastoma cells.Polyethylene glycol binding alters human telomere G-quadruplex structure by conformational selection.Discovery of a structural-element specific G-quadruplex "light-up" probe.
P2860
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P2860
Structural insights into G-quadruplexes: towards new anticancer drugs.
description
2010 nî lūn-bûn
@nan
2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Structural insights into G-quadruplexes: towards new anticancer drugs.
@ast
Structural insights into G-quadruplexes: towards new anticancer drugs.
@en
type
label
Structural insights into G-quadruplexes: towards new anticancer drugs.
@ast
Structural insights into G-quadruplexes: towards new anticancer drugs.
@en
prefLabel
Structural insights into G-quadruplexes: towards new anticancer drugs.
@ast
Structural insights into G-quadruplexes: towards new anticancer drugs.
@en
P2860
P356
P1476
Structural insights into G-quadruplexes: towards new anticancer drugs.
@en
P2093
Danzhou Yang
Keika Okamoto
P2860
P304
P356
10.4155/FMC.09.172
P577
2010-04-01T00:00:00Z