Mda-7, a novel melanoma differentiation associated gene with promise for cancer gene therapy.
about
Cloning of a new type II cytokine receptor activating signal transducer and activator of transcription (STAT)1, STAT2 and STAT3Interleukin-24 and its receptorsA novel splicing variant of mouse interleukin (IL)-24 antagonizes IL-24-induced apoptosisIdentification and cloning of human polynucleotide phosphorylase, hPNPase old-35, in the context of terminal differentiation and cellular senescence.Targeted therapies for killing tumor cells.Dual cancer-specific targeting strategy cures primary and distant breast carcinomas in nude mice.mda-7 (IL-24) Mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK.Tumour suppressor function of MDA-7/IL-24 in human breast cancerEnhanced apoptosis-inducing function of MDA-7/IL-24 RGD mutant via the increased adhesion to tumor cells.mda-7/IL-24: multifunctional cancer-specific apoptosis-inducing cytokineMDA-7/IL-24: multifunctional cancer killing cytokineIL-24: a classic cytokine and/or a potential cure for cancer?IL-24 modulates IFN-gamma expression in patients with tuberculosis.Suppression effect of recombinant adenovirus vector containing hIL-24 on Hep-2 laryngeal carcinoma cells.Killing of human melanoma cells induced by activation of class I interferon-regulated signaling pathways via MDA-7/IL-24.Combinatorial synergy induced by adenoviral-mediated mda-7 and Herceptin in Her-2+ breast cancer cells.Unique aspects of mda-7/IL-24 antitumor bystander activity: establishing a role for secretion of MDA-7/IL-24 protein by normal cells.Induction of reactive oxygen species renders mutant and wild-type K-ras pancreatic carcinoma cells susceptible to Ad.mda-7-induced apoptosis.Mechanistic aspects of mda-7/IL-24 cancer cell selectivity analysed via a bacterial fusion protein.Bcl-2 and Bcl-x(L) differentially protect human prostate cancer cells from induction of apoptosis by melanoma differentiation associated gene-7, mda-7/IL-24.The cancer growth suppressing gene mda-7 induces apoptosis selectively in human melanoma cells.Melanoma differentiation associated gene-7, mda-7/IL-24, selectively induces growth suppression, apoptosis and radiosensitization in malignant gliomas in a p53-independent manner.Genomic structure, chromosomal localization and expression profile of a novel melanoma differentiation associated (mda-7) gene with cancer specific growth suppressing and apoptosis inducing properties.
P2860
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P2860
Mda-7, a novel melanoma differentiation associated gene with promise for cancer gene therapy.
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2000 nî lūn-bûn
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2000 թուականի Յունուարին հրատարակուած գիտական յօդուած
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2000 թվականի հունվարին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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name
Mda-7, a novel melanoma differ ...... omise for cancer gene therapy.
@ast
Mda-7, a novel melanoma differ ...... omise for cancer gene therapy.
@en
type
label
Mda-7, a novel melanoma differ ...... omise for cancer gene therapy.
@ast
Mda-7, a novel melanoma differ ...... omise for cancer gene therapy.
@en
prefLabel
Mda-7, a novel melanoma differ ...... omise for cancer gene therapy.
@ast
Mda-7, a novel melanoma differ ...... omise for cancer gene therapy.
@en
P2093
P356
P1476
Mda-7, a novel melanoma differ ...... omise for cancer gene therapy.
@en
P2093
M T Madireddi
N I Goldstein
P B Fisher
P304
P356
10.1007/0-306-46817-4_22
P407
P577
2000-01-01T00:00:00Z