The cancer growth suppressing gene mda-7 induces apoptosis selectively in human melanoma cells.
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Down-regulation of Myc as a potential target for growth arrest induced by human polynucleotide phosphorylase (hPNPaseold-35) in human melanoma cellsA novel splicing variant of mouse interleukin (IL)-24 antagonizes IL-24-induced apoptosisIdentification and cloning of human polynucleotide phosphorylase, hPNPase old-35, in the context of terminal differentiation and cellular senescence.Recombinant interleukin-24 lacks apoptosis-inducing properties in melanoma cells.The p38 MAPK regulates IL-24 expression by stabilization of the 3' UTR of IL-24 mRNA.Cisplatin enhances protein kinase R-like endoplasmic reticulum kinase- and CD95-dependent melanoma differentiation-associated gene-7/interleukin-24-induced killing in ovarian carcinoma cellsTargeting gene expression selectively in cancer cells by using the progression-elevated gene-3 promoter.MDA-7/IL-24-induced cell killing in malignant renal carcinoma cells occurs by a ceramide/CD95/PERK-dependent mechanism.Inhibition of multiple protective signaling pathways and Ad.5/3 delivery enhances mda-7/IL-24 therapy of malignant gliomaPERK-dependent regulation of ceramide synthase 6 and thioredoxin play a key role in mda-7/IL-24-induced killing of primary human glioblastoma multiforme cells.Characterization of the canine mda-7 gene, transcripts and expression patterns.Dual cancer-specific targeting strategy cures primary and distant breast carcinomas in nude mice.Adenovirus-mediated hPNPase(old-35) gene transfer as a therapeutic strategy for neuroblastomamda-7 (IL-24) Mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK.Tumour suppressor function of MDA-7/IL-24 in human breast cancerEnhanced apoptosis-inducing function of MDA-7/IL-24 RGD mutant via the increased adhesion to tumor cells.Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions.The development of MDA-7/IL-24 as a cancer therapeuticOncolytic adenovirus SG600-IL24 selectively kills hepatocellular carcinoma cell lines.Secretable chaperone Grp170 enhances therapeutic activity of a novel tumor suppressor, mda-7/IL-24Enhancing mda-7/IL-24 therapy in renal carcinoma cells by inhibiting multiple protective signaling pathways using sorafenib and by Ad.5/3 gene deliveryA serotype 5/3 adenovirus expressing MDA-7/IL-24 infects renal carcinoma cells and promotes toxicity of agents that increase ROS and ceramide levels.Insights into glutamate transport regulation in human astrocytes: cloning of the promoter for excitatory amino acid transporter 2 (EAAT2).Cloning and characterization of SARI (suppressor of AP-1, regulated by IFN).In silico identification of opossum cytokine genes suggests the complexity of the marsupial immune system rivals that of eutherian mammals.mda-7/IL-24: a unique member of the IL-10 gene family promoting cancer-targeted toxicity.Splice variants of mda-7/IL-24 differentially affect survival and induce apoptosis in U2OS cells.Enhanced delivery of mda-7/IL-24 using a serotype chimeric adenovirus (Ad.5/3) in combination with the Apogossypol derivative BI-97C1 (Sabutoclax) improves therapeutic efficacy in low CAR colorectal cancer cellsmda-7/IL-24: multifunctional cancer-specific apoptosis-inducing cytokineGene therapy strategies to improve the effectiveness of cancer radiotherapy.Radiogenic therapy: novel approaches for enhancing tumor radiosensitivity.MDA-7/IL-24: multifunctional cancer killing cytokineConstruction of expressing vectors including melanoma differentiation-associated gene-7 (mda-7) fused with the RGD sequences for better tumor targetingMDA-7/IL-24 functions as a tumor suppressor gene in vivo in transgenic mouse models of breast cancer.Melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24): novel gene therapeutic for metastatic melanoma.Melanoma differentiation associated gene-7 (mda-7)/IL-24: a 'magic bullet' for cancer therapy?Mining the epigenome for methylated genes in lung cancer.Selected approaches for rational drug design and high throughput screening to identify anti-cancer moleculesIL-24: a classic cytokine and/or a potential cure for cancer?Novel mechanism of MDA-7/IL-24 cancer-specific apoptosis through SARI induction.
P2860
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P2860
The cancer growth suppressing gene mda-7 induces apoptosis selectively in human melanoma cells.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
The cancer growth suppressing ...... ively in human melanoma cells.
@en
type
label
The cancer growth suppressing ...... ively in human melanoma cells.
@en
prefLabel
The cancer growth suppressing ...... ively in human melanoma cells.
@en
P2093
P2860
P356
P1433
P1476
The cancer growth suppressing ...... ively in human melanoma cells.
@en
P2093
Irina V Lebedeva
John C Reed
Paul B Fisher
Shinichi Kitada
Yonmee Chang
Zao-zhung Su
P2860
P2888
P304
P356
10.1038/SJ.ONC.1205116
P407
P577
2002-01-01T00:00:00Z
P5875
P6179
1016888368