Deubiquitinating function of ataxin-3: insights from the solution structure of the Josephin domain. - Wikidata - wikimedia - TriplyDB

Deubiquitinating function of ataxin-3: insights from the solution structure of the Josephin domain.

Deubiquitinating function of ataxin-3: insights from the solution structure of the Josephin domain.

http://www.wikidata.org/entity/Q33920788

about

Regulation of retrotranslocation by p97-associated deubiquitinating enzyme ataxin-3 Crystal structure of a Josephin-ubiquitin complex: evolutionary restraints on ataxin-3 deubiquitinating activity Mdm2 directs the ubiquitination of beta-arrestin-sequestered cAMP phosphodiesterase-4D5 Ubiquitination directly enhances activity of the deubiquitinating enzyme ataxin-3 Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes Cell biology of spinocerebellar ataxia Investigation of the Josephin Domain protein-protein interaction by molecular dynamics Protein Aggregates Are Recruited to Aggresome by Histone Deacetylase 6 via Unanchored Ubiquitin C Termini Mode of substrate recognition by the Josephin domain of ataxin-3, which has an endo-type deubiquitinase activity Aggresome formation and neurodegenerative diseases: therapeutic implications Proteotoxic stress increases nuclear localization of ataxin-3 Embryonic demise caused by targeted disruption of a cysteine protease Dub-2 Aldosterone and angiotensin II induce protein aggregation in renal proximal tubules.Trinucleotide repeats: a structural perspective Alpha4 is a ubiquitin-binding protein that regulates protein serine/threonine phosphatase 2A ubiquitination Potential regulatory relationship between the nested gene DDC8 and its host gene tissue inhibitor of metalloproteinase-2 Josephin Domain Structural Conformations Explored by Metadynamics in Essential Coordinates.Ataxin-3 promotes genome integrity by stabilizing Chk1.Ataxin-3 plays a role in mouse myogenic differentiation through regulation of integrin subunit levels Structural transformation of the tandem ubiquitin-interacting motifs in ataxin-3 and their cooperative interactions with ubiquitin chains.Ataxin-3 expression correlates with the clinicopathologic features of gastric cancer A major role for side-chain polyglutamine hydrogen bonding in irreversible ataxin-3 aggregation.The complexities of p97 function in health and disease Dominant negative effect of polyglutamine expansion perturbs normal function of ataxin-3 in neuronal cells.Characterization of the conformational fluctuations in the Josephin domain of ataxin-3.Deubiquitinating enzyme specificity for ubiquitin chain topology profiled by di-ubiquitin activity probes Balancing act: deubiquitinating enzymes in the nervous system.The role of the mammalian DNA end-processing enzyme polynucleotide kinase 3'-phosphatase in spinocerebellar ataxia type 3 pathogenesis.Toward understanding Machado-Joseph disease A mutant ataxin-3 fragment results from processing at a site N-terminal to amino acid 190 in brain of Machado-Joseph disease-like transgenic mice.The Machado-Joseph Disease Deubiquitinase Ataxin-3 Regulates the Stability and Apoptotic Function of p53 Roles of p97-associated deubiquitinases in protein quality control at the endoplasmic reticulum Ataxin-3 phosphorylation decreases neuronal defects in spinocerebellar ataxia type 3 models Machado-Joseph disease/spinocerebellar ataxia type 3.Characterization of ubiquitin and ubiquitin-like-protein isopeptidase activities.The 2.2-Angstrom resolution crystal structure of the carboxy-terminal region of ataxin-3.Reverse the curse--the role of deubiquitination in cell cycle control.Protein partners of deubiquitinating enzymes.Polyubiquitin binding and disassembly by deubiquitinating enzymes.Thermodynamic and kinetic stability of the Josephin Domain closed arrangement: evidences from replica exchange molecular dynamics

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Deubiquitinating function of ataxin-3: insights from the solution structure of the Josephin domain.

http://www.wikidata.org/entity/Q33920788

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2005 nî lūn-bûn

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Proceedings of the National Academy of Sciences of the United States of America

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Deubiquitinating function of a ...... ucture of the Josephin domain.

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Francesca Senic-Matuglia

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Michael E Hodsdon

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Pier Paolo Di Fiore

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Simona Polo

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Yuxin Mao

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P2860

Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B

Ataxin-3 interactions with rad23 and valosin-containing protein and its associations with ubiquitin chains and the proteasome are consistent with a role in ubiquitin-mediated proteolysis

Structural basis for the specificity of ubiquitin C-terminal hydrolases

A novel all helix fold of the AP180 amino-terminal domain for phosphoinositide binding and clathrin assembly in synaptic vesicle endocytosis

Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde

Protein NMR structure determination with automated NOE assignment using the new software CANDID and the torsion angle dynamics algorithm DYANA

Dali: a network tool for protein structure comparison

Torsion angle dynamics for NMR structure calculation with the new program DYANA

NMRPipe: a multidimensional spectral processing system based on UNIX pipes

Protein backbone angle restraints from searching a database for chemical shift and sequence homology

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102

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Pietro De Camilli

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