Disruption of TGF-beta growth inhibition by oncogenic ras is linked to p27Kip1 mislocalization.
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Rapamycin potentiates transforming growth factor beta-induced growth arrest in nontransformed, oncogene-transformed, and human cancer cells.RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility.Deregulation of p27 by oncogenic signaling and its prognostic significance in breast cancerHER-2 overexpression differentially alters transforming growth factor-beta responses in luminal versus mesenchymal human breast cancer cellsDifferent domains regulate homomeric and heteromeric complex formation among type I and type II transforming growth factor-beta receptors.A pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppressionp27: a barometer of signaling deregulation and potential predictor of response to targeted therapies.CRL2(LRR-1) targets a CDK inhibitor for cell cycle control in C. elegans and actin-based motility regulation in human cellsDiscovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotypeLow molecular weight cyclin E is associated with p27-resistant, high-grade, high-stage and invasive bladder cancer.Loss of p27Kip¹ promotes metaplasia in the pancreas via the regulation of Sox9 expressionRas as a therapeutic target in hematologic malignancies.Antibody-directed coupling of endoglin and MMP-14 is a key mechanism for endoglin shedding and deregulation of TGF-β signaling.Multiple degradation pathways regulate versatile CIP/KIP CDK inhibitors.An integrated view of cyclin E function and regulationClinical significance of cell cycle inhibitors in hepatocellular carcinoma.Non-malignant and tumor-derived cells differ in their requirement for p27Kip1 in transforming growth factor-beta-mediated G1 arrest.Coated pit-mediated endocytosis of the type I transforming growth factor-β (TGF-β) receptor depends on a di-leucine family signal and is not required for signaling.Ras and TGF[beta] cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways.Nucleocytoplasmic shuttling of Smad1 conferred by its nuclear localization and nuclear export signals.Dual effects of Ral-activated pathways on p27 localization and TGF-β signalingKRAS mutational subtype and copy number predict in vitro response of human pancreatic cancer cell lines to MEK inhibition.Pathway- and expression level-dependent effects of oncogenic N-Ras: p27(Kip1) mislocalization by the Ral-GEF pathway and Erk-mediated interference with Smad signalingExpression of S100A4 combined with reduced E-cadherin expression predicts patient outcome in malignant melanoma.Cytoplasmic p27 is oncogenic and cooperates with Ras both in vivo and in vitro.
P2860
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P2860
Disruption of TGF-beta growth inhibition by oncogenic ras is linked to p27Kip1 mislocalization.
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2000 nî lūn-bûn
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name
Disruption of TGF-beta growth ...... ed to p27Kip1 mislocalization.
@ast
Disruption of TGF-beta growth ...... ed to p27Kip1 mislocalization.
@en
type
label
Disruption of TGF-beta growth ...... ed to p27Kip1 mislocalization.
@ast
Disruption of TGF-beta growth ...... ed to p27Kip1 mislocalization.
@en
prefLabel
Disruption of TGF-beta growth ...... ed to p27Kip1 mislocalization.
@ast
Disruption of TGF-beta growth ...... ed to p27Kip1 mislocalization.
@en
P2093
P2860
P356
P1433
P1476
Disruption of TGF-beta growth ...... ed to p27Kip1 mislocalization.
@en
P2093
Weinberg RA
P2860
P2888
P304
P356
10.1038/SJ.ONC.1203991
P407
P577
2000-11-01T00:00:00Z
P5875
P6179
1014358593