about
The Rho exchange factors Vav2 and Vav3 favor skin tumor initiation and promotion by engaging extracellular signaling loopsJAK2 tyrosine kinase phosphorylates PAK1 and regulates PAK1 activity and functionsThe Hyper-IgE Syndromes: Lessons in Nature, From Bench to BedsideA novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells.Extracellular hepatitis C virus core protein activates STAT3 in human monocytes/macrophages/dendritic cells via an IL-6 autocrine pathway.Ligand-independent activation of androgen receptors by Rho GTPase signaling in prostate cancerA novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells.Clone-specific expression, transcriptional regulation, and action of interleukin-6 in human colon carcinoma cellsArecoline induces HA22T/VGH hepatoma cells to undergo anoikis - involvement of STAT3 and RhoA activationActivation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome–associated Sos1 mutation.Selective oral ROCK2 inhibitor down-regulates IL-21 and IL-17 secretion in human T cells via STAT3-dependent mechanism.CD19-dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the tight-skin mouseSTAT3 is necessary for proliferation and survival in colon cancer-initiating cells.Cadherin-11 regulates fibroblast inflammationThe R(h)oads to Stat3: Stat3 activation by the Rho GTPases.Herbal remedy magnolol suppresses IL-6-induced STAT3 activation and gene expression in endothelial cells.Roles and regulation of stat family transcription factors in human breast cancer.Targeting colon cancer stem cells using a new curcumin analogue, GO-Y030.Rac regulates cardiovascular superoxide through diverse molecular interactions: more than a binary GTP switch.Antagonism of the Stat3-Stat3 protein dimer with salicylic acid based small molecules.A small molecule, LLL12 inhibits constitutive STAT3 and IL-6-induced STAT3 signaling and exhibits potent growth suppressive activity in human multiple myeloma cells.The Interleukin-6 inflammation pathway from cholesterol to aging--role of statins, bisphosphonates and plant polyphenols in aging and age-related diseasesModulation of human enteric epithelial barrier and ion transport function by Peyer's patch lymphocytes.Targeting of Rac GTPases blocks the spread of intact human breast cancer.The curcumin analogue hydrazinocurcumin exhibits potent suppressive activity on carcinogenicity of breast cancer cells via STAT3 inhibition.Stat3 promotes metastatic progression of prostate cancer.Rac1 modulates the formation of primordial follicles by facilitating STAT3-directed Jagged1, GDF9 and BMP15 transcription in mice.STAT3 in the systemic inflammation of cancer cachexia.RAC1 activation drives pathologic interactions between the epidermis and immune cellsDepleting Rac1 in mouse rod photoreceptors protects them from photo-oxidative stress without affecting their structure or functionModulation of anti-inflammatory response in lipopolysaccharide stimulated human THP-1 cell line and mouse model at gene expression level with indigenous putative probiotic lactobacilliAZD9150, a next-generation antisense oligonucleotide inhibitor of STAT3 with early evidence of clinical activity in lymphoma and lung cancer.Beyond structure, to survival: activation of Stat3 by cadherin engagement.Wnt and Rho GTPase signaling in osteoarthritis development and intervention: implications for diagnosis and therapy.Genetic Interactions of STAT3 and Anticancer Drug Development.Pax3 down-regulation and shut-off of melanogenesis in melanoma B16/F10.9 by interleukin-6 receptor signaling.PDGF-induced human airway smooth muscle cell proliferation requires STAT3 and the small GTPase Rac1.Regulation of Fas expression by STAT3 and c-Jun is mediated by phosphatidylinositol 3-kinase-AKT signaling.Target specificity, in vivo pharmacokinetics, and efficacy of the putative STAT3 inhibitor LY5 in osteosarcoma, Ewing's sarcoma, and rhabdomyosarcoma.Aphanin, a triterpenoid from Amoora rohituka inhibits K-Ras mutant activity and STAT3 in pancreatic carcinoma cells.
P2860
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P2860
description
2001 nî lūn-bûn
@nan
2001 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Rac1 mediates STAT3 activation by autocrine IL-6
@ast
Rac1 mediates STAT3 activation by autocrine IL-6
@en
type
label
Rac1 mediates STAT3 activation by autocrine IL-6
@ast
Rac1 mediates STAT3 activation by autocrine IL-6
@en
prefLabel
Rac1 mediates STAT3 activation by autocrine IL-6
@ast
Rac1 mediates STAT3 activation by autocrine IL-6
@en
P2093
P2860
P356
P1476
Rac1 mediates STAT3 activation by autocrine IL-6
@en
P2093
P2860
P304
P356
10.1073/PNAS.161281298
P407
P577
2001-07-24T00:00:00Z